Regulation of Sertoli Cell and Germ Cell Differentiation (Advances in Anatomy, Embryology and Cell Biology Book 181)

The Intention Of The Present Monograph Is To Shed More Light On The Regulation Of Sertoli Cell And Germ Cell Differentiation. Involving Knockout And Transgenic Mouse Models, The Authors Focus On Male Factor Infertility That Might Be Related To Altered Maturation Of Sertoli Cells, Male Factor Infertility That Might Be Due To Incorrect Histone-to-protamine Exchange In Haploid Spermatids, And Progression Of Testicular Germ Cell Cancer That Might Be Favoured By An Aberrant Sertoli Cell Germ Cell Communication. Spermatogenesis / K. Steger -- The Sertoli Cell / R. Brehm -- The Differentiation Of Male Germ Cells / K. Steger -- Idiopathic Male Infertility: Impaired Histone-to-protamine Exchange? / K. Steger -- Carcinoma In Situ Of The Testis And Testicular Germ Cell Tumour: Impaired Intercellular Communication Due To Altered Sertoli Cell Differentiation? / R. Brehm. R. Brehm, K. Steger. Includes Bibliographical References (pages [71]-93) And Index. Mode Of Access: World Wide Web. Cover Page......Page 1 Series Title......Page 2 Inside Cover......Page 3 Copyright......Page 4 Preface......Page 5 Acknowledgements......Page 7 List of Contents......Page 8 1.1 Organization of the Seminiferous Epithelium......Page 10 1.3 Regulation of Spermatogenesis......Page 11 2.1 Origin and Maturation of the Sertoli Cell......Page 16 2.2 Altered Sertoli Cell Differentiation in Testicular Disorders......Page 20 2.3 Differentiation Markers of the Sertoli Cell......Page 24 2.4 Sertoli Cell Intercellular Communication......Page 29 2.5 Knockout and Transgenic Mouse Models and Mutations in Man......Page 36 2.7 Vimentin Mutants......Page 39 2.8 p27Kip1 Mutants......Page 40 2.9 Androgen Receptor Mutants......Page 41 2.11 Connexin Mutants......Page 43 3.1 The Regulation of Gene Expression During Prespermatogenesis......Page 45 3.2 The Regulation of Gene Expression During Spermatogenesis......Page 47 4 Idiopathic Male Infertility: Impaired Histone-to-Protamine Exchange?......Page 54 4.2 Male Infertility Caused by Incorrect Translational Regulation......Page 56 4.3 Male Infertility Caused by Incorrect Chromatin Condensation......Page 57 5.1 Carcinoma In Situ of the Testis and Testicular Germ Cell Tumour......Page 58 5.2 Sertoli Cell Differentiation in Seminiferous Tubules Infiltrated with Carcinoma In Situ of the Testis......Page 63 5.3 Role of Gap Junctional Intercellular Communication in Carcinogenesis......Page 71 5.4 Role of Gap Junctional Intercellular Communication in the Development of Carcinoma In Situ of the Testis to Testicular Germ Cell Tumour......Page 74 References......Page 80 Subject Index......Page 103 Unwanted childlessness affects approximately one in six couples worldwide. - though the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization (WHO), in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. Based on these ?gures, the - cidence of male factor infertility in the general population is approximately 7%. The majority of these men, approximately 30%, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer, which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression, and tumour progression may be favoured by an aberrant Sertoli cell-germ cell communication. Describes the regulation of Sertoli cell and germ cell differentiation. Involving knockout and transgenic mouse models, the authors focus on male factor infertility that might be related to altered maturation of Sertoli cells, male factor infertility that might be due to incorrect histone-to-protamine exchange in haploid spermatids, and more