Regional Opioid Analgesia: Physiopharmacological Basis, Drugs, Equipment And Clinical Application (developments In Critical Care Medicine And Anaesthesiology) (volume 20)

by E.K. ZSIGMOND, M.D. Department of Anesthesiology University of Illinois Chicago U.S.A. It is, indeed, a distinct honor and privilege to be invited by the authors to write a preface to this monumental monograph, Regional Opioid Analgesia. Regional Opioid Analgesia is a colossal undertaking by Drs. De Castro, Meynadier and Zenz shortly after the introduction of this revolutionary approach to pain relief which opened a new epoch in analgesiology. This is, indeed, the first authentic and comprehensive textbook encompassing the current knowl­ edge on this novel approach to pain relief. We are indebted to the authors for introducing the new opioids to regional analgesia with the scientists, who de­ veloped the potent short and ultrashort acting opioids with high therapeutic indices, which many researchers dreamt about but never before materialized. The side effect liabilities of these new opioids are minute as compared to morphine and meperidine. Regional Opioid Analgesia could not have been more authentically written than by Drs. De Castro,Zenz and Meynadier,who have conducted daily clinical investigations on all known opioids for regional analgesia as well as for neurolept analgesia. Therein lies the great value of this monograph: it is the most authentic work on this topic. By E.K. ZSIGMOND, M.D. Department of Anesthesiology University of Illinois Chicago U.S.A. It is, indeed, a distinct honor and privilege to be invited by the authors to write a preface to this monumental monograph, Regional Opioid Analgesia. Regional Opioid Analgesia is a colossal undertaking by Drs. De Castro, Meynadier and Zenz shortly after the introduction of this revolutionary approach to pain relief which opened a new epoch in analgesiology. This is, indeed, the first authentic and comprehensive textbook encompassing the current knowl edge on this novel approach to pain relief. We are indebted to the authors for introducing the new opioids to regional analgesia with the scientists, who de veloped the potent short and ultrashort acting opioids with high therapeutic indices, which many researchers dreamt about but never before materialized. The side effect liabilities of these new opioids are minute as compared to morphine and meperidine. Regional Opioid Analgesia could not have been more authentically written than by Drs. De Castro, Zenz and Meynadier, who have conducted daily clinical investigations on all known opioids for regional analgesia as well as for neurolept analgesia. Therein lies the great value of this monograph: it is the most authentic work on this topic Front Matter....Pages i-xxi Introduction....Pages 1-7 Front Matter....Pages 9-9 Developments, advantages and drawbacks of regional opioid analgesia....Pages 11-18 Anatomy and physiology....Pages 19-33 Micropharmacology of antinociceptive substances in the spinal cord....Pages 35-49 Pharmacokinetics of opioids....Pages 51-83 Pharmacodynamics of opioids....Pages 85-94 Side effects....Pages 95-130 Drugs....Pages 131-209 Equipment and drug delivery systems....Pages 211-267 Front Matter....Pages 269-269 Clinical applications, generalities....Pages 271-272 Intraoperative use....Pages 273-284 Postoperative pain....Pages 285-328 Other applications in acute pain situations....Pages 329-335 Obstetrics....Pages 337-362 Cancer pain....Pages 363-423 Chronic non-malignant pain....Pages 425-431 Perineural opioid analgesia (PNOA)....Pages 433-435 Comparative evaluation of the risk/benefit ratio....Pages 437-447 Future directions in spinal opioid research and conclusions....Pages 449-451 What is regional opioid analgesia?....Pages 453-456 Front Matter....Pages 269-269 Technical data of equipment for spinal opioid therapy....Pages 457-508 Back Matter....Pages 509-637