Signal Transduction In Photoreceptor Cells: Proceedings Of An International Workshop Held At The Research Centre Jülich, Jülich, Fed. Rep. Of Germany, 8-11 August 1990 (research Reports In Physics)

This book deals with the mechanism of signal transduction in vertebrate and invertebrate photoreceptors. It contains contributions on the structure and function of rhodopsin or other G-coupled receptors, on the regulation of second messengers by enzyme cascade, the role of Ca2+ in light adaptation, control of ionic channels in photoreceptor cells. Some key points: Rhodopsin - structure and function; transducin and phosphodiesterase; arrestin and kinase; cGMP-gated channel; role of Ca2+ in photoreceptors; transduction in invertebrates; eyes of halobacteria. Front Matter....Pages II-XI Hermann Kühn — In Memoriam....Pages 1-10 Front Matter....Pages 11-11 The Eyes of Halobacteria....Pages 13-18 Front Matter....Pages 19-19 Mutagenesis Studies of Rhodopsin Phototransduction....Pages 21-30 Structural Stability of Rhodopsin and Opsin Studied by Differential Scanning Calorimetry....Pages 31-41 Molecular Analysis of Photoreceptor Protein Function....Pages 42-59 Octopus Rhodopsin....Pages 60-67 Front Matter....Pages 69-69 The Activation of Transducin: Studies on its Mechanism and Modulation....Pages 71-102 The Transitory Complexes Between Photoexcited Rhodopsin and Transducin. Biochemical and Spectroscopic Studies....Pages 103-118 The Rate of GTP Hydrolysis by Transducin and the Termination of the cGMP Cascade in Retinal Rods....Pages 119-131 The Molecular Biology of the Rod Photoreceptor cGMP Phosphodiesterase α- and β-Subunits....Pages 132-146 Front Matter....Pages 149-149 The Phosphorylation of Rhodopsin....Pages 151-159 Mechanisms of β-Adrenergic Receptor Desensitization....Pages 160-171 Front Matter....Pages 173-173 Gating Kinetics of the cGMP-Activated Conductance of Retinal Cones....Pages 175-179 Molecular Properties of the cGMP-gated Cation Channel of Rod Photoreceptor Cells as Probed with Monoclonal Antibodies....Pages 180-194 Cyclic Nucleotide-gated Channels — A Family of Proteins Involved in Vertebrate Photoreception and Olfaction....Pages 195-213 Front Matter....Pages 215-215 Interactions Between Calcium and cGMP in Dialyzed Detached Retinal Rod Outer Segments....Pages 217-235 The Role of Cytoplasmic Calcium Concentration in Photoreceptor Light Adaptation....Pages 236-258 Photoreceptor Guanylate Cyclase and Its Regulation by Calcium....Pages 259-267 Cyclic-GMP Phosphodiesterase in Photoreceptor Cells in Limulus Ventral Eye....Pages 271-280 The Molecular Mechanism of Retinal Degeneration in the Retinal Degeneration B (rdgB) Mutant of Drosophila ....Pages 281-298 Glycosylation of Dipteran Opsins During Membrane Biogenesis....Pages 299-307 Molecular Genetics of Visual Transduction in Drosophila ....Pages 308-314 Back Matter....Pages 315-322