Signaling At The Cell Surface In The Circulatory And Ventilatory Systems (biomathematical And Biomechanical Modeling Of The Circulatory And Ventilatory Systems, Vol. 3)

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems. Reviews signaling pathways in the regulation of circulatory and respiratory function Describes ion and molecular carriers and receptors Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows Front Matter....Pages i-xv Introduction....Pages 1-9 Signal Transduction....Pages 11-88 Ion Carriers....Pages 89-156 Main Sets of Ion Channels and Pumps....Pages 157-271 Transmembrane Compound Carriers....Pages 273-333 Receptors of Cell–Matrix Mass Transfer....Pages 335-359 Receptors....Pages 361-424 G-Protein-Coupled Receptors....Pages 425-591 Receptor Protein Kinases....Pages 593-687 Receptor Tyrosine Phosphatases....Pages 689-703 Morphogen Receptors....Pages 705-755 Receptors of the Immune System....Pages 757-808 Back Matter....Pages 809-982