Scientific basis of cancer chemotherapy ; edited by Georges Mathé ; [with the] opening of the Inaugural session by Maurice Schumann

Scientific Basis of Cancer Chemotherapy focuses on methods and approaches in the treatment of cancer, including detection, chemotherapeutic agents, and hormonal therapy. The selection first offers information on the detection of anti-cancer agents through screening tests and extracellular factors affecting the response of tumors to chemotherapeutic agents. Discussions focus on induced and transplanted tumors, alkylating agents, anti-folics, rate of excretion, dosage regimen, and extra-cellular deactivation. The text then elaborates on intracellular factors influencing the response of tumors to chemotherapeutic agents and chemotherapy and immune reactions. The publication ponders on dose schedules and modes of administration of chemotherapeutic agents in man and the methodology of controlled clinical trials. Topics include toxicity study in animals and clinical pharmacology; classification of chemotherapeutic agents according to their mechanism of action; and classical methodology. The book also takes a look at the biological basis of hormonal therapy of cancer and chemotherapy in the strategy of cancer treatment. The selection is highly recommended for health professionals and readers interested in cancer chemotherapy. Content: Recent Results in Cancer Research , Page i Front Matter , Page iii Copyright , Page iv Introduction , Page v Speech by Mr. Maurice Schumann, Minister for Scientific Research , Pages vii-viii Anti-Cancer Agents. Their Detection by Screening Tests and their Mechanism of Action , Pages 1-17 , T.A. CONNORS Extracellular Factors Affecting the Response of Tumours to Chemotherapeutic Agents , Pages 18-25 , J.A. DOUBLE Intracellular Factors Influencing the Response of Tumours to Chemotherapeutic Agents , Pages 26-40 , C.R. BALL Chemotherapy and Immune Reactions , Pages 41-53 , J.L. AMIEL Dose Schedules and Modes of Administration of Chemotherapeutic Agents in Man , Pages 54-61 , Y. KENIS The Methodology of Controlled Clinical Trials , Pages 62-65 , D. SCHWARTZ Biological Basis of Hormonal Therapy of Cancer , Pages 66-71 , H.J. TAGNON Operational Research in Cancer Chemotherapy. Chemotherapy in the Strategy of Cancer Treatment , Pages 72-96 , G. MATHÉ Monographs already Published , Pages ibc1-ibc2