Schiff's Diseases of the Liver: Schiff/Schiff's Diseases of the Liver

For over 50 years covering 10 previous editions, __Schiff's Diseases of the Liver__ has provided hepatologists with an outstanding evidence-based clinical reference work covering all aspects of liver disease, and is without doubt one of the world's leading hepatology textbooks. Now fully revised and updated, it will serve as your first-stop reference for today's demanding clinical situations. With a strong clinical focus, __Schiff's Diseases of the Liver__ covers anatomy, pathology, testing, imaging, and effects of liver disease on other organs, before moving on to sections that address specific diseases and clinical syndromes. Its enormous appeal has been due to the clarity of text, combined with the sheer thoroughness of its breadth of content. Key features include: • An attractive full color design throughout • Informative section overviews for each section • Concise key concepts box in every chapter • Treatment guidelines and management algorithms for every disease • A full liver transplant section This 11th edition sees all existing chapters fully revised and refreshed with the very latest in clinical information from the world's leading hepatologists. Also new to this edition is a companion website containing a variety of important extra materials, including: • Approximately 100 multiple choice questions of the standard used in ABIM board exams in gastroenterology, to allow the user to self-assess their clinical knowledge • All 450+ figures from the book in a high-quality, fully transportable and downloadable electronic format • High-quality video clips of a variety of surgical procedures, all fully linked to the text • 35 case studies featuring real-life clinical scenarios. __Schiff's Diseases of the Liver__ remains the key textbook for all gastroenterologists and hepatologists, in training or fully qualified, managing patients with liver disease. book cover 1 book cover 1 Introduction 2 front matter 2 editors 4 copyright 5 Contents 6 List of Contributors 9 Foreword 13 Preface 14 PART I Overview: Clinical Fundamentals of Hepatology 15 CHAPTER 1History Taking and Physical Examinationfor the Patient with Liver Disease 16 CHAPTER 2Laboratory Tests 30 CHAPTER 3Liver Biopsy and Laparoscopy 57 CHAPTER 4Noninvasive and Invasive Imagingof the Liver and Biliary Tract 71 5-25 CHAP 100 PART I IGeneral Considerations 100 CHAPTER 5 Physioanatomic Considerations 101 CHAPTER 6 Bilirubin Metabolism and Jaundice 132 CHAPTER 7 164 Blank Page 164 CHAPTER 8 Mechanisms of Liver Injury 165 CHAPTER 9 Hepatic Manifestations of Systemic Disorders 181 CHAPTER 10 Hepatobiliary Complications of HematopoieticCell Transplantation 204 CHAPTER 11 The Liver in Pregnancy 220 PART I I IConsequences of Liver Disease 243 CHAPTER 12Hepatic Fibrosis 244 CHAPTER 13 Preoperative Evaluation of the Patientwith Liver Disease 263 CHAPTER 14 Portal Hypertension: Nonsurgical andSurgical Management 273 CHAPTER 15 Renal Complications of Liver Diseaseand the Hepatorenal Syndrome 309 CHAPTER 16 Pulmonary Manifestations of Liver Disease 328 CHAPTER 17 Ascites and Spontaneous Bacterial Peritonitis 340 CHAPTER 18 Hepatic Encephalopathy 368 CHAPTER 19 Acute Liver Failure 392 PART IVCholestatic Disorders 421 CHAPTER 20 Primary Sclerosing Cholangitis 422 CHAPTER 21 Primary Biliary Cirrhosis 435 CHAPTER 22 Autoimmune Hepatitis 453 PART V Viral Hepatitis 463 CHAPTER 23Hepatitis A and E 465 CHAPTER 24Hepatitis B and D 481 CHAPTER 25 Hepatitis C 526 26-49 597 PART VIAlcohol and Drug-induced Liver Disease 597 CHAPTER 26Alcoholic Liver Disease 600 CHAPTER 27Drug-induced Liver Disease 646 CHAPTER 28Mechanisms of Drug-induced Liver Injury 727 PART VI IGenetic and Metabolic Disease 745 CHAPTER 29Wilson Disease 746 CHAPTER 30Hemochromatosis and Iron Storage Disorders 766 CHAPTER 31Alpha-1 Antitrypsin Deficiency 786 CHAPTER 32Nonalcoholic Fatty Liver Disease 809 PART VIIIVascular Diseases of the Liver 849 CHAPTER 33Vascular Diseases of the Liver 850 CHAPTER 34The Liver in Circulatory Failure 863 PART IXBenign and Malignant Tumors; Cystic Disorders 874 CHAPTER 35Benign Tumors, Nodules, and Cystic Diseasesof the Liver 875 CHAPTER 36Hepatocellular Carcinoma 916 CHAPTER 37Surgical Options in Liver Cancers 928 PART XInfectious and Granulomatous Disease 944 CHAPTER 38Amoebic and Pyogenic Liver Abscesses 945 CHAPTER 39Parasitic Diseases 953 CHAPTER 40Granulomas of the Liver 970 CHAPTER 41Hepatobiliary Manifestations of HumanImmunodeficiency Virus 996 PART XIElements of Liver Transplantation 1019 CHAPTER 42Selection and Timing of Liver Transplantation 1020 CHAPTER 43Immunosuppression: The Global Picture 1031 CHAPTER 44The First Six Months FollowingLiver Transplantation 1045 CHAPTER 45Long-term Management of the LiverTransplant Patient 1059 CHAPTER 46The Liver Transplant Procedure 1072 CHAPTER 47Recurrent Disease FollowingLiver Transplantation 1087 CHAPTER 48The Role of Retransplantation 1107 CHAPTER 49Controversies in Liver Transplantation 1118 APPENDIXMultiple Choice Answers 1133 Index 1143 Companion website 1185

