Restless Legs Syndrome: Diagnosis and Treatment (Neurological Disease and Therapy)

A guide on RLS, this title examines the pathogenesis, diagnosis, and treatment of a condition affecting nearly 10 per cent of the population. Ranging from basic science to therapeutics, it analyzes the many emerging medications impacting the management of this disorder and strives to address the explosion of research in the field. The most authoritative and comprehensive guide on RLS to date, this expertly written source examines the pathogenesis, diagnosis, and treatment of a condition affecting nearly 10% of the population. Ranging from basic science to therapeutics, Restless Legs Syndrome analyzes the many new and emerging medications impacting the management of this disorder and strives to address the explosion of research in the field Section I: Basic Science: Overview Of Sleep / Allison V. Chan And Clete A. Kushida -- The Brain's Dopamine Systems And Their Relevance To Restless Legs Syndrome / Alon A. Freeman And David B. Rye -- Circadian Physiology / Mauro Manconi And Luigi Ferini-strambi -- Systemic Iron Regulation / John Beard -- The Physiology Of Restless Legs Syndrome / Stephany Fulda And Thomas-christian Wetter -- Progress In The Animal Models Of Restless Legs Syndrome / Weidong Le, Hongru Zhao, And William G. Ondo -- Pathology Of Restless Legs Syndrome / James R. Connor And Xinsheng Wang -- Genetics Of Restless Legs Syndrome / Shaoqi Rao, Juliane Winkelman, And Qing K. Wang -- Section Ii: Clinical Diagnosis: Consequences Of Sleep Deprivation / Li Ling Lim And Nancy Foldvary-schaefer -- History Of Restless Leg Syndrome / Wayne A. Hening -- Restless Leg Syndrome: Diagnostic Criteria And Differential Diagnosis / Shahul Hameed And E.k. Tan --^ Occurrence Of Restless Leg Syndrome / Jan Ulfberg And Bjorn Bjorvatn -- Childhood-onset Restless Leg Syndrome / Suresh Kotagal And Michael H. Silber -- Periodic Limb Movements And Periodic Limb Movement Disorder / Margaret Park And Cynthia L. Comella -- Restless Legs Syndrome Effects On Quality Of Life / Richard P. Allen -- Restless Legs Syndrome: Personal Perspectives / Georgiana Bell -- Section Iii: Secondary Restless Legs Syndrome: Iron Deficiency-associated Restless Legs Syndrome / William G. Ondo -- Restless Legs Syndrome And Renal Failure / Kai Ming Chow And David Shu Cheong Hui -- Restless Legs Syndrome And Neuropathy/myelopathy / Birgit Hogl And Werner Poewe -- Restless Legs Syndrome In Pregnancy / Luigi Ferini-strambi And Mauro Manconi -- Restless Legs Syndrome And Parkinson's Disease / Vandana Dhawan And K. Ray Chaudhuri -- Iatrogenic Restless Legs Syndrome / Changkook Yang And John W. Winkelman --^ Other Restless Legs Syndrome Associations / Irfan Lalani And William G. Ondo -- Section Iv: Treatment Of Restless Legs Syndrome: Treatment Overview / William G. Ondo -- Dopaminergic Therapy For Restless Legs Syndrome / Philip M. Becker -- Dopaminergic Augmentation / Diego Garcia-borreguero, Oscar Larrosa, Renata Egatz, Belen Cabrero, And Patrick Troster -- Opioids And The Restless Legs Syndrome: Treatment And Pathogenic Considerations / Arthur S. Walters -- Iron Therapy For Restless Legs Syndrome / Charlene E. Gamaldo And Christopher J. Earley -- Other Therapies In Restless Legs Syndrome / Joohi Shahed And William G. Ondo -- Section V: Future Directions In Restless Legs Syndrome: Future Directions. Edited By William G. Ondo. Includes Bibliographical References And Index. Front cover......Page 1 Title Page......Page 8 ISBN 0849336147......Page 9 Preface......Page 12 2. The Brain’s Dopamine Systems and Their Relevance to Restless Legs Syndrome......Page 14 6. Progress in the Animal Models of Restless Legs Syndrome......Page 15 10. History of Restless Legs Syndrome......Page 16 14. Periodic Limb Movements and Periodic Limb Movement Disorder......Page 17 Section III: Secondary Restless Legs Syndrome......Page 18 22. Iatrogenic Restless Legs Syndrome......Page 19 25. Dopaminergic Therapy for Restless Legs Syndrome......Page 20 28. Iron Therapy in Restless Legs Syndrome......Page 21 30. Future Directions......Page 22 Contributors......Page 24 30. Future Directions......Page 0 A......Page 378 B,C......Page 379 E......Page 380 H......Page 381 I......Page 382 N......Page 383 P......Page 384 Q,R......Page 386 S......Page 388 U,V,W,Z......Page 389 FIGURE 7.1 The pictures represent the immunostaining patterns of the human substantia nigra in control brains (left panels) and restless leg syndrome (RLS) brains (right panels).......Page 390 Back cover......Page 392 Overview of Sleep. The Brain's Dopamine Systems. Circadian Physiology. Systemic Iron Regulation. The Physiology of RLS. Progress in the Animal Modeling of RLS. Pathology of RLS. Genetics of RLS. Consequences of Sleep Deprivation. Diagnostic Criteria and Differential Diagnosis. Occurrence of RLS. Childhood-Onset RLS. Periodic Limb Movement of Sleep. Quality of Life in RLS. Patient Perspectives. Iron Deficiency-Associated RLS. Renal Failure. Neuropathy/Myelopathy. Pregnancy. Parkinson's Disease. Iatrogenic RLS. Other RLS Associations. Treatment Overview. Dopaminergic Treat