Safety of Biologics Therapy : Monoclonal Antibodies, Cytokines, Fusion Proteins, Hormones, Enzymes, Coagulation Proteins, Vaccines, Botulinum Toxins

This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, __Safety of Biologics Therapy__ examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences. Front Matter....Pages i-xxi Approved Biologics Used for Therapy and Their Adverse Effects....Pages 1-27 Monoclonal Antibodies: Introduction....Pages 29-56 Monoclonal Antibodies Approved for Cancer Therapy....Pages 57-140 Other Approved Therapeutic Monoclonal Antibodies....Pages 141-215 Cytokines....Pages 217-261 Fusion Proteins....Pages 263-307 Peptide Hormones....Pages 309-400 Glycoprotein Hormones....Pages 401-417 Enzymes Approved for Therapy....Pages 419-477 Blood Coagulation....Pages 479-513 Vaccines....Pages 515-557 Botulinum Neurotoxins....Pages 559-585 Biosimilars....Pages 587-596 Back Matter....Pages 597-610