Resistance to Targeted Therapies Against Adult Brain Cancers

This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies. Front Matter....Pages i-xvi Targeted Therapies in Brain Tumours: An Overview....Pages 1-23 Targeting Chemotherapy Resistance in Glioblastoma Through Modulation of ABC Transporters....Pages 25-54 Resistance of Glioblastomas to Radiation Therapy....Pages 55-68 The Blood-Brain Barrier in Glioblastoma: Pathology and Therapeutic Implications....Pages 69-87 Resistance of Brain Tumours to Small-Molecule-Targeted Therapies: Lessons from Various Cancer Types....Pages 89-105 Drug Repurposing to Circumvent Chemotherapy Resistance in Brain Tumours....Pages 107-144 Small-Molecule Inhibitors in Glioblastoma: Key Pathways and Resistance Mechanisms....Pages 145-174 Imaging Targeted Therapy Response and Resistance in Glioblastoma....Pages 175-198 Drug Resistance in Malignant Meningiomas....Pages 199-217 Recurrence of Low-Grade Glioma: Have the Targeted Therapies Improved for Better Outcomes?....Pages 219-235 Host–Tumor Interactions in Brain Cancer Metastasis Leading to Drug Resistance....Pages 237-253 Back Matter....Pages 255-260