Serotonin and behavior: proceedings of a symposium on behavioral effects of changes in brain serotonin, held at Stanford University, Stanford, California, January 16-17, 1972, ed

Serotonin and Behavior contains the proceedings of the 1972 symposium on the behavioral effects of changes in brain serotonin, held at Stanford University in California. The papers explore the role of serotonin in behavior as well as the key biochemical and pharmacological issues involved in behavioral studies of severe psychiatric disorders in both humans and animals. The book is organized into eight sections comprised of 65 chapters, with topics ranging from the fundamental biochemistry and pharmacology of the enzymes synthesizing serotonin, particularly, tryptophan hydroxylase and its inhibitors, to the physiology and pharmacology of serotonin. Some papers discuss the link between the telencephalic content of serotonin and pain sensitivity. Other papers focus on the effects of altering serotonin on neurons in the central nervous system. There are chapters that explain the effects of altering serotonin on animal behavior, the relationship between serotonin and sleep, the use of high doses of probenecid to estimate central serotonin turnover in affective disorders and addicts, the behavioral and metabolic effects of L-tryptophan in unipolar depressed patients taking methadone, and amygdala unit activity as a reflection of functional changes in brain serotonergic neurons. Biochemists, pharmacologists, psychiatrists, psychologists, and anyone interested in psychopharmacology will find this book extremely useful. Content: Front Matter , Page iii Copyright , Page iv Biography , Page v CONTRIBUTORS , Pages xiii-xix PRECLINICAL PSYCHOPHARMACOLOGY RESEARCH REVIEW COMMITTEE (JANUARY 1972) , Page xxi PREFACE , Pages xxiii-xxiv , Jack Barchas, Earl Usdin WELCOMING STATEMENT , Page xxv , David A. Hamburg Session 1 - BIOCHEMISTRY AND PHARMACOLOGY: TRYPTOPHAN HYDROXYLASE AND INHIBITORS OF TRYPTOPHAN HYDROXYLASE , Page 3 , M.A. Lipton Moderator DOES THE TOTAL TURNOVER OF BRAIN 5-HT REFLECT THE FUNCTIONAL ACTIVITY OF 5-HT IN BRAIN? , Pages 5-7 , D.G. Grahame-Smith METABOLISM OF p -CHLOROPHENYLALANINE AND THE MOLECULAR ASPECTS OF ITS ACTION , Pages 9-18 , E.M. Gál ASSAYS AND PROPERTIES OF TRYPTOPHAN 5-HYDROXYLASE , Pages 19-32 , J. Renson COMPARATIVE STUDIES ON THE EFFECT OF PARA CHLOROPHENYLALANINE ON HYDROXYLATION OF TRYPTOPHAN IN PINEAL AND BRAIN OF RAT , Pages 33-47 , T. Deguchi, J. Barchas PHYSIOLOGIC AND DRUG-INDUCED REGULATION OF SEROTONIN SYNTHESIS , Pages 49-54 , W. Lovenberg, G.H. Besselaar, R.E. Bensinger, R.L. Jackson TRYPTOPHAN HYDROXYLASE INHIBITORS OTHER THAN PCPA , Pages 55-59 , E.G. McGeer SOME DRUG EFFECTS ON THE FUNCTIONS OF THE TWO MEASURABLE FORMS OF TRYPTOPHAN-5-HYDROXYLASE: INFLUENCE ON HYDROXYLATION AND UPTAKE OF SUBSTRATE , Pages 61-71 , S. Knapp, A.J. Mandell DISCUSSION - BIOCHEMISTRY AND PHARMACOLOGY: TRYPTOPHAN HYDROXYLASE AND INHIBITORS OF TRYPTOPHAN HYDROXYLASE , Pages 73-82 Session 2 - PHYSIOLOGY AND PHARMACOLOGY: LOCALIZATION, UPTAKE, AND METABOLISM OF SEROTONIN , Page 85 , S. Spector Moderator LOCALIZATION AND TRANSPORT OF SEROTONIN , Pages 87-96 , A. Dahlström, J. Häggendal, C. Atack SEROTONIN UPTAKE SYSTEMS IN BRAIN TISSUE , Pages 97-108 , S.H. Snyder, E.G. Shaskan, M.J. Kuhar THE ROLE OF SEROTONIN N-ACETYLTRANSFERASE IN THE ADRENERGIC REGULATION OF INDOLE METABOLISM IN THE PINEAL GLAND , Pages 109-119 , D.C. Klein CONTROL OF BRAIN 5-HT CONTENT BY DIETARY CARBOHYDRATES , Pages 121-128 , J.D. Fernstrom, R.J. Wurtman THE NORMAL OCCURRENCE OF TRYPTAMINE IN BRAIN AND ITS CONVERSION TO N-METHYL AND N-DIMETHYLTRYPTAMINE IN VITRO AND IN VIVO , Pages 129-135 , J.M. Saavedra, J. Axelrod THE ROLE OF BRAIN SEROTONIN IN THE PHARMACOLOGIC EFFECTS OF THE METHYL XANTHINES , Pages 137-147 , B. Berkowitz, S. Spector SUPPRESSION OF BRAIN SEROTONIN SYNTHESIS AND METABOLISM BY BENZODIAZEPINE MINOR TRANQUILIZERS , Pages 149-155 , J.A. Dominic DISCUSSION - PHYSIOLOGY AND PHARMACOLOGY: LOCALIZATION, UPTAKE, AND METABOLISM OF SEROTONIN , Pages 157-162 Session 3 - PHYSIOLOGY AND PHARMACOLOGY: DEPLETION OF SEROTONIN , Pages 165-166 , A. Weissman Moderator SEROTONIN AND CONVULSIONS , Pages 167-172 , W.O. Boggan BRAIN SEROTONIN AND THE PITUITARY-ADRENAL SYSTEM , Pages 173-177 , J. Vernikos-Danellis, P.A. Berger RELATIONSHIP BETWEEN TELENCEPHALIC CONTENT OF SEROTONIN AND PAIN SENSITIVITY , Pages 179-189 , J.A. Harvey, L.M. Yunger RECENT STUDIES ON THE MECHANISM OF ACTION OF CHLORINATED AMPHETAMINES , Pages 191-199 , E. Sanders-Bush AN APPROACH TO THE ASSAY OF SEROTONIN USING GAS-LIQUID CHROMATOGRAPHY AND MASS FRAGMENTOGRAPHY - THE PINEAL GLAND AS A MODEL SYSTEM , Pages 201-207 , J. DoAmaral EFFECTS OF 5,6-DIHYDROXYTRYPTAMINE ON BRAIN MONOAMINE NEURONS IN THE RAT , Pages 209-224 , H.G. Baumgarten, H.G. Schlossberger DISCUSSION - PHYSIOLOGY AND PHARMACOLOGY: DEPLETION OF SEROTONIN , Pages 225-229 Session 4 - NEUROPHYSIOLOGY: EFFECTS OF ALTERING SEROTONIN ON CENTRAL NERVOUS SYSTEM NEURONS , Page 233 , J.A. Harvey Moderator BEHAVIORAL PHARMACOLOGY OF p -CHLOROPHENYLALANINE (PCPA) , Pages 235-248 , A. Weissman THE PHYSIOLOGY AND PHARMACOLOGY OF SEROTONIN MEDIATED SYNAPSES , Pages 249-261 , F.E. Bloom, B.J. Hoffer, C. Nelson, Y-s. Sheu, G.R. Siggins DIRECT AND INDIRECT ACTIONS OF LSD, SEROTONIN AND RELATED COMPOUNDS ON SEROTONIN-CONTAINING NEURONS , Pages 263-266 , G.K. Aghajanian, H.J. Haigler 5-HT-CONTAINING NEURONS: UNIT ACTIVITY IN BEHAVING CATS , Pages 267-279 , D.J. McGinty, R.M. Harper, M.K. Fairbanks AMYGDALA UNIT ACTIVITY AS A REFLECTION OF FUNCTIONAL CHANGES IN BRAIN SEROTONERGIC NEURONS , Pages 281-289 , B.L. Jacobs SEROTONERGIC RECEPTORS IN THE CENTRAL NERVOUS SYSTEM , Pages 291-292 , S.G.A. Alivisatos THE ROLE OF HYPOTHALAMIC SEROTONIN IN THERMOREGULATION , Pages 293-302 , R.D. Myers DISCUSSION - NEUROPHYSIOLOGY: EFFECTS OF ALTERING SEROTONIN ON CENTRAL NERVOUS SYSTEM NEURONS , Pages 303-308 SESSION 5 - ANIMAL BEHAVIORAL STUDIES: BEHAVIORAL EFFECTS OF ALTERING SEROTONIN IN ANIMALS , Pages 311-314 , J.D. Barchas Moderator EFFECTS OF BEHAVIORAL MANIPULATIONS UPON BRAIN SEROTONIN AND DOPAMINE , Pages 315-324 , E.L. Bliss EFFECTS OF PCPA ON FIGHTING BEHAVIOR AND HABITUATION OF STARTLE RESPONSE IN RATS , Pages 325-333 , R.L. Conner, J.M. Stolk, S. Levine BIOCHEMICAL AND BEHAVIORAL CHANGES IN RATS WITH EXPERIMENTAL PHENYLKETONURIA , Pages 335-349 , A.E. Andersen, A.Z. Abramowitz, G. Guroff EFFECTS OF SEROTONIN DEPLETION ON BEHAVIOR IN MONKEYS , Pages 351-356 , J.W. Maas, D.E. Redmond Jr., R. Gauen EFFECTS OF PARA