Retinal Pigment Epithelium and Macular Diseases (Documenta Ophthalmologica Proceedings Series, 62)

This volume of Documenta Ophthalmologica Proceedings Series collects the scientific papers presented at the 2nd International Symposium on Retinal Pigment Epithelium and the 4th Meeting of the European Macula Group held in Genoa, May 29-June 1, 1996. The Symposium on Retinal Pigment Epithelium was promoted by the University Eye Clinic of Genoa as the natural continuation of the first Symposium held with great success in Genoa in 1988. The previous Meetings of the European Macula Group were held in Coimbra (1988), Crete (1989) and Athens (1994). I was greatly pleased and honoured to host the fourth congress of this distinguished Society and I am grateful to Gabriel Coscas, Jose Cunha-Vaz and George Theodossiadis, found­ ers of the Society, for selecting Genoa on this occasion. The two meetings integrated well in an unicuum and brought together an exceptional number of outstanding retinal specialists coming from all over the world. All the aspects of the current research concerning retinal pigment epithelial and macular diseases were covered. Several interesting presentations regarded new techniques of retinal and choroidal imaging. A full session was dedicated to the latest advances in culture and transplantation of retinal pigment epithelial cells. Age-related macular degeneration was a major subject for discussion, including new approaches to treatment. This topic was high­ lighted by a mini-symposium on drusen, including a series of superb lectures on classification, clinicopathological studies, indocyanine green imaging, and laser treatment for prevention of choroidal neovascularization. Front Matter....Pages i-xv A short history of the retinal pigment epithelium....Pages 1-4 Blood—retinal barrier and new perspectives of management of retinal disease....Pages 5-11 Subretinal protein and serous detachment....Pages 13-17 Ageing of the human retinal pigment epithelium....Pages 19-28 Sub-RPE deposits might be related to defective ubiquitin-dependent proteolysis....Pages 29-30 Selective damage on retinal pigment epithelium causes photoreceptor cell death by apoptosis....Pages 31-36 RPE lipofuscin in ageing and age-related macular degeneration....Pages 37-45 Antioxidant functions of glutathione in human retinal pigment epithelium in relation to age-related macular degeneration....Pages 47-57 Electrical activity of retinal pigment epithelium evaluated by EOG and c-wave....Pages 59-62 c-wave of ERG in carriers of Leber congenital amaurosis....Pages 63-67 Congenital and acquired lesions of the retinal pigment epithelium....Pages 69-80 The effects of UV-A light in indirect irradiation on cultures of bovine lens epithelium....Pages 81-88 Localization of bFGF in wound healing process of RPE cell in vitro ....Pages 89-93 Promotion of retinal pigment epithelial cell proliferation in experimental choroidal neovascularization by human interferon-beta....Pages 95-100 Local administration of interferon-beta promotes proliferation of retinal pigment epithelial cells in repairing process after laser photocoagulation....Pages 101-105 Transdifferentiation of cultured retinal pigment epithelial cells....Pages 107-123 Retinal pigment epithelial transplantation in exudative age-related macular degeneration: what do in vivo and in vitro studies teach us?....Pages 125-134 Experimental transplantation of human retinal pigment epithelial cells on collagen substrates....Pages 135-141 Preinjection fluorescence in indocyanine green angiography....Pages 143-147 Infrared light imaging in retinal diseases. A comparison with fluorescein angiography and ophthalmoscopy....Pages 149-150 Infrared imaging of choroidal neovascularization by scanning laser ophthalmoscope....Pages 151-152 Macular syndromes following cataract surgery: intraoperative and serial postoperative fluorescein angiographic findings....Pages 153-156 Treatment of macular holes with argon laser evaluated by scanning laser tomography....Pages 157-159 Three-dimensional ultrasonography in the evaluation of pathological myopia....Pages 161-164 The macular choroid and its developments at the embryological stage....Pages 165-170 The indocyanine green videoangiography in hypertensive choroidopathy....Pages 171-172 The expanding clinical spectrum of idiopathic polypoidal choroidal vasculopathy (IPCV)....Pages 173-183 ICG angiographic evaluation of choroidal abnormalities associated with multifocal choroidopathies....Pages 185-191 Vogt—Koyanagi—Harada-type disease: a case report....Pages 193-197 Indocyanine green angiographic findings in a case of Harada’s disease....Pages 199-202 Indocyanine green angiography in choroidal osteoma....Pages 203-204 Indocyanine green angiography of choroidal naevi and suspected melanomas....Pages 205-207 An anomalous case of angioid streaks and multiple and recurrent detachments of retinal pigment epithelium....Pages 209-218 Conservative treatment of choroidal melanomas of the posterior pole....Pages 219-220 Assessment of the sympatho-vagal interaction in central serous chorioretinopathy measured by power spectral analysis