Semaphorins: Receptor and Intracellular Signaling Mechanisms (Advances in Experimental Medicine and Biology)

This book details our progress in understanding the receptor and intracellular signaling mechanisms utilized by a family of proteins called the semaphorins. Originally these protein were identified as "axon guidance cues" important for the formation of nerve tracts but now it is realized that semaphorins subserve several distinct functions in a multitude of organ systems. This book summarizes our knowledge and makes it available as a useful and comprehensive tool for the scientific community. It covers the entire semaphorin field from neurosciences to cardiovascular research and beyond, detailing all the latest techniques and results. The comprehensive overview of semaphorin biology and signaling presented in this book allows one to compare semaphorin functions between different biological systems. The book will be of interest to people working in the field as well as those who work in other fields of science and would like to learn more about semaphorins and associated signaling mechanisms. The Book Summarizes Our Progress In Understanding The Receptor And Intracellular Signaling Mechanisms Utilized By A Family Of Proteins Called The Semaphorins. Originally These Protein Were Identified As Axon Guidance Cues Important For The Formation Of Nerve Tracts But Now It Is Realized That Semaphorins Subserve Several Distinct Functions In A Multitude Of Organ Systems. The Purpose Of This Book Is To Summarize Our Knowledge And Make It Available As A Useful And Comprehensive Tool For The Scientific Community. This Book Will Both Be Interesting For People Working In The Field As Well As Colleagues That Work In Other Fields Of Science And Would Like To Learn More About Semaphorins And Associated Signaling Mechanisms. All The Latest Techniques And Results Are Summarized In This Book Which Covers The Entire Semaphorin Field From Neurosciences To Cardiovascular Research And Beyond. The Strength Of This Book Is That It Gives A Very Comprehensive Overview Of All Our Knowledge Of. The Crmp Family Of Proteins And Their Role In Sema3a Signaling / Eric F. Schmidt And Stephen M. Strittmatter -- Gtpases In Semaphorin Signaling / Andreas W. Püschel -- Intracellular Kinases In Semaphorin Signaling / Aminul Ahmed And Britta J. Eickholt -- Mical Flavoprotein Monooxygenases : Structure, Function And Role In Semaphorin Signaling / Sharon M. Kolk And R. Jeroen Pasterkamp -- Signaling Of Secreted Semaphorins In Growth Cone Steering / Sangwoo Shim And Guo-li Ming -- Modulation Of Semaphorin Signaling By Ig Superfamily Cell Adhesion Molecules / Ahmad Bechara ... [et Al.] -- Proteoglycans As Modulators Of Axon Guidance Cue Function / Joris De Wit And Joost Verhaagen -- Semaphorin Signals In Cell Adhesion And Cell Migration : Functional Role And Molecular Mechanisms / Andrea Casazza, Pietro Fazzari, And Luca Tamagnone -- Semaphorin Signaling During Cardiac Development / Toshihiko Toyofuku And Hitoshi Kikutani -- Semaphorin Signaling In Vascular And Tumor Biology / Gera Neufeld ... [et Al.]. Edited By R. Jeroen Pasterkamp. Includes Bibliographical References And Index. Front Matter....Pages i-xiv The CRMP Family of Proteins and Their Role in Sema3A Signaling....Pages 1-11 GTPases in Semaphorin Signaling....Pages 12-23 Intracellular Kinases in Semaphorin Signaling....Pages 24-37 MICAL Flavoprotein Monooxygenases: Structure, Function and Role in Semaphorin Signaling....Pages 38-51 Signaling of Secreted Semaphorins in Growth Cone Steering....Pages 52-60 Modulation of Semaphorin Signaling by Ig Superfamily Cell Adhesion Molecules....Pages 61-72 Proteoglycans as Modulators of Axon Guidance Cue Function....Pages 73-89 Semaphorin Signals in Cell Adhesion and Cell Migration: Functional Role and Molecular Mechanisms....Pages 90-108 Semaphorin Signaling During Cardiac Development....Pages 109-117 Semaphorin Signaling in Vascular and Tumor Biology....Pages 118-131 Semaphorin Signaling in the Immune System....Pages 132-144 Back Matter....Pages 145-147 The CRMP family of proteins and their role in Sema3A signaling / Eric F. Schmidt and Stephen M. Strittmatter GTPases in semaphorin signaling / Andreas W. Puschel Intracellular kinases in semaphorin signaling / Aminul Ahmed and Britta J. Eickholt Mical flavoprotein monooxygenases : structure, function, and role in semaphorin signaling / Sharon M. Kolk and R. Jeroen Pasterkamp Signaling of secreted semaphorins in growth cone steering / Sangwoo Shim and Guo-li Ming Modulation of semaphorin signaling by IG superfamily cell adhesion molecules / Ahmad Bechara ... [et al.] Proteoglycans as modulators of axon guidance cue function / Joris de Wit and Joost Verhaagen Semaphorin signals in cell adhesion and cell migration : functional role and molecular mechanisms / Andrea Casazza, Pietro Fazzari, and Luca Tamagnone.