Shock: Biochemical, Pharmacological, and Clinical Aspects : Proceedings of the International Symposium on Shock Held at Como, Italy, October 10–11, 1969

Few pathologie phenomena, as shock, can originate from so many causes and involve so many complex physiologie mechanisms: The complexity of the phenomenon, thus, has resulted in extensive study and raised many uncertainties. Different conditions, such as hemorrhage, trauma, burns, bacterial infection, and anaphylaxis, can cause a shock state which initiates a chain of biochemical events that tends to maintain the shock. Recent progress in bio­ chemistry, physiology, and pharmacology has tended to clarify this chain of events, and elucidate the possible trigger mechanism. Besides the hormonal and catecholamine involvement, the possible intervention of various protease and lysosomal enzyme septems and kinin release introduces new elements into the characteristic mosaic of the shock state. This International Symposium, organized at Lake Corno by the Italian Society of Clinical Pharmacology and the International Society of Biochemical Pharmacology, is another in aseries of symposia under the joint auspices of the School of Pharmacy, State University of New York at Buffalo, and the Institute of Pharma­ cology, University of Milan, Italy. The Symposium has gathered together eminent scientists from such varied disciplines as surgery and pharmacology, internal medicine and biochemistry, physiology and pathology, all focusing on the question of shock. The many researchers in these specialities had the possibility of meeting and discussing together in a multidisciplinary fashion the many theories and experiences associated with this problem. Front Matter....Pages i-xiii Front Matter....Pages 1-1 Effects of Hemorrhagic and Catecholamine Shock on Canine Forelimb Transcapillary Fluid Fluxes and Segmental Vascular Resistances....Pages 3-14 Renal Failure in Hemorrhagic Shock....Pages 15-25 A Consideration of the Role of the Reticuloendothelial System (RES) in Endotoxin Shock....Pages 27-57 Behaviour of Histidine Decarboxylase (HDC) in Various Forms of Shock....Pages 59-72 Extrinsic Versus Intrinsic, Coagulation-Fibrinolysis: In the Pathophysiology of Shock and Exsanguinating Diatheses....Pages 73-92 Complement and Shock....Pages 93-101 The Role of Splancnic Adrenergic Vasoconstriction in the Development of Irreversibility of Hemorrhagic Shock....Pages 103-116 Circulatory Function in the Early Postoperative Period After Pulmonary Surgery....Pages 117-124 Proposed Mechanisms for the Ameliorative Effects of Corticosteroids in Shock....Pages 125-132 Front Matter....Pages 133-133 Participation of the Kinin-System in Different Kinds of Shock....Pages 135-151 The Generation of Kinins in the Circulation of the Dog During Hypotension Due to Blood Loss....Pages 153-157 Pathophysiologic Mechanisms in Endotoxin Shock and its Therapeutic Approaches....Pages 159-170 Several Pharmacologic and Biochemical Aspects of Cysteamine- and Cystamine-Induced Shock....Pages 171-187 Effect of Varying Blood Sugar Level in Anaphylactic Shock....Pages 189-197 Front Matter....Pages 199-199 The Influence of Blood pH on Peripheral Vascular Tone: Possible Role of Proteases and Vaso-Active Polypeptides....Pages 201-214 The Influence of Some Enzymes and Enzyme Inhibitors in Shock....Pages 215-225 Pharmacologic Agents in Shock....Pages 227-239 The Reticulo-Endothelial System (R.E.S.) in Traumatic Shock....Pages 241-246 Front Matter....Pages 247-247 Problems of Clinical Research in Shock....Pages 249-253 The Recognition and Therapy of Patho-Physiologic Patterns in Human Shock....Pages 255-271 Front Matter....Pages 247-247 The Effect of Trasylol in Shock....Pages 273-282 Treatment of Acute Renal Failure and Chronic Renal Insufficiency with Additional Trasylol Therapy....Pages 283-291 The Treatment of Orthostatic Shock....Pages 293-302 The Treatment of Shock with Beta Adrenergic Blockade....Pages 303-306 Shock in Acute Pancreatitis....Pages 307-313 Kinins in the Pathogenesis of Cardiogenic Shock and Pain....Pages 315-322 Diagnosis and Treatment of Shock in Internal Medicine....Pages 323-327 Poly-N 5 -(2-Hydroxyethyl)-L-Glutamine A New Plasma Expander....Pages 329-338 Back Matter....Pages 339-353