Retinoid therapy : a review of clinical and laboratory research : the proceedings of an international conference held in London, 16-18 May 1983

The impact of the retinoids in clinical practice has primarily been in dermatology. When Dr Werner Bollag began his basic research and screening programme in the early 1960's, the expectation was that the retinoids would have a major impact on oncology. However, the laboratory and clinical experiences of Bollag and his colleagues in Switzerland, Stuttgen and Orfanos in Germany, led to publications on both etretinates (Tigason) and isotretinoin (Roaccutane) in the years between 1972 and 1976 in the field of dermatology. In fact the first symposium on retinoid research held in Berlin in 1981 was almost entirely dermatological. A year later a retinoid workshop in Iowa was designed to provide a forum for dermatolog­ ists from the USA involved in specific protocols investigating oral retinoids. In the UK, research into the retinoids began rather later than in Continental Europe or in the USA, although Tigason was first marketed here. It was felt in late 1982 that as many dermatologists had relatively little experience with these compounds it would be appropriate to hold an International Symposium on retinoid therapy in the UK. Thus on 16-18 May 1983 in London, 37 speakers from 11 countries addressed an audience of 300, aminly UK, dermatologists. The scientific organizing committee consisted of but two persons Dr William Cunliffe of Leeds General Infirmary, representing the European Society of Dermatolo­ gical Research, and myself from Roche Clinical Research. The Symposium was held under the auspices of the ESDR and of Roche Products Limited. Front Matter....Pages i-xvi The Development of Retinoids in Dermatology....Pages 1-7 Front Matter....Pages 9-9 Etretinate and Isotretinoin, Two Retinoids with Different Pharmacokinetic Profiles....Pages 11-23 Experience with Etretinate in the UK....Pages 25-37 The Treatment of Children with Etretinate....Pages 39-43 Austrian Experience with Etretinate....Pages 45-54 PUVA-Etretinate Therapy in Chronic Plaque and Palmar Plantar Pustular Psoriasis....Pages 55-60 The Use of Tigason (Etretinate) in Darier’s Disease....Pages 61-62 Etretinate in the Ichthyosiform Erythrodermas....Pages 63-71 Lupus Erythematosus and Etretinate....Pages 73-81 Etretinate Treatment in Erosive Lichen Planus of the Oral Mucosa....Pages 83-88 Front Matter....Pages 89-89 Overview of Mode of Action of Retinoids....Pages 91-99 Effects of Synthetic Retinoids on Human Peripheral Blood Lymphocytes and Polymorphonuclears in Vitro ....Pages 101-118 Effects of Retinoids on Chondrogenesis and Epidermogenesis In Vitro ....Pages 119-133 Further Observations on the Pharmacology of Retinoids....Pages 135-143 The Effects of Etretinate on Angiogenic Capability and Cytoxic Activity of Peripheral Blood Lymphocytes in Psoriasis....Pages 145-151 The Effect of Etretinate on Chemotactic Activity of Polymorphonuclear Leukocytes in Various Forms of Psoriasis....Pages 153-158 Front Matter....Pages 159-159 Spermatological Examinations in Males Treated with Etretinate....Pages 161-164 Effects of Oral Retinoids on Enzyme Activities of Rat Intestinal and Kidney Tubular Epithelium....Pages 165-177 Front Matter....Pages 179-179 Detection of Precancerous Bronchial Metaplasia in Heavy Smokers and its Regression after Treatment with a Retinoid....Pages 181-186 Cutaneous Neoplasia and Etretinate....Pages 187-194 Front Matter....Pages 179-179 Cutaneous Neoplasia and the Retinoids....Pages 195-199 Front Matter....Pages 201-201 A Dose Response Study of 13- cis -Retinoic Acid Therapy in Cystic Acne....Pages 203-213 Isotretinoin in the Treatment of Acne....Pages 215-221 The Overall USA Experience of Retinoids in Acne....Pages 223-228 Front Matter....Pages 229-229 Relapse Rate of Acne Conglobata after Stopping Isotretinoin....Pages 231-239 A Follow-up Study of 13- cis -Retinoic Acid Therapy in Cystic Acne....Pages 241-251 Front Matter....Pages 253-253 13- cis -Retinoic Acid in Acne — Mechanism of Action....Pages 255-266 Effect of 13- cis -Retinoic Acid and Cyproterone Acetate on Acne Severity, Sebum Excretion Rate, Dermal and Epidermal Lipogenesis, Serum Lipids and Liver Function Tests....Pages 267-275 Isotretinoin and Oral Contraceptive Steroids....Pages 277-283 Front Matter....Pages 285-285 Comparison of Isotretinoin and Cyproterone Acetate — a Clinical and Laboratory Study....Pages 287-292 A Comparative Study of 13- cis -Retinoic Acid and Erythromycin Therapy in Severe Acne....Pages 293-301 Use of Isotretinoin in Severe Cases with Papular Pustular Acne....Pages 303-311 Front Matter....Pages 313-313 The Use of Isotretinoin in Rosacea....Pages 315-319 Use of Isotretinoin in the Ichthyoses....Pages 321-325 Front Matter....Pages 327-327 Response of Psoriatic Arthropathy to Arotinoid (Ro 13-6298): A Pilot Study....Pages 329-333 Anti-Inflammatory Effects of the Retinoids....Pages 335-343 No Influence of Three Synthetic Retinoids (Ro 10-1670, Ro 4-3780. Ro 13-6298) on Lipoxygenase Activity in Two in Vitro Systems....Pages 345-347 The Management of Cystic, Conglobate and Severe Acne Irresponsive to Systemic Antibiotics with Roaccutane....Pages 349-364 Back Matter....Pages 365-369