of heart rate variability....Pages 221-224 Central serous chorioretinopathy: an endocrine screening....Pages 225-232 Digital indocyanine green angiography of central serous chorioretinopathy....Pages 233-236 Indocyanine green angiography: utility in chronic central serous chorioretinopathy....Pages 237-241 Indocyanine green angiography in central serous chorioretinopathy....Pages 243-246 Follow-up evaluation of indocyanine green angiographic findings in central serous chorioretinopathy....Pages 247-251 Long-term follow-up in patients with chronic central serous chorioretinopathy....Pages 253-254 Indocyanine green angiography in multifocal posterior pigment epitheliopathy....Pages 255-262 Idiopathic serous pigment epithelium detachment and indocyanine green angiography....Pages 263-267 Propranolol and nimodipine in the treatment of acute and chronic central serous choroidopathy....Pages 269-273 Photic maculopathy in a patient under treatment with clomipramine and bright light therapy....Pages 275-278 Dexamethasone treatment for solar retinopathy:long-term follow-up....Pages 279-283 Subretinal fibrosis in Stargardt’s disease....Pages 285-290 Age-related geographic atrophy and pattern dystrophy of the RPE....Pages 291-296 Bilateral ocular toxoplasmosis: a clinical case....Pages 297-299 Indocyanine green angiography of drusen....Pages 301-302 A clinicopathological study of drusen types....Pages 303-305 Histopathological features of drusen and age-related macular degeneration....Pages 307-322 Choroidal neovascularization prevention trial....Pages 323-324 The one-year result of a prospective, randomized study of laser photocoagulation of eyes with soft drusen in early age-related maculopathy....Pages 325-327 ICG drusen-like alterations in the course of age-related macular degeneration....Pages 329-333 Electrophysiological and neurophysiological symptoms of age-related macular dystrophy....Pages 335-339 Watershed filling in age-related macular degeneration: the implications of panretinal photocoagulation....Pages 341-342 Isolated occult choroidal neovascularization: comparison between early and late phases of ICG angiography....Pages 343-346 Indocyanine green angiography in age-related macular degeneration with fluorescein angiography occult neovascularization....Pages 347-353 Defined and occult choroidal neovessels in age-related macular degeneration by means of a scanning laser ophthalmoscope: a retrospective study of 100 cases....Pages 355-359 Indocyanine green angiography follow-up of plaque choroidal neovascularization in age-related macular degeneration....Pages 361-364 Detection of recurrent choroidal neovascularization in age-related macular degeneration: comparison of clinical examination, fluorescein angiography and indocyanine green videoangiography....Pages 365-370 Massive subretinal haemorrhage in age-related macular degeneration....Pages 371-375 Choroidal neovascular membrane in age-related macular degeneration, histopathological and clinical correlation....Pages 377-378 Indocyanine green angiography-guided laser photocoagulation of choroidal neovascularization in age-related macular degeneration....Pages 379-381 Photocoagulation of choroidal neovascular membrane (CNV) with diode laser (805 nm)....Pages 383-385 Radiation therapy for age-related subfoveal neovascular membranes....Pages 387-392 The disc-to-macula circulation time in diabetic retinopathy....Pages 393-395 Non-proliferative diabetic retinopathy — new findings in indocyanine green angiography....Pages 397-399 The use of pentoxifylline (Trental) in diabetic retinopathy....Pages 401-403 Laser treatment of diabetic cystoid macular oedema with a grid extended to the foveal avascular zone....Pages 405-411 Idiopathic retinal occlusive vasculitis and the macula....Pages 413-420 Macroaneurysms secondary to branch retinal vein occlusion....Pages 421-426 Decrease of PKC activity by a peptide fraction from porcine factor VIII in endothelial cells CPA-47....Pages 427-430 Clinical, angiographic and histopathological results after surgical removal of subfoveal choroidal new vessels....Pages 431-433 Subfoveal choroidal neovascularization in punctate inner choroidopathy: surgical management and pathological findings....Pages 435-437 Vitrectomy in Coats’ disease....Pages 439-445 Automated perimetry variations found on epiretinal macular membranes....Pages 447-452 Relaxing retinotomies: visual results and macular findings....Pages 453-454 Back Matter....Pages 455-462 This book contains the papers presented at the 2nd International Symposium on Retinal Pigment Epithelium and at the 4th Meeting of the European Macula Group. The following topics are covered: functions of RPE and Bruch's membrane; RPE cells proliferation and transplantation; fundus imaging; choroidal disorders; central serous chorioretinopathy and other maculopathies; age-related macular degeneration; choroidal neovascularization; diabetes and retinal vascular disorders; macular surgery. In this book, all those interested in retinal diseases can find the latest findings of clinical and laboratory research, presented by the most prominent experts in the field