Role of Cancer Stem Cells in Cancer Biology and Therapy

This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark site of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective er. Read more... Content: Front Cover; Preface; Introduction; Contents; Chapter 1 Cancer Stem Cells- Fact or Fiction?; Chapter 2 Cancer Stem Cells of Sarcoma; Chapter 3 Role of Hematopoietic Stem and Progenitor Cells in the Origination of Mature B- cell Lymphomas; Chapter 4 The Leukemia Stem Cell; Chapter 5 CD44 Integrates Signaling in Stem Cell Microenvironments#; Chapter 6 The Dark Site of Conventional Cancer Therapy- Triggering the Origin of Recurrence Cancer Stem Cells; Chapter 7 Current Concepts of How to Eliminate Cancer Stem Cells Chapter 8 Novel Cancer Therapies by Molecular Targeting Distinct Growth Factor Pathways and Drug Resistance- Associated Molecules in Cancer- and Metastasis- Initiating CellsChapter 9 Salinomycin, a Candidate Drug for the Elimination of Cancer Stem Cells; Chapter 10 Targeting Breast Cancer Stem Cells; Chapter 11 Targeting Leukemic Stem Cells by Breaking Their Dormancy; Color Plate Section; Back Cover Abstract: This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark site of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective er Cancer Stem Cells : Fact Or Fiction? / Yasunari Kanda -- Cancer Stem Cells Of Sarcoma / Tomohiro Fujiwara ... [et Al.] -- Role Of Hematopoietic Stem And Progenitor Cells In The 80 Origination Of Mature B-cell Lymphomas / Jose A. Martinez-climent -- The Leukemia Stem Cell / Uri Rozovski And Zeev Estrov -- Cd44 Integrates Signaling In Stem Cell Microenvironments / Karin Williams, Premkumar Vummidi Giridhar, And Susan Kasper -- The Dark Site Of Conventional Cancer Therapy : Triggering The Origin Of Recurrence Cancer Stem Cells / Christa Nagler ... [et Al.] -- Current Concepts Of How To Eliminate Cancer Stem Cells / Elena Campos-sanchez ... [et Al.] -- Novel Cancer Therapies By Molecular Targeting Distinct Growth Factor Pathways And Drug Resistance-associated Molecules In Cancer And Metastasis-initiating Cells / Murielle Mimeault And Surinder K. Batra -- Salinomycin, A Candidate Drug For The Elimination Of Cancer Stem Cells / Cord Naujokat And Stefan Laufer -- Targeting Breast Cancer Stem Cells / Kelli E. Valdez ... [et Al.] -- Targeting Leukemic Stem Cells By Breaking Their Dormancy / Stephan Wurzer And Marieke A.g. Essers. Editors, Thomas Dittmar, Kurt S. Zänker. Includes Bibliographical References And Index. This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark side of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective eradication of CSCs