Redox Regulation of Cell Signaling and Its Clinical Application (Oxidative Stress and Disease, 3)

Presents recent developments in the rapidly expanding field of redox regulation research. The book examines insights into intracellular communication and new techniques for diagnosing and treating diseases associated with oxidation and reduction. It focuses on important cellular mechanisms, such as redox reactions related to thioredoxin (TRX)/adult T-cell leukemia-derived factor (ADF). The book contains black-and-white illustrations. This up-to-the minute resource presents the most recent developments in the rapidly expanding field of redox regulation research, embracing new insights into intracellular communication and new techniques for diagnosing and treating diseases associated with oxidation and reduction. The book clarifies causes and consequences of oxidative stress and offers promising methods of its control. It focuses on important cellular mechanisms, such as redox reactions related to thioredoxin (TRX)/adult T-cell leukemia-derived factor (ADF), redox regulation of cell signaling, and its clinical application. Described are agents that defend cells against oxidative stress, including glutathione S-transferases (GST). The incidence of cellular damage and apoptotic cell death from glycation reaction and the role of advanced glycation end products (AGEs) in uremia and other critical conditions are presented. Hypothetical mechanisms, such as "on-off switches" in signal transduction and "cross-talk" between conformation-oriented and redox-oriented signals are discussed. This book explains causes of immunosuppression in cancer patients as a result of reduced CD3 associated with oxidative stress and elucidates the behavior of glucocorticoid and T-cell receptors in cell signaling and processes, such as redox regulation of NFB. It demonstrates how redox pathways transmit signals in reaction to extracellular oxidative stress and minor changes in intracellular environment and more. The thioredoxin (TRX) system, which is composed of NADPH, TRX, and TRX reductase, has been characterized from a wide variety of prokaryotic and eukaryotic species (1,2).