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The acclaimed masterwork of dermatology --- reinvented by an all new editorial team For nearly half a century Fitzpatrick’s has been recognized worldwide as the field of dermatology’s cornerstone text. This trusted classic covers all of the essentials, from the basic science of the skin to the day-to-day clinical issues of managing common skin disorders. Backed by the expertise of more than 500 world-renowned contributors, it is the reference of choice for clinicians, students, and educators. Fitzpatrick’s skillful blending of science and clinical medicine is matched only by its scope, level of detail, and quality of presentation. The Ninth Edition continues this tradition of excellence with sweeping changes designed to make it even more relevant to today’s practice and education. The ALL-NEW Fitzpatrick’s: New editors diverse in expertise and international in location of practice have endeavored to build on the achievements of previous editions, while providing fresh insight into the content and new thinking regarding optimal structure of the book Reorganized and updated content – important general basic science concepts are extensively covered in dedicated chapters appearing at the beginning of the book, allowing subsequent clinical chapters to focus on relevant disease-specific pathophysiology, in addition to clinical features, diagnosis, clinical course, and management Unmatched visual presentation includes more than 3,000 illustrations, including more than 2,700 full-color photographs; all tables and At-a-Glance boxes are either new or completely revised An improved index to speed you to the information you require about a concept, condition, or therapy Cover......Page 1 Title Page......Page 5 Copyright Page......Page 6 Contents......Page 7 Contributors......Page 15 Preface......Page 31 Acknowledgments......Page 33 1 Fundamentals of Clinical Dermatology: Morphology and Special Clinical Considerations......Page 35 2 Pathology of Skin Lesions......Page 52 3 Epidemiology and Public Health in Dermatology......Page 74 4 Developmental Biology of the Skin......Page 83 5 Growth and Differentiation of the Epidermis......Page 96 6 Skin Glands: Sebaceous, Eccrine, and Apocrine Glands......Page 104 7 Biology of Hair Follicles......Page 123 8 Nail......Page 140 9 Cutaneous Vasculature......Page 150 10 The Immunological Structure of the Skin......Page 164 11 Cellular Components of the Cutaneous Immune System......Page 177 12 Soluble Mediators of the Cutaneous Immune System......Page 193 13 Basic Principles of Immunologic Diseases in Skin (Pathophysiology of Immunologic/Inflammatory Skin Diseases)......Page 226 14 Skin Barrier......Page 240 15 Epidermal and Dermal Adhesion......Page 266 16 Microbiome of the Skin......Page 287 17 Cutaneous Photobiology......Page 299 18 Genetics in Relation to the Skin......Page 323 19 Carcinogenesis and Skin......Page 344 20 Pigmentation and Melanocyte Biology......Page 362 21 Neurobiology of the Skin......Page 385 22 Atopic Dermatitis......Page 397 23 Nummular Eczema, Lichen Simplex Chronicus, and Prurigo Nodularis......Page 419 24 Allergic Contact Dermatitis......Page 429 25 Irritant Dermatitis......Page 448 26 Seborrheic Dermatitis......Page 462 27 Occupational Skin Diseases......Page 472 28 Psoriasis......Page 491 29 Pityriasis Rubra Pilaris......Page 532 30 Parapsoriasis and Pityriasis Lichenoides......Page 539 31 Pityriasis Rosea......Page 552 32 Lichen Planus......Page 561 33 Lichen Nitidus and Lichen Striatus......Page 588 34 Granuloma Annulare......Page 598 35 Sarcoidosis......Page 606 36 Sweet Syndrome......Page 621 37 Pyoderma Gangrenosum......Page 639 38 Subcorneal Pustular Dermatosis (Sneddon-Wilkinson Disease)......Page 651 39 Autoinflammatory Disorders......Page 655 40 Eosinophilic Diseases......Page 683 41 Urticaria and Angioedema......Page 718 42 Mastocytosis......Page 744 43 Erythema Multiforme......Page 757 44 Epidermal Necrolysis (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis)......Page 767 45 Cutaneous Reactions to Drugs......Page 783 46 Erythema Annulare Centrifugum and Other Figurate Erythemas......Page 799 47 The Ichthyoses......Page 809 48 Inherited Palmoplantar Keratodermas......Page 850 49 Keratosis Pilaris and Other Follicular Keratotic Disorders......Page 901 50 Acantholytic Disorders of the Skin......Page 911 51 