Sepsis: New Insights, New Therapies: Novartis Foundation Symposium 280

Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response. Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat it Describes numerous pharmacological approaches to therapy for early and late sepsis Includes detailed discussion of the various physiological systems implicated in sepsis Presents an international perspective, featuring contributions from experts from laboratories worldwide involved in the study of sepsis Sepsis: New Insights, New Therapies is an invaluable resource for all critical care physicians and researchers. It is also informative reading for immunologists, endocrinologists, neuroendocrinologists, physiologists, and pharmacologists.Content: Chapter 1 Chair's Introduction (pages 1–6): Mitchell P. Fink Chapter 2 Strategies to Modulate Cellular Energetic Metabolism during Sepsis (pages 7–20): Alessandro Protti and Mervyn Singer Chapter 3 Immunostimulation is a Rational Therapeutic Strategy in Sepsis (pages 21–36): Jerome Pugin Chapter 4 Blockade of Apoptosis as a Rational Therapeutic Strategy for the Treatment of Sepsis (pages 37–52): Alfred Ayala, Doreen E. Wesche?Soldato, Mario Perl, Joanne L. Lomas?Neira, Ryan Swan and Chun?Shiang Chung Chapter 5 Modulating Neutrophil Apoptosis (pages 53–72): John C. Marshall, Zeenat Malam and Songhui Jia Chapter 6 HMGB1 as a Potential Therapeutic Target (pages 73–91): Haichao Wang, Wei Li, Richard Goldstein, Kevin J. Tracey and Andrew E. Sama Chapter 7 Poly (ADP?Ribose) Polymerase Activation and Circulatory Shock (pages 92–107): Csaba Szabo Chapter 8 Choosing the Right Substrate (pages 108–127): Xavier Leverve, Cecile Batandier and Eric Fontaine Chapter 9 Inhibiting Glycogen Synthase Kinase 3? in Sepsis (pages 128–146): Laura Dugo, Marika Collin, David A. Allen, Nimesh S. A. Patel, Inge Bauer, Eero M. A. Mervaala, Marjut Louhelainen, Simon J. Foster, Muhammad M. Yaqoob and Christoph Thiemermann Chapter 10 Ethyl Pyruvate: A Novel Treatment for Sepsis (pages 147–159): Mitchell P. Fink Chapter 11 General Discussion I (pages 160–164): Chapter 12 Cytoprotective and Anti?Inflammatory Actions of Carbon Monoxide in Organ Injury and Sepsis Models (pages 165–181): Stefan W. Ryter and Augustine M. K. Choi Chapter 13 The Hypothalamic Pituitary Adrenal Axis in Sepsis (pages 182–203): Andrea Polito, Jerome Aboab and Djillali Annane Chapter 14 Modulating the Endocrine Response in Sepsis: Insulin and Blood Glucose Control (pages 204–222): Ilse Vanhorebeek, Lies Langouche and Greet Van den Berghe Chapter 15 The Neuronal Strategy for Inflammation (pages 223–237): Luis Ulloa and Ping Wang Chapter 16 Beta?Blockade in Burns (pages 238–251): C. T. Pereira, M. G. Jeschke and D. N. Herndon Chapter 17 System Interactions (pages 252–265): Mervyn Singer Chapter 18 Protecting the Permeability Pore and Mitochondrial Biogenesis (pages 266–280): C. A. Piantadosi, M. S. Carraway, D. W. Haden and H. B. Suliman **__Sepsis: New Insights, New Therapies__** brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response. * Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat it * Describes numerous pharmacological approaches to therapy for early and late sepsis * Includes detailed discussion of the various physiological systems implicated in sepsis * Presents an international perspective, featuring contributions from experts from laboratories worldwide involved in the study of sepsis **__Sepsis: New Insights, New Therapies__** is an invaluable resource for all critical care physicians and researchers. It is also informative reading for immunologists, endocrinologists, neuroendocrinologists, physiologists, and pharmacologists.Content: Chapter 1 Chair's Introduction (pages 1–6): Mitchell P. FinkChapter 2 Strategies to Modulate Cellular Energetic Metabolism during Sepsis (pages 7–20): Alessandro Protti and Mervyn SingerChapter 3 Immunostimulation is a Rational Therapeutic Strategy in Sepsis (pages 21–36): Jerome PuginChapter 4 Blockade of Apoptosis as a Rational Therapeutic Strategy for the Treatment of Sepsis (pages 37–52): Alfred Ayala, Doreen E. Wesche?Soldato, Mario Perl, Joanne L. Lomas?Neira, Ryan Swan and Chun?Shiang ChungChapter 