Shock, sepsis, and organ failure : brain damage secondary to hemorrhagic-traumatic shock, sepsis, and traumatic brain injury : Fifth Wiggers Bernard Conference 1996 [Krumbach, Austria

New findings involving the brain in traumatic and septic shock and after brain injury are reported in this book, including pathophysiological and pathohistological results. An experimental and clinical approach to treatment is presented together with specific results obtained from the encephalogram and from histopathological study with regard to the immunohistochemistry of toxic lipid peroxidant products. The latest results of clinical and experimental pathophysiology in inflammatory processes after traumatic brain injury and the therapeutic effects of hypertonic fluid therapy are also discussed.. Front Matter ....Pages I-XIII Front Matter ....Pages 1-1 Brain Damage Secondary to Hemorrhagic Traumatic Shock in Baboons (G. Schlag, K. Zarkovic, H. Redl, N. Zarkovic, G. Waeg)....Pages 3-19 Fluid Resuscitation of Brain Injury and Shock: Preventing Secondary Injury (S. R. Shackford)....Pages 20-54 Should the Hypotensive, Brain-Injured Patient Be Resuscitated with Hypertonic Solutions? (D. S. Prough, M. H. Zornow, D. S. DeWitt)....Pages 55-75 Front Matter ....Pages 77-77 Brain Dysfunction Secondary to Sepsis (A. Oppenheim, L. A. Eidelman, C. L. Sprung)....Pages 79-93 The Encephalopathy Associated with Septic Illness: Clinical Neurological Features (G. B. Young)....Pages 94-106 The Investigation of Respiratory Insufficiency in Nervous System Trauma and Sepsis (C. F. Bolton)....Pages 107-127 Changes in Cerebral Blood Flow After Endotoxin in Humans and Sheep (V. Pollard, B. Conroy, D. S. Prough, D. J. Deyo, L. Traber, D. Traber)....Pages 128-145 Histological Aspects of Sepsis-Induced Brain Changes in a Baboon Model (K. Zarkovic, N. Zarkovic, G. Schlag, H. Redl, G. Waeg)....Pages 146-164 Front Matter ....Pages 167-167 Mechanisms of Secondary Brain Damage in Severe Head Injury: A Clinical Perspective (A. Baethmann, N. Plesnila, J. Eriskat, M. Stoffel)....Pages 169-184 The Processes Involved in Traumatic Axonal Injury (T. A. Gennarelli, D. I. Graham, L. E. Thibault)....Pages 185-196 Inflammatory Process in the Pathobiology of Secondary Damage After Traumatic Brain Injury (P. M. Kochanek, S. T. DeKosky, T. Carlos, R. S. B. Clark, M. Whalen)....Pages 197-213 Experimental Cerebral Effects of Intravenous Fluid Therapy (M. H. Zornow)....Pages 214-228 Pathophysiology, Management and Outcome After Multiple Trauma (G. Regel, U. Lehmann, E. Rickels, T. Pohlemann, H. C. Pape, H. Tscherne)....Pages 229-262 Analysis of Immune Mediator Production Following Traumatic Brain Injury (T. Kossmann, V. H. J. Hans, P. M. Lenzlinger, E. Csuka, P. F. Stahel, O. Trentz et al.)....Pages 263-304 Enhanced Osteogenesis: Systemic Consequence of Traumatic Brain Injury (R. Wildburger, N. Zarkovic, S. Borovic, K. Zarkovic, Z. Kejla)....Pages 305-318 Back Matter ....Pages 319-324 A report on new findings involving the brain in traumatic and septic shock, and after brain injury. Adopting an experimental and clinical approach to treatment, the book presents specific results obtained from the encephalogram and from histopathological study with regard to the immunohistochemistry of toxic lipid peroxidant products. It also includes the latest results of clinical and experimental pathophysiology in inflammatory processes after traumatic brain injury and the therapeutic effects of hypertonic fluid therapy. This text presents findings involving the brain in traumatic and septic shock and after brain injury, including pathophysiological and pathohistological results. An experimental and clinical approach to treatment is presented with specific results.