Porokeratosis......Page 935 52 Pemphigus......Page 943 53 Paraneoplastic Pemphigus......Page 968 54 Bullous Pemphigoid......Page 978 55 Mucous Membrane Pemphigoid......Page 994 56 Epidermolysis Bullosa Acquisita......Page 1005 57 Intercellular Immunoglobulin (Ig) A Dermatosis (IgA Pemphigus)......Page 1015 58 Linear Immunoglobulin A Dermatosis and Chronic Bullous Disease of Childhood......Page 1026 59 Dermatitis Herpetiformis......Page 1036 60 Inherited Epidermolysis Bullosa......Page 1045 61 Lupus Erythematosus......Page 1071 62 Dermatomyositis......Page 1095 63 Systemic Sclerosis......Page 1120 64 Morphea and Lichen Sclerosus......Page 1140 65 Psoriatic Arthritis and Reactive Arthritis......Page 1161 66 Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, Adult-Onset Still Disease, and Rheumatic Fever......Page 1180 67 Scleredema and Scleromyxedema......Page 1197 68 Sjögren Syndrome......Page 1204 69 Relapsing Polychondritis......Page 1220 70 Anetoderma and Other Atrophic Disorders of the Skin......Page 1227 71 Acquired Perforating Disorders......Page 1237 72 Genetic Disorders Affecting Dermal Connective Tissue......Page 1246 73 Panniculitis......Page 1285 74 Lipodystrophy......Page 1329 75 Albinism and Other Genetic Disorders of Pigmentation......Page 1343 76 Vitiligo......Page 1364 77 Hypermelanoses......Page 1385 78 Acne Vulgaris......Page 1425 79 Rosacea......Page 1453 80 Acne Variants and Acneiform Eruptions......Page 1482 81 Hyperhidrosis and Anhidrosis......Page 1493 82 Bromhidrosis and Chromhidrosis......Page 1503 83 Fox-Fordyce Disease......Page 1509 84 Hidradenitis Suppurativa......Page 1514 85 Androgenetic Alopecia......Page 1529 86 Telogen Effluvium......Page 1541 87 Alopecia Areata......Page 1551 88 Cicatricial Alopecias......Page 1558 89 Hair Shaft Disorders......Page 1571 90 Hirsutism and Hypertrichosis......Page 1589 91 Nail Disorders......Page 1602 92 Polymorphic Light Eruption......Page 1645 93 Actinic Prurigo......Page 1662 94 Hydroa Vacciniforme......Page 1668 95 Actinic Dermatitis......Page 1673 96 Solar Urticaria......Page 1684 97 Phototoxicity and Photoallergy......Page 1691 98 Cold Injuries......Page 1700 99 Burns......Page 1713 100 Delusional, Obsessive-Compulsive, and Factitious Skin Diseases......Page 1727 101 Drug Abuse......Page 1739 102 Physical Abuse......Page 1751 103 Neonatal Dermatology......Page 1761 104 Pediatric and Adolescent Dermatology......Page 1784 105 Skin Changes and Diseases in Pregnancy......Page 1799 106 Skin Aging......Page 1813 107 Caring for LGBT Persons in Dermatology......Page 1826 108 Benign Epithelial Tumors, Hamartomas, and Hyperplasias......Page 1833 109 Appendage Tumors of the Skin......Page 1854 110 Epithelial Precancerous Lesions......Page 1891 111 Basal Cell Carcinoma and Basal Cell Nevus Syndrome......Page 1918 112 Squamous Cell Carcinoma and Keratoacanthoma......Page 1935 113 Merkel Cell Carcinoma......Page 1954 114 Paget’s Disease......Page 1968 115 Melanocytic Nevi......Page 1978 116 Melanoma......Page 2016 117 Histiocytosis......Page 2052 118 Vascular Tumors......Page 2076 119 Cutaneous Lymphoma......Page 2106 120 Cutaneous Pseudolymphoma......Page 2142 121 Neoplasias and Hyperplasias of Muscular and Neural Origin......Page 2164 122 Lipogenic Neoplasms......Page 2206 123 Cutaneous Changes in Nutritional Disease......Page 2233 124 The Porphyrias......Page 2268 125 Amyloidosis......Page 2292 126 Xanthomas and Lipoprotein Disorders......Page 2307 127 Fabry Disease......Page 2326 128 Calcium and Other Mineral Deposition Disorders......Page 2341 129 Graft-Versus-Host Disease......Page 2354 130 Hereditary Disorders of Genome Instability and DNA Repair......Page 2376 131 Ectodermal Dysplasias......Page 2406 132 Genetic Immunodeficiency Diseases......Page 2428 133 Skin Manifestations of Internal Organ Disorders......Page 2459 134 Cutaneous Paraneoplastic Syndromes......Page 2475 135 The Neurofibromatoses......Page 2499 136 Tuberous Sclerosis Complex......Page 2514 137 Diabetes and Other Endocrine Diseases......Page 2527 138 Cutaneous Necrotizing Venulitis......Page 2561 139 Systemic Necrotizing Arteritis......Page 2573 140 Erythema Elevatum Diutinum......Page 2596 141 Adamantiades–Behçet Disease......Page 2601 142 Kawasaki Disease......Page 2614 143 Pigmented Purpuric Dermatoses......Page 2624 144 Cryoglobulinemia and Cryofibrinogenemia......Page 2633 145 Raynaud Phenomenon......Page 