5 Modulating Neutrophil Apoptosis (pages 53–72): John C. Marshall, Zeenat Malam and Songhui JiaChapter 6 HMGB1 as a Potential Therapeutic Target (pages 73–91): Haichao Wang, Wei Li, Richard Goldstein, Kevin J. Tracey and Andrew E. SamaChapter 7 Poly (ADP?Ribose) Polymerase Activation and Circulatory Shock (pages 92–107): Csaba SzaboChapter 8 Choosing the Right Substrate (pages 108–127): Xavier Leverve, Cecile Batandier and Eric FontaineChapter 9 Inhibiting Glycogen Synthase Kinase 3? in Sepsis (pages 128–146): Laura Dugo, Marika Collin, David A. Allen, Nimesh S. A. Patel, Inge Bauer, Eero M. A. Mervaala, Marjut Louhelainen, Simon J. Foster, Muhammad M. Yaqoob and Christoph ThiemermannChapter 10 Ethyl Pyruvate: A Novel Treatment for Sepsis (pages 147–159): Mitchell P. FinkChapter 11 General Discussion I (pages 160–164): Chapter 12 Cytoprotective and Anti?Inflammatory Actions of Carbon Monoxide in Organ Injury and Sepsis Models (pages 165–181): Stefan W. Ryter and Augustine M. K. ChoiChapter 13 The Hypothalamic Pituitary Adrenal Axis in Sepsis (pages 182–203): Andrea Polito, Jerome Aboab and Djillali AnnaneChapter 14 Modulating the Endocrine Response in Sepsis: Insulin and Blood Glucose Control (pages 204–222): Ilse Vanhorebeek, Lies Langouche and Greet Van den BergheChapter 15 The Neuronal Strategy for Inflammation (pages 223–237): Luis Ulloa and Ping WangChapter 16 Beta?Blockade in Burns (pages 238–251): C. T. Pereira, M. G. Jeschke and D. N. HerndonChapter 17 System Interactions (pages 252–265): Mervyn SingerChapter 18 Protecting the Permeability Pore and Mitochondrial Biogenesis (pages 266–280): C. A. Piantadosi, M. S. Carraway, D. W. Haden and H. B. Suliman Brings Together Contributions From An International Group Of Experts In Diverse Fields To Consider How The Various Pathways Implicated In Early And Late Sepsis Interact, With A Particular Emphasis On Novel Concepts And Potential New Therapeutic Approaches. Topics Covered Include Adaptive Immunity, Inflammation, Neuroendocrinology, Bioenergetics And Metabolism. Several Chapters In The Latter Half Of The Book Are Particularly Concerned With Treatment Strategies Involving Modulation Of The Neuroendocrine Response. Strategies To Modulate Cellular Energetic Metabolism During Sepsis / Alessandro Protti And Mervyn Singer -- Immunostimulation Is A Rational Therapeutic Strategy In Sepsis / Jérôme Pugin -- Blockade Of Apoptosis As A Rational Therapeutic Strategy For The Treatment Of Sepsis / Alfred Ayala, Doreen E. Wesche-soldato, Mario Perl, Joanne L. Lomas-neira, Ryan Swan And Chun-shiang Chung -- Modulating Neutrophil Apoptosis / John C. Marshall, Zeenat Malam And Songhui Jia -- Hmgb1 As A Potential Therapeutic Target / Haichao Wang, Wei Li, Richard Goldstein, Kevin J. Tracey And Andrew E. Sama -- Poly (adp-ribose) Polymerase Activation And Circulatory Shock / Csaba Szabó -- Choosing The Right Substrate / Xavier Leverve, Cécile Batandier And Eric Fontaine -- Inhibiting Glycogen Synthase Kinase 3[beta] In Sepsis / Laura Dugo, Marika Collin, David A. Allen, Nimesh S.a. Patel, Inge Bauer, Eero M.a. Mervaala, Marjut Louhelainen, Simon J. Foster, Muhammad M. Yaqoob And Christoph Thiemermann -- Ethyl Pyruvate, A Novel Treatment For Sepsis / Mitchell P. Fink -- Cytoprotective And Anti-inflammatory Actions Of Carbon Monoxide In Organ Injury And Sepsis Models / Stefan W. Ryter And Augustine M. K. Choi -- The Hypothalamic Pituitary Adrenal Axis In Sepsis / Andrea Polito, Jérôme Aboab And Djillali Annane -- Modulating The Endocrine Response In Sepsis : Insulin And Blood Glucose Control / Ilse Vanhorebeek, Lies Langouche And Greet Van Den Berghe -- The Neuronal Strategy For Inflammation / Luis Ulloa And Ping Wang -- Beta-blockade In Burns / C.t. Pereira, M.g. Jeschke And D.n. Herndon -- System Interactions / Mervyn Singer -- Protecting The Permeability Pore And Mitochondrial Biogenesis / C.a. Piantadosi, M.s. Carraway, D.w. Haden And H.b. Suliman. Symposium On Sepsis: New Insights, New Therapies, Held At The Novartis Foundation, London, 14-16 February 2006--contents P. Includes Bibliographical References And Index. Also Available In An Electronic Version. Mode Of Access: World Wide Web.