Signal Transducers and Activators of Transcription (STATs) : Activation and Biology

The year 2003 marks the tenth anniversary of the first use of the acronym "Stat" (also written "STAT") in the scientific literature for a family of transcription factors which rapidly transduce cytokine-and growth factor­ elicited signals from the plasma membrane to the cell nucleus thereby activating gene transcription (thus, . s. ignal Transducers and Activators of Transcription). From those beginnings, the field of STAT transcription factors, their related regulatory molecules and their biology has grown exponentially in many different directions. In recognition of the rapid growth and broad scope of the STAT transcription factor field today, and to celebrate the tenth anniversary of the use of this term in the scientific literature, Kluwer Academic Publishers B. V. requested us to compile a volume on STAT transcription factors that could serve as an overview of this burgeoning area. Thus, we wanted a volume that would serve as a reference for what is known about STAT proteins and their biology, would describe the current state of ongoing research in this broad area, and would look toward the future to try to predict the discoveries that lie ahead. Our charge was to seek out the very best experts in the field and to coax them to briefly summarize their areas of expertise. Front Matter....Pages i-xxiv Introduction: A Brief History of the STATs and a Glance at the Future....Pages 1-8 Front Matter....Pages 9-9 The STAT Protein Family....Pages 11-26 The Janus Kinase Protein Family....Pages 27-42 Structural Bases of Receptor-JAK-STAT Interactions....Pages 43-53 SOCS Proteins....Pages 55-73 The PIAS Protein Family and TC-PTP....Pages 75-85 Prime Time for the Drosophila JAK/STAT Pathway....Pages 87-104 The STAT Proteins of Dictyostelium ....Pages 105-121 JAK/STATS in Zebrafish....Pages 123-134 Front Matter....Pages 135-135 IFNS and STATs, an Incestuous Relationship....Pages 137-154 Mechanisms and Biological Roles of STAT Activation by the IL-6 Family of Cytokines....Pages 155-175 Growth Hormone Induced Activation and Regulation of JAK2 and STAT Proteins....Pages 177-190 G Protein-Coupled-Receptor Mediated STAT Activation....Pages 191-206 Regulation of STATs by Posttranslational Modifications....Pages 207-222 Interactions of STATs with Src Family Kinases....Pages 223-236 The Role of Phosphatases and Reactive Oxygen Species in Regulation of the JAK/STAT Pathway....Pages 237-245 Raft-STAT Signaling and Transcytoplasmic Trafficking....Pages 247-267 Nuclear Trafficking of STAT Proteins....Pages 269-283 Interaction of STAT Signals with Other Signaling Pathways....Pages 285-298 Forward Genetics in Mammalian Cells....Pages 299-309 Front Matter....Pages 135-135 X-Ray Crystal Structure of STAT Proteins and Structure-Activity Relationships....Pages 311-325 STAT Transcriptional Activation Mechanisms....Pages 327-341 STAT-Dependent Gene Expression without Tyrosine Phosphorylation....Pages 343-351 Front Matter....Pages 353-353 JAK/STAT Signaling: A Tale of Jeeps and Trains....Pages 355-365 Viruses and STAT Proteins....Pages 367-379 STATs in Immune Responses to Viral Infections....Pages 381-397 IFNγ Receptor-STAT1 Signaling and Cancer Immunoediting....Pages 399-418 STAT Activation in T H 1/T H 2 Differentiation....Pages 419-434 Mechanisms and Biological Consequences of STAT Signaling by Cytokines that Share the Common Cytokine Receptor γ Chain, γ c ....Pages 435-463 STAT Activation in the Acute Phase Response....Pages 465-491 STAT3 Function In Vivo ....Pages 493-512 Tissue-Specific Function of STAT3....Pages 513-523 Role of STATs in the Biological Functions of Growth Hormone....Pages 525-544 STAT/SOCS Family Members in Inflammation and Diseases....Pages 545-558 Signal Transducers and Activators of Transcription in Cytokine Signaling....Pages 559-573 STAT Signaling by Erythropoietin....Pages 575-593 STATs in Cell Mobility and Polarity during Morphogenetic Movement....Pages 595-607 Negative Regulators of STAT Function in Drosophila....Pages 609-621 Jak3 and the Pathogenesis of Severe Combined Immunodeficiency....Pages 623-636 Constitutively Active STATs and Cellular Transformation....Pages 637-644 Front Matter....Pages 353-353 STAT Proteins as Molecular Targets for Cancer Therapy....Pages 645-661 STATs in the Central Nervous System....Pages 663-685 STATs in the Cardiovascular System....Pages 687-695 JAKs and STATs as Biomarkers of Disease....Pages 697-720 Drug Discovery Approaches Targeting the JAK/STAT Pathway....Pages 721-742 Erratum....Pages 747-747 Erratum to: Growth Hormone Induced Activation and Regulation of JAK2 and STAT Proteins....Pages 747-748 Erratum to: Interaction of STAT Signals with Other Signaling Pathways....Pages 748-748 Back Matter....Pages 743-746 The year 2003 marked the tenth anniversary of the first use of the acronym "Stat" (also written "STAT") in the scientific literature for a family of transcription factors which rapidly transduce cytokine and growth factor-elicited signals from the plasma membrane to the cell nucleus thereby activating gene transcription (thus, Signal Transducers and Activators of Transcription). The only fully comprehensive reference for what is known about STAT proteins and their biology, this book describes the current state of ongoing research in this broad area, and looks toward the future to try to predict the discoveries that lie ahead. With contributions from the very best experts in the field, it will prove useful to both the novice and the expert, providing a didactic overview of the STAT transcription factor field, a summary of past literature, current developments, and new uncharted, perhaps controversial, ideas and questions about STAT activation and biology