Retroviruses: Strategies of Replication (Current Topics in Microbiology and Immunology, 157)

This book gives a synthesis of current knowledge on ret- rovirology. Each chapter deals with a different step in the virus life cycle, detailing the molecular aspects of virus replication. The comparison of different retroviruses exemplifies variations. Specific topics include the evolution of retrovirus genomes, integration of the provirus, viral DNA transcriptional and translational control of viral gene expression, processing of viral proteins, and packaging of virion RNA. Data on HIV and HTLV-1 are covered as well as research on animal retrovirus sys- tems. Front Matter....Pages I-XI Retrovirus Phylogeny and Evolution....Pages 1-18 Integration of Retroviral DNA....Pages 19-48 The Structure and Function of Retroviral Long Terminal Repeats....Pages 49-92 Translational Suppression in Gene Expression in Retroviruses and Retrotransposons....Pages 93-124 Retroviral RNA Packaging: Sequence Requirements and Implications....Pages 125-152 Retroviral Proteinases....Pages 153-185 Retrovirus Envelope Glycoproteins....Pages 187-253 Back Matter....Pages 255-262