2647 146 Malignant Atrophic Papulosis (Degos Disease)......Page 2664 147 Vascular Malformations......Page 2670 148 Cutaneous Changes in Arterial, Venous, and Lymphatic Dysfunction......Page 2703 149 Wound Healing......Page 2734 150 Superficial Cutaneous Infections and Pyodermas......Page 2753 151 Cellulitis and Erysipelas......Page 2780 152 Gram-Positive Infections Associated with Toxin Production......Page 2791 153 Necrotizing Fasciitis, Necrotizing Cellulitis, and Myonecrosis......Page 2804 154 Gram-Negative Coccal and Bacillary Infections......Page 2816 155 The Skin in Infective Endocarditis, Sepsis, Septic Shock, and Disseminated Intravascular Coagulation......Page 2849 156 Miscellaneous Bacterial Infections with Cutaneous Manifestations......Page 2861 157 Tuberculosis and Infections with Atypical Mycobacteria......Page 2892 158 Actinomycosis, Nocardiosis, and Actinomycetoma......Page 2910 159 Leprosy......Page 2926 160 Superficial Fungal Infection......Page 2959 161 Yeast Infections......Page 2986 162 Deep Fungal Infections......Page 2999 163 Exanthematous Viral Diseases......Page 3023 164 Herpes Simplex......Page 3055 165 Varicella and Herpes Zoster......Page 3069 166 Poxvirus Infections......Page 3099 167 Human Papillomavirus Infections......Page 3129 168 Cutaneous Manifestations of HIV and Human T-Lymphotropic Virus......Page 3141 169 Mosquito-Borne Viral Diseases......Page 3169 170 Syphilis......Page 3179 171 Endemic (Nonvenereal) Treponematoses......Page 3207 172 Chancroid......Page 3220 173 Lymphogranuloma Venereum......Page 3227 174 Granuloma Inguinale......Page 3236 175 Gonorrhea, Mycoplasma, and Vaginosis......Page 3241 176 Leishmaniasis and Other Protozoan Infections......Page 3257 177 Helminthic Infections......Page 3285 178 Scabies, Other Mites, and Pediculosis......Page 3308 179 Lyme Borreliosis......Page 3321 180 The Rickettsioses, Ehrlichioses, and Anaplasmoses......Page 3340 181 Arthropod Bites and Stings......Page 3358 182 Bites and Stings of Terrestrial and Aquatic Life......Page 3372 183 Principles of Topical Therapy......Page 3397 184 Glucocorticoids......Page 3416 185 Retinoids......Page 3429 186 Systemic and Topical Antibiotics......Page 3441 187 Dapsone......Page 3457 188 Antifungals......Page 3470 189 Antihistamines......Page 3485 190 Cytotoxic and Antimetabolic Agents......Page 3497 191 Antiviral Drugs......Page 3527 192 Immunosuppressive and Immunomodulatory Drugs......Page 3551 193 Immunobiologics: Targeted Therapy Against Cytokines, Cytokine Receptors, and Growth Factors in Dermatology......Page 3565 194 Molecular Targeted Therapies......Page 3592 195 Antiangiogenic Agents......Page 3624 196 Other Topical Medications......Page 3644 197 Photoprotection......Page 3657 198 Phototherapy......Page 3669 199 Photochemotherapy and Photodynamic Therapy......Page 3698 200 Radiotherapy......Page 3721 201 Cutaneous Surgical Anatomy......Page 3731 202 Perioperative Considerations in Dermatologic Surgery......Page 3740 203 Excisional Surgery and Repair, Flaps, and Grafts......Page 3760 204 Mohs Micrographic Surgery......Page 3795 205 Nail Surgery......Page 3808 206 Cryosurgery and Electrosurgery......Page 3825 207 Cosmeceuticals and Skin Care in Dermatology......Page 3837 208 Fundamentals of Laser and Light-Based Treatments......Page 3854 209 Laser Skin Resurfacing: Cosmetic and Medical Applications......Page 3868 210 Nonablative Laser and Light-Based Therapy: Cosmetic and Medical Indications......Page 3880 211 Noninvasive Body Contouring......Page 3891 212 Treatment of Varicose Veins and Telangiectatic Lower-Extremity Vessels......Page 3905 213 Chemical Peels and Dermabrasion......Page 3929 214 Liposuction Using Tumescent Local Anesthesia......Page 3940 215 Soft-Tissue Augmentation......Page 3945 216 Botulinum Toxin......Page 3955 217 Hair Transplantation......Page 3965 A......Page 3985 B......Page 3997 C......Page 4002 D......Page 4016 E......Page 4022 F......Page 4028 G......Page 4032 H......Page 4036 I......Page 4044 J......Page 4051 K......Page 4052 L......Page 4053 M......Page 4060 N......Page 4069 O......Page 4074 P......Page 4076 Q......Page 4089 R......Page 4090 S......Page 4094 T......Page 4104 U......Page 4112 V......Page 4114 W......Page 4118 Y......Page 4119 Z......Page 4120 The Gold-standard Text In Dermatology, Completely Updated For Today's Practice By An All-new Editorial Board. Encyclopedic