Receptors and Other Targets for Toxic Substances : Proceedings of the European Society of Toxicology, Meeting Held in Budapest, June 11–14, 1984

Front Matter....Pages I-XIII On the Occasion of the 25th Meeting of the European Society of Toxicology....Pages 1-5 Young Scientists Award Lecture 1984 : Species Differences in Carcinogenicity and Peroxisome Proliferation due to Trichloroethylene: A Biochemical Human Hazard Assessment....Pages 6-17 Front Matter....Pages 19-19 The Role of Immunoreceptors....Pages 21-32 The Role of the Estrogen Receptor in Diethylstilbestrol Toxicity....Pages 33-42 The Role of Receptors in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Toxicity....Pages 43-60 The Oncogene and its Potential Role in Carcinogenesis....Pages 61-72 Brain Glucocorticoid Receptors and Their Role in Behavioural Teratogenicity of Synthetic Glucocorticoids....Pages 73-76 Effect of Dithiocarbamate Fungicides and Thiurams on 3 H-haloperidol Binding in Rat Brain....Pages 77-79 Front Matter....Pages 81-81 Mucosal Biotransformation of Toxins in the Gut....Pages 83-86 Intestinal Excretion of Toxic Substances....Pages 87-93 Biochemical Changes of Intestinal Epithelial Cells Induced by Cytostatic Agents in Rats....Pages 94-103 Intestinal Pathology in the Dog Induced by Sublethal Doses of Amiodarone....Pages 104-109 Distribution of Glutathione and its Related Enzymes in Small Intestinal Mucosa of Rats....Pages 110-113 Induction of Forestomach Lesions by Butylhydroxyanisole and Structurally Related Substances....Pages 114-116 The Effect of Cyclophosphamide and Vincristine on Intestinal Protein Loss in Rats....Pages 117-121 The Induction and Assessment of Rat Gastric Mucosal Lesions....Pages 122-122 The Technique of Gastric Endoscopy and Biopsy in the Dog....Pages 123-123 The Incidence of Neoplasms in Syrian Hamsters with Particular Emphasis on Intestinal Neoplasia....Pages 124-127 Front Matter....Pages 129-129 Thrombogenic Effects of Xenobiotics....Pages 131-141 Toxicologically Relevant Disturbances of Haemostasis....Pages 142-147 Front Matter....Pages 129-129 Effects of Organic Solvents on Erythrocyte Membrane Acetylcholine Esterase Activity....Pages 148-151 Changes of Haemostaseological Variables in Carbon Tetrachloride Poisoning in Rats....Pages 152-155 Influence of Antithrombin III on Carbon Tetrachloride Intoxication of Rabbits....Pages 156-159 Increased Serum Alkaline Phosphatase Activity in Beagle Dogs: Mechanism, Diagnostic Considerations....Pages 160-160 Interaction of Rodenticides and Humic Acids — Effects on Prothrombin Activity....Pages 161-161 Front Matter....Pages 163-163 Reasons for Monitoring Kinetics in Safety Evaluation Studies....Pages 165-172 A Decision Tree Approach for the Application of Drug Metabolism and Kinetic Studies to in Vivo and in Vitro Toxicological and Pharmacological Testing....Pages 173-188 Theoretical Aspects Pertinent to the Interpretation of Concentration Data....Pages 189-195 How to Identify Compounds Posing Problems in Absorption, Distribution and Elimination....Pages 196-204 A Questionnaire Assessing the Involvement of Toxicologists in Metabolism and Kinetics....Pages 205-207 A Stochastic Approach in the Evaluation of Plasma Curves with Enterohepatic Recycling....Pages 208-210 Endotoxin and Pharmacokinetics of Rifampicin....Pages 211-215 Local Toxicity and Pharmacokinetics After Intramuscular or Intralipomatous Injection of Different Drugs in Pigs....Pages 216-217 Distribution of Metabolites of the Potent β -Adrenoceptor Blocking Drug B 24/76 in Different Tissues of Rats Under Toxic Conditions....Pages 218-218 Front Matter....Pages 219-219 Principles in Cochlear Toxicity....Pages 221-239 Link Between Functional and Morphological Changes in the Inner Ear — Functional Changes Produced by Ototoxic Agents and Their Interactions....Pages 240-250 Front Matter....Pages 251-251 The Effect of Maneb, Zineb, and Ethylenethiourea on the Humoral Activity of the Pituitary-Thyroid Axis in Rat....Pages 253-258 Toxicokinetics of the Herbicide Dichlorprop and its Leucinate and Their Action on Liver Mixed Function Oxidase in Rats....Pages 259-263 Organochlorines and Mercury in Blood of a Fish-Eating Population at the River Elbe in Schleswig-Holstein, FRG....Pages 264-268 Pesticide—Drug Interaction in Rats....Pages 