Receptors for Extracellular Matrix (Biology of Extracellular Matrix)

Receptors for Extracellular Matrix covers the major receptor families and their potential biological functions. Composed of eight chapters, the book first discusses the structure and function of membrane-associated proteoglycans, focusing on two classes of integral membrane molecules: syndecan and CD44. It then examines the important area of mechanisms of signal transduction from integrin receptors that must mediate the effects of extracellular matrices and other ligands on cell behavior. Multidomain proteins of the extracellular matrix and their role in controlling cellular growth are also considered. This book also discusses the significant research developments in NCAM, the most abundant and widespread of the known vertebrate cell-cell adhesion. The discussion particularly emphasizes the role of posttranslational glycosylation with polysialic acid in the function of the NCAM molecule that undergoes unusual and highly characteristic differences in glycosylation during development. Other chapters deal with the regulation of neural development by the extracellular matrix and the molecular basis of cell adhesion. This book includes discussions on the interaction of adhesion receptors with well-characterized cellular recognition sites and extracellular ligands and cell migration occurring during embryogenesis, gastrulation, neural crest cell migration, neurite extension, lymphocyte migration, and wound healing. The concluding chapters address the wide array of integrin associations, their physiologic relevance and structural aspects, as well as the anchorin CII, a collagen-binding protein of the calpactin-lipocortin family. This book is of great value to cell biologists and researchers. Content: Biology of Extracellular Matrix Series , Page ii Front Matter , Page iii Copyright , Page iv Contributors , Pages ix-x Preface , Pages xi-xiii , John A. McDonald, Robert P. Mecham Binding of Extracellular Effector Molecules by Cell Surface Proteoglycans , Pages 1-37 , Markku Jalkanen, Sirpa Jalkanen, Merton Bernfield Macrophage and Inflammatory Cell Matrix Receptors: LFA-1, Mac-1, p150,95 Family , Pages 39-78 , Eric J. Brown, Irene L. Graham Multidomain Proteins of the Extracellular Matrix and Cellular Growth , Pages 79-129 , Peter End, Jürgen Engel Neural Cell Adhesion Molecule and Polysialic Acid , Pages 131-156 , Urs S. Rutishauser Regulation of Neural Development by the Extracellular Matrix , Pages 157-193 , Louis F. Reichardt, Kevin J. Tomaselli Matrix Receptors in Cell Migration , Pages 195-253 , Martin J. Humphries, A. Paul Mould, Kenneth M. Yamada Structures and Functions of VLA Proteins and Related Integrins , Pages 255-300 , Martin E. Hemler Anchorin CII, A Collagen-Binding Protein of the Calpactin—Lipocortin Family , Pages 301-322 , Klaus von der Mark, Michael Pfäffle, Clementine Hofmann, Monika Borchert, Jürgen Mollenhauer Index , Pages 323-330 Focusing on the structure and function of matrix receptors, this book integrates data about several families and discusses such topics as receptors for extracellular matrix components, cell-matrix interactions in development, integrins, and the effects of extracellular matrix on gene expression.