Serotoninergic Neurons And 5-ht Receptors In The Cns (handbook Of Experimental Pharmacology)

This volume provides an up-to-date and comprehensive overview of the anatomy, physiology, and basic and applied pharmacology of CNS serotonin neurons and serotonin receptor subtypes required for understanding the role(s) of serotonin in brain function and in behavior. The book comprises 28 chapters on various aspects of CNS serotonin neurons, such as their development, plasticity and transduction mechanisms, their structural and functional components involved in synaptic transmission, their physiological properties, their role in behavior, their putative involvement in neuropsychiatric diseases, and their role as targets of drugs used in the treatment of CNS disorders. The book contains predominantly black-and-white illustrations, with some color illustrations. Front Matter....Pages II-XXX Development and Adult Plasticity of Serotoninergic Neurons and Their Target Cells....Pages 1-39 Anatomy of Central Serotoninergic Projection Systems....Pages 41-89 Physiology and Pharmacology of Brain Serotoninergic Neurons....Pages 91-116 Tryptophan Hydroxylase: Molecular Biology and Regulation....Pages 117-129 Molecular Analysis of Serotonin Packaging into Secretory Vesicles....Pages 131-152 Regulation of the Environment of the Interior of Serotonin-Storing Vesicles....Pages 153-174 Molecular Biology and Transductional Characteristics of 5-HT Receptors....Pages 175-212 5-Hydroxytryptamine Receptor Histochemistry: Comparison of Receptor mRNA Distribution and Radioligand Autoradiography in the Brain....Pages 213-237 The Main Features of Central 5-HT 1A Receptors....Pages 239-268 Functional Neuropharmacology of Compounds Acting at 5-HT 1B/D Receptors....Pages 269-291 5-HT-Moduline, an Endogenous Peptide Modulating Serotoninergic Activity via a Direct Interaction at 5-HT 1B/1D Receptors....Pages 293-306 Regulation of 5-HT Release in the CNS by Presynaptic 5-HT Autoreceptors and by 5-HT Heteroreceptors....Pages 307-350 Behavioral Consequences of 5-HT 1B Receptor Gene Deletion....Pages 351-365 Pharmacology of 5-HT 2 Receptors....Pages 367-394 Regulation of 5-HT 2A Receptor at the Molecular Level....Pages 395-407 Neuropharmacology of 5-HT 3 Receptor Ligands....Pages 409-438 5-HT 4 Receptors: An Update....Pages 439-474 Molecular Biology and Potential Functional Role of 5-HT 5 , 5-HT 6 , and 5-HT 7 Receptors....Pages 475-497 Electrophysiology of 5-HT Receptors....Pages 499-535 5-HT Receptors Involved in the Regulation of Hormone Secretion....Pages 537-562 Role of Serotoninergic Neurons and 5-HT Receptors in the Action of Hallucinogens....Pages 563-585 The Interaction of the Serotoninergic and Other Neuroregulatory Systems in Alcohol Dependence....Pages 587-612 Neuronal Pathophysiology of Migraine as a Basis for Acute Treatment with 5-HT Receptor Ligands....Pages 613-635 Modulation of Nociception by Descending Serotoninergic Projections....Pages 637-653 Molecular Biology of Monoamine Oxidase A and B: Their Role in the Degradation of Serotonin....Pages 655-670 Molecular Biology, Pharmacology, and Genetics of the Serotonin Transporter: Psychobiological and Clinical Implications....Pages 671-705 Animal Models of Integrated Serotoninergic Functions: Their Predictive Value for the Clinical Applicability of Drugs Interfering with Serotoninergic Transmission....Pages 707-725 Current Psychiatric Uses of Drugs Acting on the Serotonin System....Pages 727-750 Back Matter....Pages 751-767 Development And Adult Plasticity Of Serotoninergic Neurons And Their Target Cells -- Anatomy Of Central Serotoninergic Projection Systems -- Physiology And Pharmacology Of Brain Serotoninergic Neurons -- Tryptophan Hydroxylase: Molecular Biology And Regulation -- Molecular Analysis Of Serotonin Packaging Into Secretary Vesicles -- Regulation Of The Environment Of The Interior Of Serotonin-storing Vesicles -- Molecular Biology And Transductional Characteristics Of 5-ht Receptors -- 5-hydroxytryptamine Receptor Histochemistry: Comparison Of Receptor Mrna Distribution And Radioligand Autoradiography In The Brain -- The Main Features Of Central 5-ht1a Receptor -- Fuctional Neuropharmacology Of Compounds Acting At 5-ht1b/d Recptors -- 5-ht-moduline, An Endogenous Peptide Modulating Serotoninergic Activity Via A Direct Interaction At 5-ht1b/d Receptors -- Regulation Of 5-ht Release In The Cns By Presynaptic 5-ht Autoreceptors And By 5-ht Heteroreceptors --^ Behavioral Consequences Of 5-ht1b Receptor Gene Deletion -- Pharmacology Of 5-ht2 Receptors -- Regulation Of 5-ht2a Receptor At The Molecular Level -- Neuropharmacology Of 5-ht3 Receptor Ligands -- 5-ht4 Receptors: An Update -- Molecular Biology And Potential Functional Role Of 5-ht5,5-ht6, And 5-ht-- Receptors -- Electrophysiology Of 5-ht Receptors -- 5-ht Receptors Involved In The Regulation Of Hormone Secretion -- Role Of Serotoninergic Neurons And 5-ht Receptors In The Action Of Hallucinogens -- The Interaction Of The Serotoninergic And Other Neuroregulatory Systems In Alcohol Dependence -- Neuronal Pathophysiology Of Migraine As A Basis For Acute Treatment With 5-ht Receptor Ligands -- Modulation Of Nociception By Descending Serontoninergic Projections --molecular Biology Of Monomine Oxidase A And B: Their Role In The Degradation Of Serotonin --^ Molecular Biology, Pharmacology, And Genetics Of The Serotonin Transporter: Psychobiological And Clinical Implications -- Animal Models Of Integrated Serotoninergic Functions: Their Predictive Value For The Clinical Applicability Of Drugs Interfering With Serotoninergic Transmission -- Current Psychiatric Uses Of Drugs Acting On The Serotonin System. Editors, H.g. Baumgarten And M. Gothert ; Contributors, G.k. Aghajanian ... [et Al.]. Includes Bibliographical References And Index.