Schottenfeld and Fraumeni cancer epidemiology and prevention

**"The definitive reference for budding and experienced cancer epidemiologists alike."** **__-American Journal of Epidemiology__****"Practitioners in epidemiology and oncology will find immense value in this."** **__-JAMA__**Since its initial publication in 1982, CANCER EPIDEMIOLOGY AND PREVENTION has served as the premier reference work for students and professionals working to understand the causes and prevention of cancer in humans. Now revised for the first time in more than a decade, this fourth edition provides a comprehensive summary of the global patterns of cancer incidence and mortality, current understanding of the major causal determinants, and a rationale for preventive interventions. Special attention is paid to molecular epidemiologic approaches that address the wider role of genetic predisposition and gene-environment interactions in cancer etiology and pathogenesis. New and timely chapters on environmental and social-epidemiologic factors include: · The role of social class disparities· The role of obesity and physical inactivity· The potential effects of electromagnetic fields and radiofrequency radiation· The principles of cancer chemopreventionFor both seasoned professionals and newer generations of students and researchers, this fourth edition of CANCER EPIDEMIOLOGY AND PREVENTION remains the authority in the field -- a work of distinction that every lab, library, student, professional, or researcher should have close at hand. Cover 1 Schottenfeld and Fraumeni Cancer Epidemiology and Prevention 4 Copyright 5 Contents 6 Acknowledgments 10 Contributors 12 Preface 20 1. Introduction 22 I Basic Concepts 28 2. Biology of Neoplasia 30 3. Morphological and Molecular Classification of Human Cancer 40 4. Genomic Landscape of Cancer: Insights for Epidemiologists 64 5. Genetic Epidemiology of Cancer 74 6. Application of Biomarkers in Cancer Epidemiology 98 7. Causal Inference in Cancer Epidemiology 118 II The Magnitude of Cancer 126 8. Patterns of Cancer Incidence, Mortality, and Survival 128 9. Socioeconomic Disparities in Cancer Incidence and Mortality 162 10. The Economic Burden of Cancer in the United States 190 III The Causes of Cancer 204 11. Tobacco 206 12. Alcohol and Cancer Risk 234 13. Ionizing Radiation 248 14. Ultraviolet Radiation 270 15. Electromagnetic Fields 280 16. Occupational Cancer 296 17. Air Pollution 312 18. Water Contaminants 326 19. Diet and Nutrition 350 20. Obesity and Body Composition 372 21. Physical Activity, Sedentary Behaviors, and Risk of Cancer 398 22. Hormones and Cancer 416 23. Pharmaceutical Drugs Other Than Hormones 432 24. Infectious Agents 454 25. Immunologic Factors 482 IV Cancers by Tissue of Origin 508 26. Nasopharyngeal Cancer 510 27. Cancer of the Larynx 526 28. Lung Cancer 540 29. Oral Cavity, Oropharynx, Lip, and Salivary Glands 564 30. Esophageal Cancer 600 31. Stomach Cancer 614 32. Cancer of the Pancreas 632 33. Liver Cancer 656 34. Biliary Tract Cancer 682 35. Small Intestine Cancer 692 36. Cancers of the Colon and Rectum 702 37. Anal Cancer 728 38. Leukemias 736 39. Hodgkin Lymphoma 766 40. The Non-​Hodgkin Lymphomas 788 41. Multiple Myeloma 818 42. Bone Cancers 836 43. Soft Tissue Sarcoma 850 44. Thyroid Cancer 860 45. Breast Cancer 882 46. Ovarian Cancer 910 47. Endometrial Cancer 930 48. Cervical Cancer 946 49. Vulvar and Vaginal Cancers 968 50. Choriocarcinoma 974 51. Renal Cancer 982 52. Bladder Cancer 998 53. Prostate Cancer 1018 54. Testicular Cancer 1040 55. Penile Cancer 1050 56. Nervous System 1060 57. Melanoma 1082 58. Keratinocyte Cancers 1110 59. Childhood Cancers 1140 60. Multiple Primary Cancers 1176 V Cancer Prevention and Control 1212 61. Framework for Understanding Cancer Prevention 1214 62. Primary Prevention of Cancer 1226 62.1. Tobacco Control 1228 62.2. Prevention of Obesity and Physical Inactivity 1232 62.3. Prevention of Infection-​Related Cancers 1238 62.4. Protection from Ultraviolet Radiation 1242 62.5. Preventive Therapy 1250 62.6. Regulation 1260 63. Cancer Screening 1276 Index 1292 "The definitive reference for budding and experienced cancer epidemiologists alike." -American Journal of Epidemiology "Practitioners in epidemiology and oncology will find immense value in this." -JAMA Since its initial publication in 1982, CANCER EPIDEMIOLOGY AND PREVENTION has served as the premier reference work for students and professionals working to understand the causes and prevention of cancer in humans. Now revised for the first time in more than a decade, this fourth edition provides a comprehensive summary of the global patterns of cancer incidence and mortality, current understanding of the major causal determinants, and a rationale for preventive interventions. Special attention is paid to molecular epidemiologic approaches that address the wider role of genetic predisposition and gene-environment interactions in cancer etiology and pathogenesis. New and timely chapters on environmental and social-epidemiologic factors include: · The role of social class disparities · The role of obesity and physical inactivity · The potential effects of electromagnetic fields and radiofrequency radiation · The principles of cancer chemoprevention For both seasoned professionals and newer generations of students and researchers, this fourth edition of CANCER EPIDEMIOLOGY AND PREVENTION remains the authority in the field -- a work of distinction that every lab, library, student, professional, or researcher should have close at hand. Lead Editor, Michael J. Thun ; Co-editors, Martha S. Linet, James R. Cerhan, Christopher Haiman, David Schottenfeld ; Project Manager, Annelie M. Landgren. Preceded By Cancer Epidemiology And Prevention / Edited By David Schottenfeld, Joseph F. Fraumeni Jr. 3rd Ed. 2006. Includes Bibliographical References And Index.