For over 50 years covering 10 previous editions, Schiff's Diseases of the Liver has provided hepatologists with an outstanding evidence-based clinical reference work covering all aspects of liver disease, and is without doubt one of the world’s leading hepatology textbooks.  Now fully revised and updated, it will serve as your first-stop reference for today’s demanding clinical situations.

With a strong clinical focus, Schiff’s Diseases of the Liver covers anatomy, pathology, testing, imaging, and effects of liver disease on other organs, before moving on to sections that address specific diseases and clinical syndromes.  Its enormous appeal has been due to the clarity of text, combined with the sheer thoroughness of its breadth of content. Key features include:

• An attractive full color design throughout
• Informative section overviews for each section
• Concise key concepts box in every chapter
• Treatment guidelines and management algorithms for every disease
• A full liver transplant section

This 11th edition sees all existing chapters fully revised and refreshed with the very latest in clinical information from the world’s leading hepatologists. Also new to this edition is a companion website containing a variety of important extra materials, including:

• Approximately 100 multiple choice questions of the standard used in ABIM board exams in gastroenterology, to allow the user to self-assess their clinical knowledge 
• All 450+ figures from the book in a high-quality, fully transportable and downloadable electronic format
• High-quality video clips of a variety of surgical procedures, all fully linked to the text
• 35 case studies featuring real-life clinical scenarios. 

Schiff’s Diseases of the Liver remains the key textbook for all gastroenterologists and hepatologists, in training or fully qualified, managing patients with liver disease.

The book contains predominantly black-and-white illustrations, with some color illustrations.

The name Schiff is synonymous with hepatology. Leon Schiff co-founded the AASLD in 1950 and was the main editor of this iconic book for the first 7 editions. Following Leon Schiff's death, his son Gene Schiff has taken on the lead editor role, and this 11th edition will be the 4th under his guidance. This edition focus on hepatology, it covers anatomy, pathology, testing, imaging, and effects of liver disease on other organs, before moving on to sections that address specific diseases and clinical syndromes. Sections begin with a clear overview and chapters with a key concepts section that helps the reader quickly assimilate the most noteworthy information. Its enormous appeal has been due clarity of text, combined with a sheer thoroughness in its breadth of content. The inclusion of these accessory features, as well as the fully updated chapter revisions, fresh contributor list, and the streamlined, more accessible one volume book will ensure that this book is as relevant as ever, that it always seeks to improve and evolve with each new edition, and that it retains its place as the key textbook for gastroenterologists and hepatologists, and specialist GI trainees treating patients with liver disease