In Scope, Yet Skillfully Edited To Make It Easy To Read And Understand, This Trusted Classic Delivers Everything Clinicians Need To Know About Skin, Skin Symptoms, And Skin Diseases. Presented In Full Color, Fitzpatrick's Covers All The Essentials, From The Basic Science Of Skin To The Day-to-day Clinical Issues Of Managing Common Skin Disorders Such As Acne, Skin Cancer, And Psoriasis. Backed By The Expertise Of More Than 500 World-renowned Contributors, And The Reference Of Choice For Clinicians, Students, And Educators, Fitzpatrick's Is Enhanced By Thousands Of Full-color Photographs And A Wealth Of Newly Enhanced Tables And Diagrams. The Ninth Edition Is Bolstered By A New Global Editorial Team; A Reorganized Table Of Contents; A More Simple, Readable, And Direct Writing Style, The Incorporation Of More Genetic, Syndromic, And Treatment Information Into Each Chapter; The Addition Of First, Second, And Third Line Treatment Options; And Improved Table Presentation. The Reorganized Table Of Contents Reflects How Disease Presents Rather Than Its Cause-- Important General Basic Science Concepts Are Extensively Covered In Dedicated Chapters Appearing In An Early Section Of The Book, Allowing Subsequent Clinical Chapters To Focus On Relevant Disease-specific Pathophysiology In Addition To Clinical Features, Diagnosis, Clinical Course, And Management-- Revision Of: Fitzpatrick's Dermatology In General Medicine. 2012. 8th Ed. Includes Bibliographical References And Index. "Generations of clinicians, skin biologists, residents, and educators have acclaimed Fitzpatrick's as the most authoritative and complete guide to dermatologic basic sciences, histopathology, diagnosis, and treatment. Edition after edition, it reflects the latest insights into skin diseases and skin biology--and their practical relevance to general internal medicine--while covering the scientific foundations of the specialty. This classic yet cutting-edge text is supported by the expert insights of more than 500 internationally respected contributors, and it covers everything dermatologists need to know about skin, dermatologic signs of underlying disease, and the management of all skin diseases, including acne, skin cancer, and psoriasis. Features: More than 3000 full-color photographs ; DVD with image bank includes downloadable figures from the text ; New illustration style makes difficult concepts easier to understand ; Therapeutic ladders with first, second, and third line therapies ; New or thoroughly revised chapters on Psoriasis; Skin disease in immunosuppressed patients; Epidermal stem cells; Hair growth disorders; Neonatal, pediatric, and adolescent dermatology; Radiotherapy; Immunobiologicals and cytokines; Lasers for rejuvenation ; Expanded medical and surgical therapeutics sections guide you through all treatment options." -- Publisher's website "The gold-standard text in dermatology, completely updated for today's practice by an all-new editorial board. Encyclopedic in scope, yet skillfully edited to make it easy to read and understand, this trusted classic delivers everything clinicians need to know about skin, skin symptoms, and skin diseases. Presented in full color, Fitzpatrick's covers all the essentials, from the basic science of skin to the day-to-day clinical issues of managing common skin disorders such as acne, skin cancer, and psoriasis. Backed by the expertise of more than 500 world-renowned contributors, and the reference of choice for clinicians, students, and educators, Fitzpatrick's is enhanced by thousands of full-color photographs and a wealth of newly enhanced tables and diagrams. The Ninth Edition is bolstered by a new global editorial team; a reorganized table of contents; a more simple, readable, and direct writing style, the incorporation of more genetic, syndromic, and treatment information into each chapter; the addition of first, second, and third line treatment options; and improved table presentation. The reorganized table of contents reflects how disease presents rather than its cause"-- Provided by publisher "Important general basic science concepts are extensively covered in dedicated chapters appearing in an early section of the book, allowing subsequent clinical chapters to focus on relevant disease-specific pathophysiology in addition to clinical features, diagnosis, clinical course, and management"-- Provided by publisher