Side-effects of anti-inflammatory drugs. Part one, Clinical and epidemiological aspects : proceedings of the 2nd International Meeting on the Side-effects of Anti-inflammatory Analgesic Drugs, held at Cambridge, England, 31st July-2nd August 1985

These two volumes contain the proceedings of a 3 day international meeting held at the University of Cambidge and Queens' College Cambridge from 31st July to 2nd August 1985 on the Side-Effects of Anti-Inflammatory Analgesic Drugs. The first meeting was held in Verona, (Italy) in 1982 and the organisers felt that, with a number of recent developments including the withdrawal of a num­ ber of new anti-inflammatory drugs, and concern being expressed in the lay and specialist medical press and other media about the safety of these drugs, that it was appropriate to have a second such meeting. The meeting was attended by some 300 delegates and the dis­ cussion focussed most intently on the recent issues, e. g. the value of adverse drug reaction reporting of the non-steroidal anti­ inflammatory (NSAI) drugs, certain side-effects associated with particular NSAI drugs, the predictive value of animal models etc. Organising a meeting de novo without outside help would not have been possible without the immensely valuable help given en­ thusiastically by people and financial assistance given most generously by those pharmaceutical companies listed below. These financial contributions were given despite current economic dif­ ficulties and moves to restrict the proportion of profits towards educational activities. Front Matter....Pages i-xxv Front Matter....Pages 1-1 Introduction and historical aspects of the side-effects of anti-inflammatory analgesic drugs....Pages 3-26 Epidemiology in the United Kingdom of adverse drug reactions from non-steroidal anti-inflammatory drugs....Pages 27-35 Assessment of adverse reactions to NSAIDs: pre- and post- marketing....Pages 37-46 Incidence of serious side-effects from non-steroidal anti-inflammatory drugs (NSAIDs) in the USA....Pages 47-53 Trends and patterns in adverse drug reactions to non-steroidal anti-inflammatory drugs reported in Sweden....Pages 55-72 Rare adverse reactions to non-steroidal anti-inflammatory drugs....Pages 73-98 Pyrazoione-induced agranulocytosis: an epidemiological evaluation....Pages 99-104 Potential biases influencing interpretation of data from worldwide spontaneous ADR reports....Pages 105-110 Prescription-event monitoring of five non-steroidal anti-inflammatory drugs....Pages 111-124 Side-effects of non-steroidal anti-inflammatory drugs in children with juvenile rheumatoid arthritis....Pages 125-135 Non-steroidal anti-inflammatories: outpatient audit of patient preferences and side-effects in different diseases....Pages 137-150 Non-steroidal anti-inflammatories in the elderly....Pages 151-172 Ibuprofen overdose — the first year following over-the-counter release....Pages 173-175 Front Matter....Pages 177-177 Drug interactions between the anti-inflammatory drugs and with other agents....Pages 179-193 Interaction between non-steroidal anti-inflammatory drugs and angiotensin-converting enzyme inhibitors in man....Pages 195-201 Responders and non-responders to NSAI drug interactions — a neglected problem?....Pages 203-215 Biological implications of the metabolic chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs....Pages 217-228 A medicinal chemist’s perspective of side-effects of anti-inflammatory analgesic drugs....Pages 229-240 Genetic and environmental aspects of drug metabolism relevant to side-effects in arthritic disease....Pages 241-257 Disease-drug interactions: utility of the conditional concept for experimental pharmacology and toxicology in the context of inflammation....Pages 259-273 Front Matter....Pages 177-177 Pharmacokinetic profile of ketoprofen in elderly subjects....Pages 275-276 The effects of frusemide and Dorbanex on the pharmacokinetic profile of benoxaprofen in elderly subjects....Pages 277-279 Enantioselective disposition of a model non-steroidal anti-inflammatory drug 2-phenylpropionic acid....Pages 281-282 Front Matter....Pages 283-283 Anti-inflammatory drugs and upper gastrointestinal perforation....Pages 285-293 Piroxicam and gastrointestinal ulceration....Pages 295-302 Anti-inflammatory drugs and gastrointestinal disease....Pages 303-308 An evaluation of the frequency of anti-inflammatory and analgesic drug intake among patients with acute gastrointestinal bleeding....Pages 309-314 Back Matter....Pages 315-327 Proceedings of the 2nd International Meeting on the Side-Effects of Anti-Inflammatory Analgesic Drugs held at Cambridge, England, 31st July-2nd August, 1985