269-271 Front Matter....Pages 251-251 Dithiocarbamate Fungicides Decrease Histochemical Reactivity of Cholinesterases in the Gut Wall of the Rat....Pages 272-276 Biochemical Study of Muscle Samples from Chicken Embryos Affected by Wofatox 50 EC....Pages 277-279 Investigation of Adrenal Steroids and 25-Hydroxy-cholecalcipherol in Human Gramoxone Poisoning....Pages 280-283 Group Intoxication with Gramoxone (Paraquat) Toxicological and Pathohistological Aspects....Pages 284-284 The Genetic Control of Paraquat Sensitivity of H-2 Congenic and Recombinant Mice....Pages 285-286 The Effect of Light on the Toxicity of Paraquat in the Mouse....Pages 287-287 Changes of the Serum Superoxide Dismutase Content in Gramoxone Poisoned Patients, Measured by Anti-SOD Monoclonal Antibody....Pages 288-288 Cardiodepression in Organophosphate Poisonings....Pages 289-291 The Effect of Organophosphoric Pesticides on T- and B-Lymphocytes and Antibody Production in Mice....Pages 292-293 Toxicity Study of Insecticide Ekalux 25 EC in Rats....Pages 294-294 Effect of Different Antidotes in Ekalux 25 EC Poisoned Male Rats....Pages 295-296 Assessment of Acute Neurotoxic Effects of Different Kinds of Pesticides in Mice....Pages 297-297 Subacute and Subchronic Toxicity of Dietary Bendiocarb in Rats....Pages 298-298 Effect of Lethal Dose of Thrichlorphon on Different Biochemical and Physiological Parameters of Common Carp (Cyprinus Carpio L.)....Pages 299-299 Chlorate Poisoning: Mechanism of Toxicity....Pages 300-300 Effect of Nabam and Ethylenethiourea on the Urinary Output of Rats....Pages 301-302 Decis and Perocin Influence on the Activity of Serum Monoamine-Oxidase in Greenhouse Workers....Pages 303-304 Immunotoxicological Investigation of the Effects of a Pesticide; Cypermethrin....Pages 305-309 Front Matter....Pages 311-311 Effect of Some Heavy Metal Salts on Hepatic Monooxygenases After Subchronic Exposure....Pages 313-315 Intestinal Absorption of Aluminium in Rats....Pages 316-318 Front Matter....Pages 311-311 The Formation of Glutathione-Chromium Complexes and Their Possible Role in Chromium Disposition....Pages 319-321 Long-Term Exposure to Cadmium and Cardiovascular Alterations in the Rabbit....Pages 322-326 Lack of Substantial Neuroendocrine Changes in Short-Term High Dose Cadmium treated Rats....Pages 327-328 Effect of Cadmium on Proteins....Pages 329-329 Interaction of Tin and Zinc in Some Processes of Heme Biosynthesis in Rabbits....Pages 330-331 The Effect of Chronic Thallium Administration on Testicular Enzyme Activities in the Rat....Pages 332-333 Front Matter....Pages 335-335 The Effects of Methylglyoxal on Central Synaptic Transmission in the Isolated Nerve Cord of the Cockroach ( Periplaneta Americana L)....Pages 337-341 The Role of Bile Acids in the Effect of Ethinylestradiol on the Biliary Excretion of Exogenous Organic Anions....Pages 342-344 Substrate and Phenobarbital Induction of the Biliary Excretion of Exogenous Organic Anions in Rats....Pages 345-347 The Biliary Elimination of Sulfamerazin in Rat and Man — a Comparison....Pages 348-350 Preclinical Safety Studies with Temofel, a New Choleretic Compound....Pages 351-356 Studies on Hyperoxaluria and Oxalate Stone Formation Induced by 2-Acetyl-3-Phenyl-Tetrahydro-1,2,4-Oxadiazim-5-On....Pages 357-358 The Biliary Elimination of Indomethacin in Man....Pages 359-360 Increased Response of Cytochrome P-450 Dependent Biotransformation Reactions in Rat Liver to Repeated Administration of Inducers....Pages 361-365 Influence of Pyrazolones on Hepatic Glutathione in Rats....Pages 366-369 Comparative Study on the Sensitivity of Several Serum Enzymes in Detecting Hepatic Damage in Rats....Pages 370-372 The Metabolism of Some Xenobiotics in Germ-Free and Conventional Rats....Pages 373-376 The Effect of Prostacyclin on the Liver....Pages 377-378 Role of Vitamins in Biotransformation of Xenobiotics....Pages 379-379 Possible Adrenal Involvement in Hydroxyurea Toxicity Defense Mechanisms....Pages 380-384 Front Matter....Pages 335-335 Replacement Therapy Against Increased Hydroxyurea Toxicity in Pituitary or Adrenal Ablated Rats....Pages 385-389 Testicular Toxicity of Antineoplastic Drugs During Postnatal Development of the Rat....Pages 390-393 Free and Bound Testosterone in Male Heroin Addicts....Pages 