Sialoglyco Chemistry And Biology. 1. Biosynthesis, Structural Diversity, And Sialoglycopathologies Biosynthesis, Structural Diversity, And Sialoglycopathologies

The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students Front Matter....Pages i-ix Functions and Biosynthesis of O-Acetylated Sialic Acids....Pages 1-30 Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain?....Pages 31-54 Polysialic Acid in Brain Development and Synaptic Plasticity....Pages 55-96 UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis....Pages 97-137 CMP-Sialic Acid Synthetase: The Point of Constriction in the Sialylation Pathway....Pages 139-167 Natural Antibodies Against Sialoglycans....Pages 169-181 Structure and Function of Mammalian Sialidases....Pages 183-208 Back Matter....Pages 209-211 Rita Gerardy-schahn, Philippe Delannoy, Mark Von Itzstein, Editors ; With Contributions By A. Bazhenov [and 26 Others]. Includes Bibliographical References.