Safety Evaluation of Certain Food Additives and Contaminants: Prepared by the Sixty-seventh Meeting of the Joint Fao Who Expert Committee on Food Additives (Who Food Additives)

The toxicological monographs in this volume summarize the safety and intake data on five food additives (annatto extracts lycopene synthetic and lycopene from Blakeslea trispora and propyl paraben). This volume also contains monographs summarizing toxicological and intake data on four food contaminants (aluminium 1 3-dichloro-2-propanol 3-chloro-1 2-propanediol and methylmercury). This volume and others in the WHO Food Additives Series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food government and food regulatory officers industrial testing laboratories toxicological laboratories and universities. COVER......Page 1 TITLE......Page 2 COPYRIGHT......Page 3 CONTENTS......Page 4 PREFACE......Page 6 FOOD ADDITIVES......Page 8 1. EXPLANATION......Page 10 2. BIOLOGICAL DATA......Page 11 4. COMMENTS......Page 17 5. EVALUATION......Page 18 6. REFERENCES......Page 19 1. EXPLANATION......Page 22 2. BIOLOGICAL DATA......Page 23 3. DIETARY INTAKE......Page 59 4. COMMENTS......Page 65 5. EVALUATION......Page 68 6. REFERENCES......Page 69 1. EXPLANATION......Page 78 2. BIOLOGICAL DATA......Page 79 3. DIETARY INTAKE......Page 95 4. COMMENTS......Page 101 6. REFERENCES......Page 102 1. EXPLANATION......Page 110 2. BIOLOGICAL DATA......Page 111 3. DIETARY INTAKE......Page 117 4. COMMENTS......Page 119 6. REFERENCES......Page 121 FOOD CONTAMINANTS......Page 124 ALUMINIUM FROM ALL SOURCES, INCLUDING FOOD ADDITIVES (addendum)......Page 126 1. EXPLANATION......Page 127 2. BIOLOGICAL DATA......Page 128 3. OBSERVATIONS IN HUMANS......Page 156 4. ANALYTICAL METHODS......Page 181 6. EXPOSURE TO ALUMINIUM IN THE DIET AND OTHER SOURCES......Page 182 8. DOSE–RESPONSE ANALYSIS AND ESTIMATION OF RISK OF CARCINOGENICITY/TOXICITY......Page 194 9. COMMENTS......Page 197 10. EVALUATION......Page 203 11. REFERENCES......Page 205 1,3-DICHLORO-2-PROPANOL (addendum)......Page 216 1. EXPLANATION......Page 217 2. BIOLOGICAL DATA......Page 218 3. ANALYTICAL METHODS......Page 224 4. LEVELS AND PATTERNS OF CONTAMINATION OF FOOD COMMODITIES......Page 225 5. ESTIMATED DIETARY INTAKE......Page 234 6. COMMENTS......Page 241 7. EVALUATION......Page 243 8. REFERENCES......Page 244 1. EXPLANATION......Page 246 2. BIOLOGICAL DATA......Page 248 3. ANALYTICAL METHODS......Page 250 4. LEVELS AND PATTERNS OF CONTAMINATION OF FOOD COMMODITIES......Page 251 5. ESTIMATED DIETARY INTAKE......Page 259 6. COMMENTS......Page 271 7. EVALUATION......Page 272 8. REFERENCES......Page 273 METHYLMERCURY (addendum)......Page 276 1. EXPLANATION......Page 277 2. BIOLOGICAL DATA......Page 278 3. DIETARY INTAKE......Page 298 4. COMMENTS......Page 314 5. EVALUATION......Page 316 6. REFERENCES......Page 317 ANNEXES......Page 324 ANNEX 1 REPORTS AND OTHER DOCUMENTS RESULTING FROM PREVIOUS MEETINGS OF THE JOINT FAO/WHO EXPERT COMMITTEE ON FOOD ADDITIVES......Page 326 ANNEX 2 ABBREVIATIONS USED IN THE MONOGRAPHS......Page 336 Secretariat......Page 340 ANNEX 4 TOXICOLOGICAL RECOMMENDATIONS AND INFORMATION ON SPECIFICATIONS......Page 344