Rossi’s Principles of Transfusion Medicine, Fourth Edition

Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available. It features brand new chapters on the measurement of cell kinetics, obstetric transfusion practice, cord blood, transfusion alternatives and regenerative medicine. Produced jointly with AABB, the world's leading association in the fields of blood banking and transfusion medicine, it now has two companion CD-ROMs-one containing interactive case studies and one containing PDFs of all 66 chapters. Contents......Page 6 Contributors......Page 9 Preface......Page 14 1 Transfusion in the New Millennium......Page 16 Section I. Blood Components and Derivatives......Page 30 2 Red Cell Production and Kinetics......Page 32 3 Regulation of Oxygen Delivery by Red Cells and Red Cell Substitutes......Page 44 4 Red Cell Metabolism and Preservation......Page 69 5 Red Cell Immunology and Compatibility Testing......Page 84 6 Carbohydrate Blood Groups......Page 104 7 Rh and LW Blood Group Antigens......Page 124 8 Other Protein Blood Groups......Page 136 9 Anemia and Red Blood Cell Transfusion......Page 146 10 Platelet Production, Kinetics, and Hemostasis......Page 164 11 Platelet Immunology and Alloimmunization......Page 183 12 Preparation, Preservation, and Storage of Platelet Concentrates......Page 202 13 Thrombocytopenia and Platelet Transfusion......Page 214 14 Neutrophil Production and Kinetics: Neutropenia and Neutrophilia......Page 226 15 Neutrophil Collection and Transfusion......Page 234 16 Leukocyte-Reduced Blood Components: Laboratory and Clinical Aspects......Page 243 17 Composition and Mechanisms of Blood Coagulation and Fibrinolysis......Page 262 18 Immunoglobulins......Page 275 19 Preparation of Plasma Derivatives......Page 288 20 Plasma Transfusion and Use of Albumin......Page 302 21 Applications of Cellular Radiolabeling in Transfusion Medicine......Page 313 Section II. Clinical Practice......Page 334 22 Autoimmune Hemolytic Anemia and Paroxysmal Nocturnal Hemoglobinuria......Page 336 23 Management of Immune Thrombocytopenia......Page 359 24 Bleeding from Acquired Coagulation Defects and Antithrombotic Therapy......Page 391 25 Fetal and Neonatal Hematopoiesis......Page 406 26 Obstetric Transfusion Practice......Page 421 27 Hemolytic Disease of the Fetus and Newborn......Page 433 28 Congenital Disorders of Clotting Proteins and Hypercoagulable States in Pediatrics......Page 441 29 Management of Congenital Hemolytic Anemias......Page 463 30 Blood Component Transfusions for Infants......Page 485 31 Transfusion Support for the Oncology Patient......Page 497 32 Hematopoietic Growth Factors (Cytokines)......Page 513 33 Hematopoietic Progenitor Cells: Biology and Processing......Page 523 34 Hematopoietic Progenitor Cells: Autologous Transplantation......Page 536 35 Hematopoietic Progenitor Cells: Allogeneic Transplantation......Page 557 36 Umbilical Cord Blood: A Reliable Source of Stem and Progenitor Cells for Human Transplantation......Page 574 37 Alternatives to Transfusion: Perioperative Blood Management......Page 581 38 Blood Components to Achieve Hemostasis for Surgery and Invasive Procedures......Page 590 39 Transfusion Therapy in the Care of Trauma and Burn Patients......Page 604 40 Transfusion Therapy in Solid-Organ Transplantation......Page 619 Section III. Apheresis......Page 630 41 Apheresis: Principles and Technology of Hemapheresis......Page 632 42 Therapeutic Plasma Exchange......Page 644 43 Specialized Therapeutic Hemapheresis and Phlebotomy......Page 667 Section IV. Hazards of Transfusion......Page 696 44 Overview of Hemovigilance......Page 698 45 Immunomodulatory and Proinflammatory Effects of Allogeneic Blood Transfusion......Page 714 46 Transfusion-Transmitted Hepatitis......Page 733 47 Retroviruses and Other Viruses......Page 761 48 Transfusion Transmission of Parasites......Page 775 49 Bacterial Contamination of Blood Products......Page 788 50 Prion Diseases......Page 806 51 Pathogen Inactivation......Page 816 52 Hemolytic Transfusion Reactions......Page 826 53 Febrile, Allergic, and Nonimmune Transfusion Reactions......Page 841 54 Transfusion-Associated Graft-vs-Host Disease......Page 862 55 Transfusional Iron Overload......Page 873 56 Transfusion-Related Acute Lung Injury......Page 885 Section V. Cell and Tissue Therapy......Page 900 57 HLA Antigens and Alleles......Page 902 58 Tissue Banking......Page 913 59 Adoptive Immunotherapy......Page 935 60 Gene Therapy in Transfusion Medicine......Page 951 61 Tissue Engineering and Regenerative Medicine......Page 965 Section VI. Delivery of Transfusion and Transplantation Services......Page 988 62 Recruitment and Screening of Donors and the Collection, Processing, and Testing of Blood......Page 990 63 Current Legal Issues in Transfusion Medicine......Page 1008 64 Current Good Manufacturing Practice......Page 1025 65 Transplant Organizations and Networks in the Regulation of Cellular Therapy Programs......Page 1047 66 Hospital Transfusion Committee and Quality Assurance......Page 1056 A......Page 1076 B......Page 1079 C......Page 1081 D......Page 1084 E......Page 1085 F......Page 1086 G......Page 1088 H......Page 1089 I......Page 1093 L......Page 1095 M......Page 1096 N......Page 1098 P......Page 1099 R......Page 1103 S......Page 1105 T......Page 1107 U......Page 1109 Z......Page 1110 Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available. It features brand new chapters on the measurement of cell kinetics, obstetric transfusion practice, cord blood, transfusion alternatives, regenerative medicine. Produced jointly with AABB, the world's leading association in the fields of blood banking and transfusion medicine, it now has two companion CD-ROMs - one containing interactive case studies and one containing PDFs of all 66 chapters