Secretory Immunity And Infection: Proceedings Of The International Symposium On The Secretory Immune System And Caries Immunity (advances In Experimental Medicine And Biology)

The present conference is the third in a series on this topic sponsored by the NCP. Drs. HcGhee, l1estecky, Genco and Bowen are to be commended for arranging this truly comprehensive program. We are fortunate that they have been able to assemble such a wealth of expertise. Program staff considers the advice of scientists such as yourselves essential to the success of its mission. Your presentations and discussions will focus on the crucial problems to be solved in exploiting the secretory immune system to combat dental caries. The published proceedings will bring these to the attention of the research community quickly and hopefully they will stimulate new investigators to bring their talents to these problems. This meeting will, to a large extent, determine the direction of research sponsored by the NCP. Finally, I would like to thank the members of the planning committee for their dedicated efforts over the past two years, which have culminated in this symposium. Our thanks are also due to each of you, in advance, for contributing so freely to the success of this meeting. Front Matter....Pages i-xxi New Areas Arising from Studies of Secretory Immunity....Pages 1-8 Generation of Clonal and Isotype Diversity....Pages 9-17 Cellular Parameters of the IgA Response....Pages 19-28 Lymphatic Physiology and Secretory Immunity....Pages 29-34 Development of the IgA System in the Mammary Gland....Pages 35-42 Effect of Anti-IgD Serum on Immune Responses....Pages 43-51 A Common Mucosal Immunologic System Involving the Bronchus, Breast and Bowel....Pages 53-59 Discussion....Pages 61-66 Migration Pathways of T Lymphocytes in the Small Intestine....Pages 67-74 Cell-Mediated Immunity on Secretory Surfaces....Pages 75-85 Immunoglobulin a Production by Human Colostral Cells: Quantitative Aspects....Pages 87-94 Immunologic Aspects of Human Colostrum and Milk: Interaction with the Intestinal Immunity of the Neonate....Pages 95-107 Discussion....Pages 109-112 Remote-Site Stimulation of Secretory IgA Antibodies Following Bronchial and Gastric Stimulation....Pages 113-122 Development of Humoral Antibody Following the Ingestion of Soluble Protein Antigen by Passively Immunized Animals....Pages 123-132 Elimination of Escherichia Coli K88 Adhesion Determinant by Antibody in Porcine Gut and Mammary Secretions Following Oral Immunization....Pages 133-142 Cellular Aspects of the Murine Anti-Hapten IgA Response....Pages 143-150 Discussion....Pages 151-154 Characterization of Immunoglobulin-Containing Cells in the Submandibular Gland of the Rat after Local Immunization....Pages 155-164 Secretory IgA Antibodies to Enterobacterial Virulence Antigens: Their Induction and Possible Relevance....Pages 165-176 Induction of Secretory Antibodies in Humans Following Ingestion of Streptococcus Mutans ....Pages 177-184 Concept of the Local and Common Mucosal Immune Response....Pages 185-192 Discussion....Pages 193-198 T-Cell Regulation of Murine Iga Biosynthesis....Pages 199-208 Molecular-Cellular Interactions in the Secretory IgA System....Pages 209-217 Further Evidence for a Role of Secretory Component (SC) and J Chain in the Glandular Transport of IgA....Pages 219-226 Influence of Parenteral Immunization in Rabbits on the Penetrability of Oral Mucosa for Macromolecules....Pages 227-232 Role of the Liver in the Rat Intestinal s-IgA System....Pages 233-239 Transport of Oligomeric Iga of Systemic Origin Into External Secretions....Pages 241-251 Discussion....Pages 253-259 Effective Immunity to Dental Caries: Selective Induction of Secretory Immunity by Oral Administration of Streptococcus Mutans in Rodents....Pages 261-269 Cross-Protective Aspects of Glucosyltransferase Antigens in the Hamster Caries Model....Pages 271-279 Antigens of Streptococcus Mutans Implicated in Virulence — Production of Antibodies....Pages 281-292 The Effect of Cyclosporin a on Dental Caries in Rats Monoassociated with Actinomyces Viscosus NY 1....Pages 293-301 Passive Immunization with Antisera to Streptococcus Mutans in the Prevention of Caries in Rhesus Monkeys....Pages 303-315 Antibody Binding of Glucosyltransferase Enzyme Preparations from Homologous and Heterologous Serotypes of S. Mutans ....Pages 317-325 Daucus Carrota (Carrot) — A Selective Bacteriosorbent....Pages 327-333 Discussion....Pages 335-339 Studies of Secretory IgA in Caries-Resistant and Caries-Susceptible Adults....Pages 341-348 Antibodies Reacting with Streptococcus Mutans in Secretions from Minor Salivary Glands in Humans....Pages 349-354 Salivary IgA Antibodies to Antigens from Streptococcus Mutans in Human Dental Caries....Pages 355-367 Antibodies Against Streptococcus Mutans and Glucosyltransferases In Caries-Free and Caries-Active Military Recruits....Pages 