Reoviruses I: Structure, Proteins, and Genetics (Current Topics in Microbiology and Immunology (233/1))

Reoviruses are one of the most important viral groups for understanding the molecular and genetic basis for viral pathogenesis. These two volumes cover virtually all aspects of reovirus biology. Volume I begins with a review of reovirus structure; further chapters deal with functions of the reovirus structural proteins, the assembly of the genome, and reovirus mutants. Volume II reviews general mechanisms of reovirus persistent infection and cytopathic effects, and then discusses reovirus-induced disease in specific organ systems including the heart, nervous and endocrine systems, liver and biliary system, and intestine. Together, these two volumes provide a current and comprehensive review of the mammalian reoviruses. Front Matter....Pages I-XVII Structure of Mammalian Orthoreovirus Particles....Pages 1-30 Enzymatic and Control Functions of Reovirus Structural Proteins....Pages 31-56 Assembly of the Reovirus Genome....Pages 57-68 Temperature-Sensitive Mutants of Reovirus....Pages 69-107 Suppression and Reversion of Mutant Phenotype in Reovirus....Pages 109-135 Reovirus Cell Attachment Protein σ1: Structure-Function Relationships and Biogenesis....Pages 137-153 Signal Transduction and Antiproliferative Function of the Mammalian Receptor for Type 3 Reovirus....Pages 155-166 Reovirus Capsid Proteins σ3 and μ1: Interactions That Influence Viral Entry, Assembly, and Translational Control....Pages 167-183 Reovirus σ3 Protein: dsRNA Binding and Inhibition of RNA-Activated Protein Kinase....Pages 185-196 Reovirus M1 Gene Expression....Pages 197-213 Back Matter....Pages 215-226 A study of reoviruses. Topics covered include: the structure of mammalian orthoreovirus particles; assembly of the reovirus genome; reovirus cell attachment protein sigma1; reovirus capsid protein sigma3 and my1; reovirus sigma3 protein - dsRNA M1 gene expression.