Selected Aspects Of Cancer Progression: Metastasis, Apoptosis And Immune Response (cancer Growth And Progression)

The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It would be of particular interest to members of the cancer research community, especially those who are actively involved in the study of basic and translational aspects of human cancer. Specifically, this volume includes authentic subject reviews by leading experts on the following aspects: * Control of tumor cell motility * Role of tumor-cell adhesion and migration in organ-selective metastasis-formation * Tumor heterogeneity in relation to invasion and metastasis and its clinical implications * Tumor angiogenesis, angioprevention, anti-angiogenic therapies and response * Role of apoptosis in the development, progression and therapy of cancer * Role of macrophages in tumor development and metastasis * Pathways of macrophage-mediated tumor progression * Abnormal variation of immune response against cancer * Immunological aspects of Marek’s disease virus (MDV)-induced lymphoma progression * A biodynamical model of human T-cell proliferative disorders * Current methodologies for characterization of tumor directed immune response.

the Processes Of Tumor Metastasis, Apoptosis And Anti-tumor Immune Response Are Among The Most Complex Yet Rapidly Advancing Fields In The Area Of Cancer Research. This Monogaph Presents A Comprehensive Coverage Of The Recent Advances In The Various Key Concepts In These Fundamental Aspects Of Human Cancer. It Would Be Of Particular Interest To Members Of The Cancer Research Community, Especially Those Who Are Actively Involved In The Study Of Basic And Translational Aspects Of Human Cancer. Specifically, This Volume Includes Authentic Subject Reviews By Leading Experts On The Following Aspects:

• control Of Tumor Cell Motility


• role Of Tumor-cell Adhesion And Migration In Organ-selective Metastasis-formation


• tumor Heterogeneity In Relation To Invasion And Metastasis And Its Clinical Implications


• tumor Angiogenesis, Angioprevention, Anti-angiogenic Therapies And Response


• role Of Apoptosis In The Development, Progression And Therapy Of Cancer


• role Of Macrophages In Tumor Development And Metastasis


• pathways Of Macrophage-mediated Tumor Progression


• abnormal Variation Of Immune Response Against Cancer


• immunological Aspects Of Marek’s Disease Virus (mdv)-induced Lymphoma Progression


• a Biodynamical Model Of Human T-cell Proliferative Disorders


• current Methodologies For Characterization Of Tumor Directed Immune Response

Front Matter....Pages i-vi Metastasis: a current perspective....Pages 1-10 Control of cell motility during tissue invasion....Pages 11-19 Cell adhesion and invasion during secondary tumor formation: interactions between tumor cells and host organs....Pages 21-32 Genes and metastasis: experimental advances and clinical implications....Pages 33-58 The evolution of diversity within tumors and metastases....Pages 59-90 Tumor angiogenesis, antiangiogenic therapy and anti-antiangiogenesis response....Pages 91-102 Apoptosis and cancer....Pages 103-113 Macrophages in tumour development and metastasis....Pages 115-137 Classical and alternative activation of macrophages: different pathways of macrophage-mediated tumor promotion....Pages 139-156 Characterization of tumor-directed cellular immune responses in humans....Pages 157-167 Immunological aspects of Marek’s disease virus (MDV)-induced lymphoma progression....Pages 169-191 Abnormal variation of the immune response as related to cancer....Pages 193-222 A biodynamical model of human T-cell development and pathology: design, testing and validation....Pages 223-246 Back Matter....Pages 247-249 The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph, with its leading authorship, presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer.