Scientific and Engineering Principles : Proceedings of the Sixth International Fermentation Symposium Held in London, Canada, July 20-25, 1980

Advances in Biotechnology, Volume I: Scientific and Engineering Principles is the first of a series of three volumes and is based on the proceedings of the Sixth International Fermentation Symposium (IFS-6) held in London, Ontario, Canada, 20-25 July 1980. This volume is organized into 13 sections and contains 111 papers which represent about 80% of the total submitted. Section I contains papers on microbial cultures. Section II presents studies on recombinant DNA and microbial genetics. The papers in Section III deal with plant and animal cell and tissue culture. Section IV examines the microbial oxidation of hydrocarbons. Sections V and VI focus on continuous cultures and free-cell fermentation, respectively. Section VII examines process dynamics and control. Section VIII takes up computer applications in biotechnology, while Section IX covers process instrumentation and analytical methods. Section X contains papers on transport phenomena, mixing and scale-up. Section XI examines the design and operation of unconventional bioreactors. Sections XII covers fixed-, fluidized- and semi-fluidized bed bioreactors, while Section XIII presents studies on immobilization bioreactors. The volume also includes invited keynote addresses of Nobel Laureate, Professor Joshua Lederberg, and Professor Elmer L. Gaden, Jr. Abstracts of the round-table discussion on Technology Transfer and Economics, and on Biotechnology Training Programs are presented as appendices. Content: Titles of Related Interest , Page ii Front Matter , Page iii Copyright , Page iv Editorial Board , Page v PREFACE , Pages xv-xvi , Murray Moo-Young, Campbell W. Robinson, Claude Vezina GUEST EDITORIAL I - BIOCHEMICAL ENGINEERING: WHERE HAS IT BEEN AND WHERE IS IT GOING? , Pages xvii-xxi , Elmer L. Gaden Jr. GUEST EDITORIAL II - GENETICS AND INDUSTRIAL MICROBIOLOGY: STILL FURTHER HORIZONS , Pages xxiii-xxviii , Joshua Lederberg 1 - STRAIN IMPROVEMENT PROGRAMS IN ANTIBIOTIC-PRODUCING MICROORGANISMS - PRESENT AND FUTURE STRATEGIES , Pages 3-8 , Richard P. Elander 2 - NEW ORGANISMS OF ECONOMIC IMPORTANCE: THE CASE OF FRANKIA , Pages 9-14 , Hubert Lechevalier 3 - MIXED CULTURES IN INDUSTRIAL PROCESSES , Pages 15-21 , D.E.F. Harrison 4 - CULTURES AND PATENTS , Pages 23-28 , Roman Saliwanchik, Patent Lawyer 5 - PRODUCTION OF PHARMACOLOGICALLY ACTIVE AGENTS FROM MICROBIAL ORIGIN , Pages 29-33 , T. Aoyagi, H. Umezawa 6 - SCREENING OF BASIDIOMYCETES FOR THE PRODUCTION OF NEW ANTIBIOTICS , Pages 35-40 , T. Anke, W. Steglich 7 - SCREENING OF BACTERIAL ISOLATES FOR ANTIGONOCOCCAL ACTIVITIES , Pages 41-44 , J.-G. Bisaillon, R. Beaudet, S.A. Saheb, M. Sylvestre 8 - ISOLATION OF CARBOXYL PROTEINASES OF MICROBIAL ORIGIN ON PEPSTATIN-SEPHAROSE RESIN , Pages 45-49 , V. Turk, I. Kregar, I. Maljevac, V. Puizdar, M. Derenčin+ 9 - RAPID STRAIN SELECTION FOR CITRIC ACID PRODUCTION , Pages 51-55 , Arati Das, Ponty Roy 10 - USE OF CERULENIN IN SELECTING IMPROVED MUTANTS OF A DAUNORUBICIN-PRODUCING STREPTOMYCETE , Pages 57-61 , Jeffrey C. McGuire, Gail Glotfelty, Richard J. White 11 - IMPROVEMENT OF THE DAUNORUBICIN FERMENTATION REALIZED AT 10,000 LITER FERMENTOR SCALE , Pages 63-68 , B. Hamilton, R. White, J. McGuire, P. Montgomery, R. Stroshane, C. Kalita, R. Pandey 12 - STUDIES ON THE AVERMECTIN FERMENTATION , Pages 69-74 , P.A. McCann-McCormick, R.L. Monaghan, E.E. Baker, R.T. Goegelman, E.O. Stapley 13 - THE INFLUENCE OF OXYGEN CONCENTRATION ON MICROBIAL INSECTICIDE PRODUCTION , Pages 75-79 , I.O. Moraes, M.H.A. Santana, C.O. Hokka 14 - ENZYMATIC HYDROLYSIS OF SOME PENICILLINS AND CEPHALOSPORINS BY CLONED ESCHERICHIA COLI ACYLASE , Pages 83-86 , H. Mayer, P. Jaakkola, U. Schömer, A. Segner, T. Kemmer, F. Wagner 15 - EXPANSION OF THE HOST RANGE OF Pl AND Mu PHAGES AND GENE TRANSFER BETWEEN INTERGENERIC BACTERIA , Pages 87-93 , Yoshikatsu Murooka, Tokuya Harada 16 - STABILITY OF trp OPERON RECOMBINANT PLASMID IN E. coli , Pages 95-100 , Tadayuki Imanaka, Hiroshi Tsunekawa, Shuichi Aiba 17 - GENETIC CONTROL OF DIKARYOTIC FRUITING IN THE BASIDIOMYCETE PLEUROTUS OSTREATUS , (Jacq. ex Fr.) Kummer , Pages 101-106 , S.F. Li, G. Eger-Hummel 18 - ADVANCES IN PLANT CELL CULTURE TOWARDS IMPROVED YIELDS OF SECONDARY PRODUCTS (ALKALOIDS) , Pages 109-115 , F. CONSTABEL 19 - ASPECTS ON SCALE-UP AND MASS CULTIVATION OF PLANT TISSUE CULTURE , Pages 117-122 , H. Vogelmann 20 - PRESENT AND FUTURE TRENDS IN PLANT TISSUE CULTURE , Pages 123-127 , E.J. Staba, M.W. Anderson 21 - EFFECTS OF MEDIA CONSTITUENTS ON THE FORMATION OF SECONDARY PRODUCTS IN CELL SUSPENSION CULTURES OF CATHARANTHUS ROSEUS , Pages 129-133 , K.-H. Knobloch, J. Berlin 22 - HORMONAL REGULATION OF SCOPOLETIN AND SCOPOLIN PRODUCTIONS IN TOBACCO TISSUE CULTURE , Pages 135-140 , M. OKAZAKI, F. HINO, Y. MIURA 23 - ENGINEERING CHARACTERIZATION OF ANIMAL CELL AND VIRUS PRODUCTION USING CONTROLLED CHARGE MICROCARRIERS , Pages 141-146 , M. Tyo, D.I.C. Wang 24 - UPTAKE AND OXIDATION OF HYDROCARBONS BY A MUTANT DERIVED FROM ITACONATE-PRODUCING YEAST , Pages 149-153 , T. Nakahara, H. Kawashima, T. Tabuchi 25 - STUDY OF HYDROXYLASE AND ITS COMPONENTS IN CANDIDA TROPICALIS GROWN ON ALKANE , Pages 155-159 , J.C. Bertrand, M. Gilewicz, M. Zacek, D. Mansuy, E. Azoulay 26 - PLASMID INVOLVEMENT IN BACTERIAL DEGRADATION OF PHENANTHRENE , Pages 161-166 , H. Kiyohara, K. Nagao, K. Yano 27 - INDUCTION OF ENZYMES FOR n-ALKANE DEGRADATION IN TWO STRAINS OF Pseudomonas aeruginosa , Pages 167-170 , H. Weide, F. Schauer 28 - STRUCTURAL CHANGES OF THE TOL PLASMID pWWO , Pages 171-176 , Peter A. Williams, David J. Jeenes, Roger Wheatcroft 29 - UTILIZATION OF N-ALKANES BY MICROORGANISMS: BIOLOGICAL ASPECTS OF TRANSPORT , Pages 177-182 , O. Käppeli, A. Fiechter, W.R. Finnerty 30 - THE UTILITY OF CHEMOSTAT CULTURES IN STUDIES OF MICROBIAL PHYSIOLOGY , Pages 185-190 , David W. Tempest, Oense M. Neijssel 31 - CONTINUOUS CULTURE - SOME CONTEMPORARY PROBLEMS FROM ANOTHER VIEWPOINT , Pages 191-196 , P.S.S. Dawson 32 - NUTRIENT CONTROL OF GROWTH AT THE CELLULAR LEVEL: SOME STUDIES CONDUCTED WITH CANDIDA UTILIS IN CONTINUOUS PHASED CULTURE , Pages 197-202 , P.S.S. Dawson 33 - CONTINUOUS CULTURE - ITS INFLUENCE ON ENGINEERING PRACTICE , Pages 203-210 , Arthur E. Humphrey 34 - THE ENZYME ACTIVITY AS GROWTH RATE LIMITING STEP IN A CHEMOSTAT , Pages 211-214 , P. Lange 35 - SELECTION OF ESCHERICHIA COLI WITH INCREASED ENDOENZYME SYNTHESIS IN CONTINUOUS CULTURE , Pages 215-220 , B. Sikyta, P. Kyslík 36 - CONTINUOUS PROCESS FOR PRODUCTION OF CITRIC ACID , Pages 221-227 , B. Kristiansen, R. Charley 37 - KINETICS OF VIRUS REPLICATION AND GLUCOAMYLASE BIOSYNTHESIS IN ASPERGILLUS NIGER REPEATED FED - BATCH CULTURE , Pages 229-234 , R. Valinger, J. Beljak, M. Bošnjak, M. ćuršic, Lj. Vitale 38 - AUTO-SELECTION OF VERY RAPIDLY GROWING MICROORGANISMS , Pages 235-241 , H.R. Bungay, L.S. Clesceri, N.A. Andrianas 39 - GEL-FORMING EXOPOLYSACCHARIDE PRODUCTION BY ALCALIGENES FAECALIS GROWN IN NITROGEN-LIMITED CONTINUOUS CULTURE , Pages 243-248 , K. Railton, D. Farago, C.R. MacKenzie, G.R. Lawford, J. Pik, H.G. Lawford 40 - NEW DEVELOPMENTS IN THE ELUCIDATION OF THE MECHANISMS OF THE PASTEUR AND CRABTREE EFFECTS IN BACTERIA , Pages 249-254 , H.W. Doelle 41 - THE CRABTREE EFFECT IN SACCHAROMYCES CEREVISIAE - PRIMARY CONTROL MECHANISM OR TRANSIENT? , Pages 255-260 , J.P. Barford, P.M. Jeffery, R.J. Hall 42 - REGULATORY ASPECTS IN YEAST METABOLISM , Pages 261-266 , A. Fiechter 43 - GROWTH OF HANSENULA POLYMORPHA ON MIXED SUBSTRATES AND REGULATION OF ALCOHOL OXIDASE SYNTHESIS , Pages 267-269 , L. Eggeling, H. Sahm 44 - A QUANTITATIVE DESCRIPTION OF THE GROWTH OF SACCHAROMYCES CEREVISIAE CBS 426 IN CONTINUOUS CULTURES ON A MIXTURE OF TWO CARBON SOURCES; , Pages 271-276 , Hermine E. de Kok, J.A. Roels 45 - CELLULAR YIELDS AND MAINTENANCE REQUIREMENTS OF Alcaligenes Eutrophus DURING HYDROGEN OXIDATION , Pages 277-280 , C.G. Friedrich 46 - LIGHT SUPPLY AND QUANTUM EFFICIENCIES IN A MODEL REACTOR FOR CONTINUOUS PHOTOTROPHIC GROWTH , Pages 281-286 , F. Göbel 47 - PROPERTIES OF THE GREEN ALGA CHLOROGONIUM ELONGATUM DURING LIGHT-LIMITED CONTINUOUS CULTURE IN THE PHAUXOSTAT , Pages 287-293 , K. Kreuzberg, W. Hempfling 48 - OPTIMAL CONDITIONS FOR PRODUCTION OF CEPHALOSPORIN C IN FED-BATCH CULTURE , Pages 297-302 , M. Matsumura, T. Imanaka, T. Yoshida, H. Taguchi 49 - KINETICS OF SUBSTRATE UTILIZATION IN REPEATED FED BATCH CULTURE AND FITTING COMPUTER SIMULATION DATA TO EXPERIMENTAL DATA OF ANTIBIOTIC BIOSYNTHESIS , Pages 303-308 , M. Bošnjak, V. Topolovec, A. Stroj, V. Johanides 50 - A MODEL FOR THE GROWTH AND PRODUCT KINETICS OF FACULTATIVE ANAEROBES BASED ON ATP SYNTHESIS AND CONSUMPTION , Pages 309-313 , N.B. Jansen, M.C. Flickinger, G.T. Tsao 51 - AN UNSTRUCTURED MODEL OF ALGAL GROWTH IN CONTINUOUS CULTURE , Pages 315-321 , H.J.G. ten Hoopen, J.A. Roels, J.M. van Gemert, P.J. Nobel, A. Fuchs 52 - THE DEVELOPMENT OF A SEMI-SOLID FERMENTATION SYSTEM FOR THE PRODUCTION OF LYSINE-ENRICHED YEAST AND ETHANOL , Pages 323-328 , R.D. Tanner, C.-J. Wei, J. Woodward 53 - EFFECT OF OXYGEN ON AMINO ACIDS FERMENTATION , Pages 329-333 , Y. Hirose, H. Shibai 54 - THE INFLUENCE OF LOW DISSOLVED OXYGEN LEVELS IN FERMENTORS ON ETHANOL PRODUCTION BY CANDIDA TROPICALIS , Pages 335-338 , V. Maric, A. Einsele 55 - EFFECT OF WATER ACTIVITY ON MICROBIAL GROWTH , Pages 339-344 , A.A. Esener, G. Bol, N.W.F. Kossen, J.A. Roels 56 - DEATH RATES OF BACTERIAL SPORES AT HIGH TEMPERATURE IN A CONTINUOUS STIRRED TANK REACTOR , Pages 345-349 , BIREN SRIMANI, REINHOLD STAHL, MARCEL LONCIN 57 - ANALYSIS OF BASIC PRINCIPLES OF FERMENTATION PROCESS CONTROL , Pages 353-358 , I.M. Chirkov, B.Ya. Lokshin, A.V. Kulakov 58 - PRODUCTION OF CELLULASE IN FED-BATCH CULTURE , Pages 359-364 , T. Waki, K. Suga, K. Ichikawa 59 - DYNAMICS AND CONTROL OF A BIOLOGICAL PHENOL WASTEWATER TREATMENT REACTOR , Pages 365-370 , S. Yongaçoglu, K. Toda, J.E. Prenosil, I.J. Dunn 60 - THE REDOX POTENTIAL, A HITHERTO SELDOM USED PARAMETER IN FERMENTATION SYSTEMS , Pages 371-376 , L. Kjaergaard, B.B. Joergensen 61 - DETERMINATION OF KINETIC PROCESS PARAMETERS BY DYNAMIC METHODS TAKING INTO ACCOUT THE INERTIA OF MEASURING INSTRUMENT , Pages 377-383 , R. Błaszczyk, H. Michalski, G. Szewczyk, A. Wieczorek 62 - APPLICATION OF EXPERIMENTAL METHODS TO IDENTIFY PROCESS DYNAMICS OF FERMENTATION PROCESSES , Pages 385-390 , M. Meiners, W. Rapmundt 63 - DIRECT MONITORING OF A FERMENTATION IN A COMPUTER-MASS SPECTROMETER-FERMENTOR SYSTEM , Pages 393-398 , E. Pungor Jr., E. Schaefer, J.C. Weaver, C.L. Cooney 64 - STATE ESTIMATION FOR COMPUTER CONTROL OF BIOCHEMICAL REACTORS , Pages 399-406 , Gregory