Reflections on a Century of Malaria Biochemistry (Volume 67) (Advances in Parasitology, Volume 67)

Malaria is one of the most common infectious diseases and an enormous public health problem. Each year it causes disease in approximately 650 million people and kills between one and three million, most of them young children in Sub-Saharan Africa. This book provides an overview of the research that has been done in malaria biochemistry in the quest to find a cure. It discusses how our understanding has helped us to develop better diagnostics and novel chemotherapies. Researchers will find having all of this information in one volume, annotated with personal reflections from a leader in the field, invaluable given the big push being made on various fronts to use the latest drug discovery tools to attack malaria and other developing country diseases. * Reviews the past 100 years of malaria biochemistry research providing researchers with an overview of the investigations that have been undertaken in this field Benefit: Allows researchers to see what progress has been made so that they can use this knowledge when trying to develop the latest drug discovery tools to attack malaria * Chronicles both biochemical successes and failures Benefit: Allows researchers to see what has and hasn't work which they can then apply in their own research Content: Series Editors Page ii Copyright page Page iv Chapter 1 Introduction Review Article Page 1 Irwin W. Sherman Chapter 2 An Introduction to Malaria Parasites Review Article Pages 3-7 Irwin W. Sherman Chapter 3 The Early Years Review Article Pages 9-13 Irwin W. Sherman Chapter 4 Show Me the Money Review Article Pages 15-24 Irwin W. Sherman Chapter 5 In Vivo and In Vitro Models Review Article Pages 25-47 Irwin W. Sherman Chapter 6 Malaria Pigment Review Article Pages 49-57 Irwin W. Sherman Chapter 7 Chloroquine and Hemozoin Review Article Pages 59-61 Irwin W. Sherman Chapter 8 Isoenzymes Review Article Pages 63-71 Irwin W. Sherman Chapter 9 The Road to the Plasmodium falciparum Genome Review Article Pages 73-85 Irwin W. Sherman Chapter 10 Carbohydrate Metabolism Review Article Pages 87-93 Irwin W. Sherman Chapter 11 Pyrimidines and the Mitochondrion Review Article Pages 95-100 Irwin W. Sherman Chapter 12 The Road to Atovaquone Review Article Pages 101-104 Irwin W. Sherman Chapter 13 The Ring Road to the Apicoplast Review Article Pages 105-110 Irwin W. Sherman Chapter 14 Ribosomes and Ribosomal Ribonucleic Acid Synthesis Review Article Pages 111-115 Irwin W. Sherman Chapter 15 De Novo Synthesis of Pyrimidines and Folates Review Article Pages 117-138 Irwin W. Sherman Chapter 16 Salvage of Purines Review Article Pages 139-145 Irwin W. Sherman Chapter 17 Polyamines Review Article Pages 147-150 Irwin W. Sherman Chapter 18 New Permeability Pathways and Transport Review Article Pages 151-170 Irwin W. Sherman Chapter 19 Hemoglobinases Review Article Pages 171-179 Irwin W. Sherman Chapter 20 Erythrocyte Surface Membrane Proteins Review Article Pages 181-204 Irwin W. Sherman Chapter 21 Trafficking Review Article Pages 205-214 Irwin W. Sherman Chapter 22 Erythrocyte Membrane Lipids Review Article Pages 215-227 Irwin W. Sherman Chapter 23 Invasion of Erythrocytes Review Article Pages 229-252 Irwin W. Sherman Chapter 24 Vitamins and Anti‐Oxidant Defenses Review Article Pages 253-269 Irwin W. Sherman Chapter 25 Shocks and Clocks Review Article Pages 271-277 Irwin W. Sherman Chapter 26 Transcriptomes, Proteomes and Data Mining Review Article Pages 279-298 Irwin W. Sherman Chapter 27 Mosquito Interactions Review Article Pages 299-323 Irwin W. Sherman References Review Article Pages 325-394 Irwin W. Sherman Index Pages 395-402 Contents of Previous Volumes Pages 403-409 Malaria is one of the most common infectious diseases and an enormous public health problem. Each year it causes disease in approximately 650 million people and kills between 1 and 3 million, most of them young children in Sub-Saharan Africa.

This book provides an overview of the research that has been done in malaria biochemistry in the quest to find a cure. It discusses how our understanding has helped us to develop better diagnostics and novel chemotherapies. Researchers will find having all of this information in one volume, annotated with personal reflections from a leader in the field, invaluable given the big push being made on various fronts to use the latest drug discovery tools to attack malaria and other developing country diseases.

* Reviews the past 100 years of malaria biochemistry research providing researchers with an overview of the investigations that have been undertaken in this field
Benefit: Allows researchers to see what progress has been made so that they can use this knowledge when trying to develop the latest drug discovery tools to attack malaria

* Chronicles both biochemical successes and failures
Benefit: Allows researchers to see what has and hasn't work which they can then apply in their own research