Risk Assessment In Chemical Carcinogenesis (sitzungsberichte Der Heidelberger Akademie Der Wissenschaften / Sitzungsber.heidelberg 91)

The essays in this book discuss the role that chemical agents in the environment play in the development of cancer. Thus, it gives information toimprove our understanding of carcinogenesis and how to prevent it. The essays were originally presented at an international symposium. Front Matter....Pages I-IX Risk Assessment and Management of Toxic Chemicals: The Needs and Guidelines for Developing Countries....Pages 1-6 Front Matter....Pages 7-7 Individual genetic constellations as risk factors in chemical carcinogenesis....Pages 9-16 Mechanistic Analysis as a Tool for Carcinogen Risk Assessment....Pages 17-23 Molecular Genetic Alterations such as Oncogene Activation as a Tool for the Evaluation of Risks in Chemical Carcinogenesis....Pages 24-32 Initiation and Promotion — Useful Concepts for Risk Assessment?....Pages 33-37 Front Matter....Pages 39-39 Risk Assessment of Naturally Occurring Carcinogens....Pages 41-55 Carcinogenic Drugs and their Relevance in Risk Assessment....Pages 56-63 A Weight-of-Evidence Approach to Quantitative Cancer Risk Assessment: Information Analysis....Pages 64-78 Biologically Based Pharmacokinetics and Cancer Risk Assessment....Pages 79-92 Evaluation of Epidemiologic Study Designs for the Assessment of Risk in Chemical Carcinogenesis....Pages 93-103 The role of ‘negative’ and ‘nonpositive’ studies in occupational epidemiology....Pages 104-112 Weak Associations in Occupational Epidemiology and the Criteria for Deducing Causality....Pages 113-122 Aspects of Clinical Oncology in the Assessment in Chemical Carcinogenesis....Pages 123-136 Front Matter....Pages 137-137 Provisions on carcinogenic substances in the Federal Republic of Germany and the European Community....Pages 139-148 Regulations on Chemical Carcinogens of the Environmental Protection Agency....Pages 149-159 Regulation of Chemical Carcinogenesis in Japan....Pages 160-168 Back Matter....Pages 169-172