Stephanopoulos, Ka-Yiu San 65 - AN APPROACH TO ON-LINE OPTIMIZATION OF BIOMASS PRODUCTION IN CONTINUOUS PROCESSES , Pages 407-412 , A. Bernard, M. Cordonnier, J.M. Lebeault 66 - AUTOMATIC CONTROL OF DISSOLVED OXYGEN CONCENTRATION WITH MICROCOMPUTER , Pages 413-417 , T. Kobayashi, T. Yano, S. Shimizu 67 - ETHANOL-AND RQ-BASED COMPUTER CONTROL IN FED BATCH CULTURE OF BAKER'S YEAST , Pages 419-424 , W. Woehrer, W. Hampel, M. Roehr 68 - PROGRESS WITH COMPUTER-COUPLED MAMMALIAN CELL CULTURE INVESTIGATIONS , Pages 425-430 , Robert J. Fleischaker, Donald J. Giard, James Weaver, Anthony J. Sinskey 69 - A NEW SENSOR, THE “FILTRATION PROBE”, TO MONITOR AND CONTROL ANTIBIOTIC FERMENTATIONS , Pages 433-438 , Eirik Nestaas, Daniel I.C. Wang 70 - A POROUS MEMBRANE-CARRIER GAS MEASUREMENT SYSTEM FOR DISSOLVED GASES AND VOLATILES IN FERMENTATION SYSTEMS , Pages 439-444 , E. Heinzle, O. Bolzern, I.J. Dunn, J.R. Bourne 71 - FERMENTER MONITORING AND CONTROL BY ENZYME THERMISTORS , Pages 445-451 , B. Danielsson, C.F. Mandenius, F. Winquist, B. Mattiasson, K. Mosbach 72 - MEASUREMENT OF THE SOLUBILITY OF OXYGEN DURING FERMENTATIONS , Pages 453-455 , J. Lehmann, J. Nothnagel, H. Piehl, R. Schultze, W. Steven 73 - DETERMINATION OF ADENOSINE NUCLEOTIDES WITH LUCIFERIN/LUCIFERASE FROM CRUDE FIREFLY LANTERN EXTRACT ON A BIOLUMINESCENCE ANALYZER , Pages 457-462 , Karl-Ludwig Schimz, Birgit Rütten, Marlies Tretter 74 - PHYSICAL TRANSPORT PHENOMENA IN BUBBLE COLUMN BIOREACTORS - I. GAS-LIQUID MASS TRANSFER , Pages 465-470 , W.-D. Deckwer 75 - PHYSICAL TRANSPORT PHENOMENA IN BUBBLE COLUMN BIOREACTORS - II. LIQUID-SOLID MASS TRANSFER, MIXING AND HEAT TRANSFER , Pages 471-476 , W.-D. Deckwer 76 - THE TWO-ZONE MODEL: A QUANTITATIVE DESCRIPTION OF THE OXYGEN MASS TRANSFER IN BUBBLE COLUMNS AND THREE-PHASE FLUIDIZED BEDS , Pages 477-482 , M. Alvarez-Cuenca, M.A. Nerenberg 77 - TURBINE AGITATED GAS DISPERSION: POWER, FLOODING, AND HOLD-UP , Pages 483-488 , D.S. Dickey 78 - BUBBLE COALESCENCE AND BREAK-UP IN FERMENTATIONS , Pages 489-496,496A,496B , Christopher McBride, James Walter, Harvey W. Blanch, T.W.F. Russell 79 - GAS-LIQUID CONTACTING IN HIGHLY VISCOUS LIQUIDS , Pages 497-502 , H.-J. Henzler 80 - POWER AND HOLD-UP IN THE MIXING OF AERATED HIGHLY VISCOUS NON-NEWTONIAN FLUIDS , Pages 503-509 , J. Solomon, A.W. Nienow, G.W. Pace 81 - GAS ABSORPTION WITH SIMULTANEOUS BIOCHEMICAL REACTION , Pages 511-516 , E. Alper, Y. Serpemen, W.