394-397 Effect of Single Treatment of Rats with Procarbazine on the Pituitary-Testicular Axis....Pages 398-399 Toxic Effects of 3,7-Dimethylxanthine on Mature and Immature Male Rabbits....Pages 400-400 Pharmokinetics of Metoprolol in Relation to Polymorphic Sparteine Oxidation....Pages 401-402 Mutagenic Metabolites in Rat Urine After Dermal Exposure to 1,3-Diaminobenzene....Pages 403-406 Genotoxicity of Hexachlorobutadiene and Pentachlorobutenoic Acid: Correlation Between Induction of Unscheduled DNA Synthesis and Morphological Transformation in Syrian Hamster Embryo Fibroblasts....Pages 407-407 Genotoxic Activity of Nitroimidazo(2,1-b)Thiazole Derivatives in Salmonella Typhimurium and Saccharomyces Cerevisiae Assays....Pages 408-408 Serum Enzymes in Toxicity of Trichloroethylene After Subchronic Ethanol Pretreatment....Pages 409-411 Oral Intake of a Toluene-Containing Thinner. Effects and Headspace Gas Chromatographic Analytical Diagnosis....Pages 412-415 Circadian, Seasonal, and Social Factors Influencing the Organic Solvent Toxicity....Pages 416-417 Inhalation of Butanols: Changes in the Cytochrome P-450 Enzyme System....Pages 418-421 Circulating Steroids in Male Rats Following Inhalation of n-Alcohols....Pages 422-424 On the Embryotoxic Effects of Benzene and Its Alkyl Derivatives in Mice, Rats and Rabbits....Pages 425-430 Biological Response to Nitrogen Oxide....Pages 431-431 The Use of Whole Embryo Culture in the Study of Teratogenic Mechanisms....Pages 432-433 Behavioural Tests in the Postnatal Period After Prenatal Administration of Cyclophosphamide to Wistar Rats....Pages 434-434 Grip Strength Test and Infrared Thermometry as Non-Invasive Methods to Complement Acute Toxicity Data in Mice....Pages 435-441 Behavioural Effects of Prenatal Exposure to Carbon Disulphide and to Aromatol in Rats....Pages 442-446 Front Matter....Pages 335-335 Styrene Metabolism and Striatal Dopamine Depletion in Rabbits....Pages 447-450 The Influence of Ethanol Pretreatment and Social Isolation on Dopamine Release and Locomotor Activity in Mice....Pages 451-451 Metabolic Fate and Cardiovascular Effects of Arsenic in Rats and Rabbits Chronically Exposed to Trivalent and Pentavalent Arsenic....Pages 452-455 Relationship Between the Myocardial Concentrations of Anthracycline Antibiotics and Their Cardiotoxic Activity in the Rat....Pages 456-457 On the Safety Evaluation of Extracts from Synthetic Polymers used in Medicine....Pages 458-460 Intramuscular Injection and Muscle Damage: Comparison Between Morphologic and Enzymatic Changes After Irritants, Drugs and Solvents Administration in Rabbits....Pages 461-462 A Six Month Dermal Irritation Test with Anthralins in the Göttingen Miniature Swine....Pages 463-468 Separation of Immature and Adult Rat Hepatocytes into Distinct Subpopulations by Centrifugal Elutriation....Pages 469-473 Tests for Local Toxicity of Intramuscular Drug Preparations. Comparison of in Vitro and in Vivo Methods....Pages 474-475 Analysis of Cataract and Keratotic Damage Induced by 4-Diethylaminoethoxy-α-Ethyl-Benzhydrol (RGH-6201) in Rats....Pages 476-479 Applicability of Evans Blue Diffusion for Predicting Eye and Skin Irritancy to Chemicals in the Rat....Pages 480-480 Prediction of Toxicity Using Quantitative Structure-Activity Relationships....Pages 481-487 Structure-Activity Adverse Effect Relationship of Condensated As-Triazine Derivatives....Pages 488-488 A Mathematical Model Describing the Lethal Effects of High Temperature on Fish and Its Possible Application in the Planning of Toxicological Experiments....Pages 489-489 In Vivo Formation of a Carcinogenic Substance from Diethyl Pyrocarbonate in the Presence of Ammonia....Pages 490-493 Subacute Oral Toxicity of Allyl Isothiocyanate in the Rat....Pages 494-494 Preclinical Toxicity Studies with two Thymopoietin-Like Peptides....Pages 495-498 Comparative Studies on the Effect of Some Macrolide Antibiotics on Their Own Demethylation....Pages 499-499 Ecto-ATPase Activity in Rat and Mouse Thymocytes and Cytotoxic Effects of Various Chemical Substances in Vitro....Pages 500-503 Toxicity of the Alkylating Agent Bendamustin....Pages 504-506 Front Matter....Pages 335-335 The Leukemogenic Effect of Haloperidol in AKC3 F 1 Hybrid Mice....Pages 507-508 Back Matter....Pages 509-519