Regulation of microRNAs (Advances in Experimental Medicine and Biology, 700)

Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book. Microrna Biogenesis And Function : An Overview / Rene F. Ketting -- Regulation Of Pri-mirna Processing Through Smads / Akiko Hata And Brandi N. Davis -- Stimulation Of Pri-mir-18a Processing By Hnrnp A1 / Gracjan Michlewski, Sonia Guil, And Javier F. Cáceres -- Ksrp Promotes The Maturation Of A Group Of Mirna Precursors / Michele Trabucchi ... [et Al.] -- Hormonal Repression Of Mirna Biosynthesis Through A Nuclear Steroid Hormone Receptor / Sally Fujiyama-nakamura, Kaoru Yamagata, And Shigeaki Kato -- Autoregulatory Mechanisms Controlling The Microprocessor / Robinson Triboulet And Richard I. Gregory -- Regulation Of Pre-mirna Processing / Nicolas J. Lehrbach And Eric A. Miska -- The Effect Of Rna Editing And Adars On Mirna Biogenesis And Function / Bret S.e. Heale, Liam P. Keegan, And Mary A. O'connell -- Mirnas Need A Trim Regulation Of Mirna Activity By Trim-nhl Proteins / F. Gregory Wulczyn ... [et Al.]. Properties Of The Regulatory Rna-binding Protein Hur And Its Role In Controlling Mirna Repression / Nicole-claudia Meisner And Witold Filipowicz -- Turnover Of Mature Mirnas And Sirnas In Plants And Algae / Heriberto Cerutti And Fadia Ibrahim -- Micrornases And The Regulated Degradation Of Mature Animal Mirnas / Helge Grobhans And Saibal Chatterjee. Edited By Helge Grosshans. Includes Bibliographical References And Index. Front Matter....Pages i-xvi microRNA Biogenesis and Function....Pages 1-14 Regulation of pri-miRNA Processing Through Smads....Pages 15-27 Stimulation of pri-miR-18a Processing by hnRNP A1....Pages 28-35 KSRP Promotes the Maturation of a Group of miRNA Precuresors....Pages 36-42 Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor....Pages 43-55 Autoregulatory Mechanisms Controlling the Microprocessor....Pages 56-66 Regulation of pre-miRNA Processing....Pages 67-75 The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function....Pages 76-84 miRNAs Need a Trim....Pages 85-105 Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression....Pages 106-123 Turnover of Mature miRNAs and siRNAs in Plants and Algae....Pages 124-139 MicroRNases and the Regulated Degradation of Mature Animal miRNAs....Pages 140-155 Back Matter....Pages 157-161