-D. Deckwer 82 - SOME SCALE-UP CONSIDERATIONS FOR FERMENTATION MIXERS , Pages 517-522 , James Y. Oldshue, Vice-President 83 - CIRCULATION TIMES OF VARIOUS FLUIDS IN STIRRED FERMENTORS , Pages 523-528 , S. Mukataka, H. Kataoka, J. Takahashi 84 - MODELLING AND SCALE-UP OF ANAEROBIC CONVERSION OF DISSOLVED FATTY ACIDS , Pages 529-535 , J.W. BUIJS, P.M. HEERTJES, R.R. van der MEER 85 - HIGH PRODUCTIVITY ANAEROBIC FERMENTATION WITH DENSE CELL CULTURE , Pages 539-545 , C.R. Wilke, B. Maiorella 86 - MASS TRANSFER AND LIQUID MIXING IN EXTERNAL-CIRCULATION-LOOP CONTACTORS , Pages 547-552 , R.A. Bello, C.W. Robinson, M. Moo-Young 87 - GAS-LIQUID DISPERSION CHARACTERISTICS IN AIRLIFT FERMENTORS , Pages 553-558 , Larry E. Erickson, Vasanti Deshpande 88 - LIQUID VELOCITY AS AN IMPORTANT DESIGN PARAMETER FOR AIRLIFT LOOP-FERMENTORS , Pages 559-564 , U. Onken, P. Weiland 89 - SINGLE AND MULTI-STAGE COUNTERCURRENT BUBBLE COLUMN LOOP REACTOR PERFORMANCES , Pages 565-571 , J. Voigt, K. Schügerl 90 - PENICILLIN PRODUCTION IN A BUBBLE COLUMN AIR LIFT LOOP REACTOR , Pages 573-579 , B. Koenig, K. Schügerl, C. Seewald 91 - OXYGEN TRANSFER AND BIOLOGICAL EFFECTS IN A DEEP-TANK AERATION SYSTEM , Pages 581-587 , T. Takamatsu, S. Shioya, H. Nakatani, T. Fujimoto, T. Kawasugi 92 - EFFECTIVENESS OF ENERGY INTRODUCED INTO FERMENTORS , Pages 589-593 , V.V. Krikis, U.E. Viesturs 93 - NOVEL REACTOR CONFIGURATION FOR SMALL SCALE MICROBIOLOGICAL LEACHING , Pages 595-600 , V. Sanmugasunderam, D.W. Duncan, R.M.R. Branion 94 - ON-LINE EXTRACTION FERMENTATION PROCESSES , Pages 601-607 , H.Y. Wang, L.A. Kominek, J.L. Jost 95 - MODIFICATION OF NON-NEWTONIAN MYCELIAL FERMENTATION BROTH THROUGH CONFINEMENT OF GROWTH USING MICROSCOPIC BEADS , Pages 609-615 , K. Gbewonyo, D.I.C. Wang 96 - OPTIMUM OPERATION POLICY FOR A FIXED AND MOVING BED REACTOR WITH DEACTIVATING ENZYME CATALYST: OPTIMUM TEMPERATURE AND OPTIMAL TEMPERATURE PROFILE , Pages 619-625 , J.E. Prenosil, K. Toda 97 - ETHANOL FERMENTATION IN A YEAST IMMOBILIZED COLUMN FERMENTOR , Pages 627-633 , Mehmet A. Gencer, Rajakkannu Mutharasan 98 - FLUIDIZATION PRINCIPLES AND APPLICATIONS TO BIOTECHNOLOGY , Pages 635-641 , C.G.J. Baker, A. Margaritis, M.A. Bergougnou 99 - OXYGEN TRANSFER IN THREE PHASE FLUIDIZED BEDS , Pages 643-650 , L.T. Fan, M.P. Newcomer 100 - TAPERED FLUIDIZED BED BIOREACTORS FOR ENVIRONMENTAL CONTROL AND FUEL PRODUCTION , Pages 651-656 , Charles D. Scott, Charles W. Hancher, Edward J. Arcuri 101 - FLUIDIZED BED REACTOR FOR THE PRODUCTION OF METHANE FROM SUGAR CANE BAGASSE , Pages 657-662 , F. Siñeriz, H.F. Díaz, P.R. Córdoba 102 - SEMIFLUIDIZED BED BIOREACTOR , Pages 663-669 , L.T. Fan, Edward H. Hsu 103 - OPTIMAL OPERATION AND REPLACEMENT POLICIES FOR DECAYING IMMOBILIZED ENZYME , Pages 673-678 , K. Suga, K.C. Chen, H. Taguchi 104 - DEXTRAN PRODUCTION BY FREE AND IMMOBILIZED DEXTRANSUCRASE , Pages 679-684 , P. MONSAN, A. LOPEZ 105 - IMMOBILIZED β-GLUCANASE IN BREWING , Pages 