CHLOROPHENYLALANINE ON THE BEHAVIOR OF MONKEYS , Pages 357-364 , R.C. Boelkins CHANGES IN BRAIN SEROTONIN LEVEL AND MALE SEXUAL BEHAVIOR , Pages 365-370 , A. Zitrin DISCUSSION - ANIMAL BEHAVIORAL STUDIES: BEHAVIORAL EFFECTS OF ALTERING SEROTONIN IN ANIMALS , Pages 371-377 Session 6 - ANIMAL BEHAVIORAL STUDIES — SLEEP: THE RELATION OF SEROTONIN TO SLEEP , Pages 381-383 , D.X. Freedman Moderator SEROTONIN AND SLEEP IN THE CAT , Pages 385-400 , M. Jouvet THE EFFECT OF PARA CHLOROPHENYLALANINE ON SLEEP IN THE RAT: SOME IMPLICATIONS FOR THE SEROTONIN-SLEEP HYPOTHESIS , Pages 401-418 , A. Rechtschaffen, R.A. Lovell, D.X. Freedman, W.E. Whitehead, M. Aldrich THE EFFECT OF THE CHRONIC ADMINISTRATION OF PARA CHLOROPHENYLALANINE (PCPA) ON SLEEP PARAMETERS IN THE CAT , Pages 419-424 , W. Dement, S. Henriksen, J. Ferguson CAT BRAIN SEROTONIN CONTENT DURING SLEEP AND WAKEFULNESS , Pages 425-426 , A.K. Sinha MONOAMINERGIC SYSTEMS IN THE BRAIN AND THEIR ROLE IN THE SLEEP STATES , Pages 427-442 , P.J. Morgane, W.C. Stern 5-HTP AND THE SYNDROME OF INTENTION OR ACTION MYOCLONUS AS A SEQUEL TO HYPOXIC ENCEPHALOPATHY , Pages 443-444 , C. Guilleminault DISCUSSION - ANIMAL BEHAVIORAL STUDIES – SLEEP: THE RELATION OF SEROTONIN TO SLEEP , Pages 445-452 Session 7 - HUMAN BEHAVIOR: TESTS FOR SEROTONIN UTILIZATION IN HUMANS AND EFFECTS OF PRECURSOR LOADING IN VARIOUS DISORDERS , Pages 455-456 , J.W. Maas Moderator MONAMINE METABOLISM IN DEPRESSION: CLINICAL APPLICATION OF THE PROBENECID TEST , Pages 457-468 , H.M. van Praag, J. Korf THE USE OF PROBENECID IN HIGH DOSES FOR THE ESTIMATION OF CENTRAL SEROTONIN TURNOVER IN AFFECTIVE ILLNESS AND ADDICTS ON METHADONE , Pages 469-480 , F.K. Goodwin, R.M. Post PRECURSOR LOADING STRATEGIES , Pages 481-482 , B.J. Carroll CEREBROSPINAL FLUID LEVELS OF 5-HYDROXYINDOLEACETIC ACID IN PSYCHIATRIC DISORDERS: A CRITICAL ASSESSMENT , Pages 483-486 , S. Wilk 5-HYDROXYTRYPTOPHAN AND CHRONIC SCHIZOPHRENIA - A PRELIMINARY STUDY , Pages 487-497 , R.J. Wyatt, T. Vaughan, J. Kaplan, M. Galanter, R. Green ORAL 5-HYDROXYTRYPTOPHAN EFFECTS ON SLEEP , Pages 499-509 , V.P. Zarcone, E. Hoddes, H. Smythe DISCUSSION - HUMAN BEHAVIOR: TESTS FOR SEROTONIN UTILIZATION IN HUMANS AND EFFECTS OF PRECURSOR LOADING IN VARIOUS DISORDERS , Pages 511-518 SESSION 8 - HUMAN BEHAVIOR: TESTS FOR SEROTONIN UTILIZATION IN HUMANS AND EFFECTS OF PRECURSOR LOADING IN VARIOUS DISORDERS , Page 521 , D.A. Hamburg Moderator ROLE OF SEROTONIN IN AFFECTIVE DISORDERS , Pages 523-527 , A. Coppen BEHAVIORAL AND METABOLIC EFFECTS OF L-TRYPTOPHAN IN UNIPOLAR DEPRESSED PATIENTS , Pages 529-537 , D.L. Murphy, M. Baker, J. Kotin, W.E. Bunney Jr. BALANCE, PERMISSION, AND DISCRIMINATION AMONG AMINES: A THEORETICAL CONSIDERATION OF THE ACTIONS OF L-TRYPTOPHAN IN DISORDERS OF MOVEMENTS AND AFFECT , Pages 539-548 , A.J. Prange Jr., J.L. Sisk, I.C. Wilson, C.E. Morris, C.D. Hall, J.S. Carman CLINICAL STUDIES OF L-5-HYDROXYTRYPTOPHAN IN DEPRESSION , Pages 549-559 , H.K.H. Brodie, R. Sack, L. Siever DISCUSSION - HUMAN BEHAVIOR: TESTS FOR SEROTONIN UTILIZATION IN HUMANS AND EFFECTS OF PRECURSOR LOADING IN VARIOUS DISORDERS , Pages 561-564 SUMMARY OF SEROTONIN AND BEHAVIOR CONFERENCE , Pages 565-568 , M.A. Lipton REFERENCES , Pages 569-627 ABBREVIATIONS , Pages 629-631 SUBJECT INDEX , Pages 633-642