Salivary Gland Development and Regeneration : Advances in Research and Clinical Approaches to Functional Restoration

This book provides a comprehensive update on the latest information and knowledge which emerged from translational and basic science research endeavors, targeting the regeneration of salivary glands. The coverage includes salivary gland growth and development, stem cell therapy, bioengineering of salivary glands, and perspectives on and practical approaches to restoration of secretory function. More specifically, among the individual topics addressed are the various types of stem cell of value for cell replacement therapy, technological advances with respect to 3D printing, gene therapy, organ culture of salivary glands, and surgical aspects of the feasibility and practicality of transplantation. Readers will find helpful practical guidance on functional restorations of damaged salivary glands and stimulating insights into potential future directions in salivary gland regeneration research. The authors are all acknowledged experts from a range of academic and clinical backgrounds. Accordingly, the book will be of interest not only to clinicians, such as general dental practitioners, oral medicine specialists, and surgeons who manage dry mouth patients, but also to biomedical engineers, stem cell researchers, and transplant surgeons. Front Matter....Pages i-xiii Front Matter....Pages 1-1 Implications of Salivary Gland Developmental Mechanisms for the Regeneration of Adult Damaged Tissues....Pages 3-22 Systems Biology: Salivary Gland Development, Disease, and Regenerative Medicine....Pages 23-44 Mucins in Salivary Gland Development, Regeneration, and Disease....Pages 45-71 Front Matter....Pages 73-73 Histologic Changes in the Salivary Glands Following Radiation Therapy....Pages 75-91 Adult Stem Cell Therapy for Salivary Glands, with a Special Emphasis on Mesenchymal Stem Cells....Pages 93-102 Directed Cell Differentiation by Inductive Signals in Salivary Gland Regeneration: Lessons Learned from Pancreas and Liver Regeneration....Pages 103-129 Front Matter....Pages 131-131 Current Cell Models for Bioengineering Salivary Glands....Pages 133-144 Matrix Biology of the Salivary Gland: A Guide for Tissue Engineering....Pages 145-171 3D Printing Technology in Craniofacial Surgery and Salivary Gland Regeneration....Pages 173-191 Functional Salivary Gland Regeneration by Organ Replacement Therapy....Pages 193-203 Front Matter....Pages 205-205 Regulation of Salivary Secretion....Pages 207-215 Salivary Gland Gene Therapy in Experimental and Clinical Trials....Pages 217-228 Surgical Management of Salivary Gland Disease....Pages 229-263