685-690 , Yu-Yen Linko, Helena Kautola, P. Linko 106 - THE EFFECTS OF SOLVENTS ON THE HYDROLYSIS OF LIPIDS BY FREE AND IMMOBILIZED MICROBIAL LIPASE , Pages 691-697 , S.S. Çelebi, T. Uçar, M.A. Çaglar 107 - IMMOBILIZATION OF A Penicillium duponti PROTEOLYTIC ENZYME AND ITS APPLICATION IN SOLUBILIZATION OF SOYBEAN PROTEIN IN A SPIRAL-WOUND RECYCLE REACTOR , Pages 699-704 , B. Adu-Amankwa, A. Constantinides 108 - GLUCOAMYLASE HOLLOW-FIBER REACTORS , Pages 705-710 , A. MARC, J. CAUMON, J.M. ENGASSER 109 - IMMOBILIZED LIVE CELLS , Pages 711-716 , P. Linko 110 - MAGNETIC IMMOBILIZED MICROORGANISMS , Pages 717-720 , P.O. Larsson, S. Birnbaum, K. Mosbach 111 - MACROMOLECULAR NAD + -DERIVATIVE OF HIGH COENZYME ACTIVITY AND ITS APPLICATION FOR A MODEL REACTION , Pages 721-727 , H. Okada, I. Urabe, M. Muramatsu, S. Furukawa APPENDIX IA - OVERVIEW OF TECHNOLOGY TRANSFER AND ECONOMICS I: Report on Roundtable Discussions , Pages 731-738 , L. Hepner APPENDIX IB - OVERVIEW OF TECHNOLOGY TRANSFER AND ECONOMICS II: Report on Roundtable Discussions , Pages 739-748 , G. Hamer APPENDIX II - OVERVIEW OF TRAINING PROGRAMS IN BIOTECHNOLOGY AND BIOCHEMICAL ENGINEERING: Collation of Abstracts of Roundtable Discussions , Pages 749-752 , M. Moo-Young CONTENTS OF VOLUME II: FUELS, CHEMICALS, FOODS AND WASTE TREATMENT , Pages 755-760 CONTENTS OF VOLUME III: FERMENTATION PRODUCTS , Pages 761-766 CONTENTS OF CURRENT DEVELOPMENTS IN YEAST RESEARCH , Pages 767-772 Author Index , Pages 773-775 Subject Index , Pages 777-780 Advances in Biotechnology, Volume III: Fermentation Products is the third of a series of three volumes and is based on the proceedings of the Sixth International Fermentation Symposium (IFS-6) held in London, Ontario, Canada, 20-25 July 1980. This volume contains 87 papers organized into nine sections. The papers under Section I deal with developments in the field of secondary metabolism (functions of secondary metabolites in the producing organisms; roles of plasmids in the biosynthesis of secondary metabolites; and protoplast fusion in industrial microorganisms). Sections II to VII examine the fermentation of antibiotics; amino acids, vitamins, and nucleotides; microbial enzymes; products from immobilized cells and enzymes; mycotoxins; and biopolymers. The final two sections present studies on bioconversions. The volume also includes the invited keynote address of Professor Hamao Umezawa''Problems and Trends in the Development of New Antibiotics and Other Useful Microbial Products''. This volume will be a valuable resource for students and researchers in industrial microbiology, biochemical engineering and related areas, as well as managers of biotechnology.