Rho Family GTPases (Proteins and Cell Regulation Book 3)

Humans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted. The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases. The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology. "This volume provides a unique collection of detailed chapters from some of the leading research groups in the world, many of which have made key discoveries in the field. This allows for particularly insightful discussion of the current understanding of Rho function." "The key areas currently being investigated in relation to these ubiquitous proteins and described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge while ultimately bringing the subject to the level of an expert. Timely and authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology."--Jacket