Respiratory System Diseases (Advances in Experimental Medicine and Biology Book 980)

"Both communicable and noncommunicable diseases of the respiratory system are an increasing healthcare problem despite medical advances. This book aims at unraveling the mechanisms and improving the treatment of pulmonary pathologies, ranging from such common conditions like influenza and related viral infections, functional lung dysfunction, to lung lesions and others. Chapters present late-breaking findings in the diagnostics, pharmacotherapy, and clinical evidence-based decision-making to provide results that can be used to improve healthcare and quality of life. Extending new knowledge and exploring recent medical advances, the book will hopefully help enrich research and clinical experience regarding important respiratory issues. The book is intended for general practitioners and all professionals engaged in the pulmonary field, from basic scientists to clinical investigators"--Publisher's description Preface 6 Contents 8 Impaired Vascular Function in Sarcoidosis Patients 10 1 Introduction 11 2 Methods 11 2.1 Patients 11 2.2 Angiological Examinations 11 2.3 Blood Tests 12 2.4 Statistical Analysis 12 3 Results 12 4 Discussion 15 References 17 Effectiveness of Bronchofiberoscopy in Diagnosis of Lung Lesions 19 1 Introduction 20 2 Methods 20 3 Results 21 4 Discussion 22 5 Conclusions 23 References 24 Hospital Morbidity Database for Epidemiological Studies on Churg-Strauss Syndrome 26 1 Introduction 27 1.1 Incidence of EGPA 27 1.2 Hospital Morbidity Database for Epidemiological Studies 27 1.3 Study Aims 28 2 Methods 28 2.1 Statistical Analysis 29 3 Results 29 4 Discussion 29 5 Conclusions 31 References 31 Public Perception of the Risks Associated with Infectious Diseases in Poland: Ebola and Influenza and Their Impact on the Atti... 33 1 Introduction 34 2 Methods 35 2.1 Study Population 35 2.2 Measures 35 2.3 Data Analysis 36 3 Results 36 3.1 Ebola Assessment 36 3.2 Influenza Assessment 37 4 Discussion 38 5 Conclusions 40 References 41 The Sentinel System as the Main Influenza Surveillance Tool 43 1 Introduction 44 2 Methods 45 2.1 Material 45 2.2 Isolation of RNA 45 2.3 Real-Time Reverse Transcription Polymerase Chain Reaction (rRT-PCR) 45 2.4 Conventional Multiplex RT-PCR 45 3 Results 45 4 Discussion 46 References 49 The Activity of Influenza and Influenza-like Viruses in Individuals Aged over 14 in the 2015/2016 Influenza Season in Poland 50 1 Introduction 51 2 Methods 51 2.1 Collection of Specimens 51 2.2 Isolation of RNA 51 2.3 Reverse Transcription Polymerase Chain Reaction (RT-PCR) 52 2.4 Real-Time PCR (qRT-PCR) 52 2.5 Conventional Multiplex RT-PCR 52 3 Results 52 4 Discussion 54 References 55 Clinical Utility of Berlin Questionnaire in Comparison to Polysomnography in Patients with Obstructive Sleep Apnea 56 1 Introduction 57 2 Methods 57 2.1 Study Population 57 2.2 Assessment of Obstructive Sleep Apnea 57 2.3 Assessment of Covariates 58 2.4 Statistical Analysis 58 3 Results 58 4 Discussion 59 References 61 Isolated Hearing Impairment Caused by SPATA5 Mutations in a Family with Variable Phenotypic Expression 63 1 Introduction 64 2 Cinical Report 64 3 Discussion 67 References 69 Stress Response, Brain Noradrenergic System and Cognition 71 1 Noradrenergic Circuitry 72 2 Stress Response 72 3 Prefrontal Cortex 74 4 Conclusions 75 References 76 Small Airway Obstruction in Chronic Obstructive Pulmonary Disease: Potential Parameters for Early Detection 79 1 Introduction 80 2 Methods 80 2.1 Patients 80 2.2 Respiratory Spirometry and Oscillometry 81 2.3 Statistical Elaboration 81 3 Results 82 4 Discussion 82 5 Conclusions 85 References 85 Index 87 Front Matter....Pages i-viii Impaired Vascular Function in Sarcoidosis Patients....Pages 1-9 Effectiveness of Bronchofiberoscopy in Diagnosis of Lung Lesions....Pages 11-17 Hospital Morbidity Database for Epidemiological Studies on Churg-Strauss Syndrome....Pages 19-25 Public Perception of the Risks Associated with Infectious Diseases in Poland: Ebola and Influenza and Their Impact on the Attitude to Vaccination....Pages 27-36 The Sentinel System as the Main Influenza Surveillance Tool....Pages 37-43 The Activity of Influenza and Influenza-like Viruses in Individuals Aged over 14 in the 2015/2016 Influenza Season in Poland....Pages 45-50 Clinical Utility of Berlin Questionnaire in Comparison to Polysomnography in Patients with Obstructive Sleep Apnea....Pages 51-57 Isolated Hearing Impairment Caused by SPATA5 Mutations in a Family with Variable Phenotypic Expression....Pages 59-66 Stress Response, Brain Noradrenergic System and Cognition....Pages 67-74 Small Airway Obstruction in Chronic Obstructive Pulmonary Disease: Potential Parameters for Early Detection....Pages 75-82 Back Matter....Pages 83-84