369-381 Immunoglobulins and Antibodies in Plaque Fluid and Saliva in Two Populations with Contrasting Levels of Caries....Pages 383-392 Discussion....Pages 393-400 Secretory Immunity and Immunodeficiency....Pages 401-410 The Partial Isolation and Function of Salivary Factors Which Interact with the Complement System: a Possible Role in Mucosal Immunity....Pages 411-421 Discussion....Pages 423-427 Adhesion and Chemotaxis as Determinants of Bacterial Association with Mucosal Surfaces....Pages 429-437 The Role of Antigen form and the Induction of an Intestinal Immune Response to Cholera Toxin/Toxoid in Rats....Pages 439-445 Motility of the Pathogen and Intestinal Immunity of the Host in Experimental Cholera....Pages 447-455 Discussion....Pages 457-459 Prevention of Bacterial Infections of Mucosal Surfaces by Immune Secretory IgA....Pages 461-470 Studies on Oral Adjuvants Against Murine Salmonellosis....Pages 471-477 Cell Mediated Immune Responses to Bacterial Antigens on Human Mucosal Surfaces....Pages 479-488 Assay and Properties of IgA Protease of Streptococcus Sanguis ....Pages 489-495 Discussion....Pages 497-501 A Comparison of Secretory Component — Immunoglobulin Interactions Amongst Different Species....Pages 503-511 Serologic and Structural Comparisons of Rabbit IgA Allotypes....Pages 513-522 Milk Precipitins, Circulating Immune Complexes and IgA Deficiency....Pages 523-530 Regulation by Sex Hormones of Immunoglobulins in Rat Uterine and Vaginal Secretions....Pages 531-539 Discussion....Pages 541-546 Effect on Rat IgA Synthesis by Isotypic Suppression with an Anti-Rat Delta Heavy Chain Serum....Pages 547-552 Immunoglobulin A in Secretions from the Lower Human Respiratory Tract....Pages 553-564 Measurement of IgA Memory to 2,4-Dinitrophenyl (DNP) in the Sera of Adoptive Recipient Rats Using the Amplified Elisa....Pages 565-574 Human Mucosal Lymphocytes — Memory for ‘Recall’ Antigens and Non-Specific Suppression by T-Lymphocytes....Pages 575-582 Response of Anamnestic IgA-Producing Cells in the Mouse Gut After Repeated Intragastric Immunization....Pages 583-591 Detection of IgA Anti- Escherichia Coli Plasma Cells in the Intestine and Salivary Glands of Pigs Orally and Locally Infected with E. Coli ....Pages 593-600 Discussion....Pages 601-605 Lipoteichoic Acid — The Key to the Adhesiveness of Sucrose Grown Streptococcus Mutans ....Pages 607-617 Amphipathic Antigens of Oral Microorganisms — Immunogenicity and Other Biological Properties....Pages 619-628 Effect of Growth Conditions on the Antigenic Components of Streptococcus Mutans and Lactobacilli....Pages 629-637 Modification of in Vitro Adherence of Streptococcus Mutans by Plant Lectins....Pages 639-647 Search for Cross-Reacting Antigens of Oral Acidogenic Bacteria and Members of the Normal Intestinal Flora....Pages 649-653 Discussion....Pages 655-659 Genetic Alterations of Streptococcus Mutans’ Virulence....Pages 661-672 Use of Mutants in the Elucidation of Virulence of Streptococcus Mutans ....Pages 673-683 Wall Carbohydrate Antigens of A. Israelii ....Pages 685-693 Fimbriae of Actinomyces Viscosus T14V: Their Relationship to the Virulence-Associated Antigen and to Coaggregation with Streptococcus Sanguis 34....Pages 695-701 Preliminary Results in the Immunization of Irus Monkeys Against Dental Caries....Pages 703-712 Discussion....Pages 713-715 Streptococcus Mutans Dextransucrase: Phosphoglycerides and the Detection of Inhibitory Antibodies in Sera....Pages 717-725 Interaction of Streptococcus Mutans Glucosyltransferases with Antibodies....Pages 727-736 Dextran/Glucan Binding by Streptococcus Mutans : The Role of Molecular Size and Binding Site in Agglutination....Pages 737-748 Multiple Forms of Dextran-Binding Proteins from Streptococcus Mutans ....Pages 749-759 Discussion....Pages 761-763 General Discussion....Pages 765-770 Dextran Receptors as Immunogens in Caries Prophylaxis....Pages 771-781 Antigenicity and Immunogenicity of Cell-Associated Glucans from Streptococcus Mutans ....Pages 783-790 A Comparison of the Phenol Water and Rantz and Randall Teichoic Acid Antigens in Group H Streptococci....Pages 791-802 Turnover and Excretion of Streptococcal Surface Components....Pages 803-814 Discussion....Pages 815-816 Fluorescence Quantitation of S-IgA in Parotid Saliva and of S-IgA Bound to Oral Microorganisms....Pages 817-827 Antigenic Variation in Populations of Oral Streptococci....Pages 829-838 Salivary Immunoglobulins in Diseases Affecting Salivary Glands....Pages 839-847 Whole Saliva Proteases: Development of Methods for Determination of Origins....Pages 849-858 Extrachromosomal Gene Systems in Streptococcus Mutans ....Pages 859-868 Bacterial Adherence Related to Agglutination and Surface Film Formation....Pages 869-875 Discussion....Pages 877-881 Report of the Summation Committee: Recommended Areas for Future Research....Pages 883-888 Back Matter....Pages 889-905