Self And Nonself (advances In Experimental Medicine And Biology, Vol. 738)

La préface précise : "In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense--and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms--the innate and adaptive immune system--have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes... " Front Matter....Pages i-xxi The Origin of the Bacterial Immune Response....Pages 1-13 The Evolution of Self During the Transition to Multicellularity....Pages 14-30 Glyconectin Glycans as the Self-Assembling Nano-Molecular-Velcrosystem Mediating Self-Nonself Recognition and Adhesion Implicated in Evolution of Multicellularity....Pages 31-45 Neglected Biological Features in Cnidarians Self-Nonself Recognition....Pages 46-59 Intracellular Inflammatory Sensors for Foreign Invaders and Substances of Self-Origin....Pages 60-78 Nonself Perception in Plant Innate Immunity....Pages 79-107 How did Flowering Plants Learn to Avoid Blind Date Mistakes?....Pages 108-123 Signaling Pathways that Regulate Life and Cell Death: Evolution of Apoptosis in the Context of Self-Defense....Pages 124-143 Sensing Necrotic Cells....Pages 144-152 Sensing Endoplasmic Reticulum Stress....Pages 153-168 Autophagy and Self-Defense....Pages 169-184 Viruses and Host Evolution: Virus-Mediated Self Identity....Pages 185-217 The Evolution of Adaptive Immunity....Pages 218-235 Epigenetic Code and Self-Identity....Pages 236-255 Viral Immunomodulatory Proteins: Usurping Host Genes as a Survival Strategy....Pages 256-276 The Emergence of the Major Histocompatilibility Complex....Pages 277-289 MHC Signaling during Social Communication....Pages 290-313 Back Matter....Pages 315-320 The origin of the bacterial immune response / Jesús Martínez Borra, Segundo González, and Carlos López Larrea The evolution of self during the transition to multicellularity / Aurora M. Nedelcu Glyconectin glycans as the self assembling nano molecular velcrosystem mediating self nonself recognition and adhesion implicated in evolution of multicellularity / Gradimir N. Misevic, Nikola Misevic, and Octavian Popescu Neglected biological features in cnidarians self nonself recognition / Baruch Rinkevich Intracellular inflammatory sensors for foreign invaders and substances of self origin / Nao Jounai, Kouji Kobiyama, and Fumihiko Takeshita Nonself perception in plant innate immunity / Ian A. Dubery, Natasha M. Sanabria, and Ju Chi Huang How did flowering plants learn to avoid blind date mistakes self incompatibility in plants and comparisons with nonself rejection in the immune response / Philip J. Kear and Bruce McClure Signaling pathways that regulate life and cell death : evolution of apoptosis in the context of self defense / Cristina Muñoz Pinedo Sensing necrotic cells / Yasunobu Miyake and Sho Yamasaki. La préface précise : "In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense--and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms--the innate and adaptive immune system--have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes... "