Recent Advances and Future Directions in Bone Marrow Transplantation : Proceedings of a Symposium Held in Conjunction with the 16th Annual Meeting of the International Society for Experimental Hematology, August 23–28, 1987, Tokyo, Japan

Siegmund J. Baum It has become a tradition to commence advocated by Leonard Cole) (3). important meetings of this society with At about the same time, Alpen and reminiscence and nostalgia. Bone marrow Baum (4), using a larger mammal, the dog, transplantation, which has a history of only demonstrated that injecting autologous marrow 30 to 40 years, permits this process, since post irradiation would protect lethally some of the early investigators are still with irradiated animals (see Table). Certainly, us. For example, over the past 15 years, we protection was obtained from the cellular have had three symposia in honor of Egon constituents of the bone marrow. Lorenz. As we all know, the team of Lorenz, We undertook to test on dogs the Uphoff and Congdon was involved in the first hypothesis of Gengozian and Makinodum (5) that successful transplantation of syngeneic and increasing the radiation dose will increase allogeneic bone marrow into irradiated immunologic tolerance for allogeneic implants. Front Matter....Pages i-xxiii Introduction....Pages 1-2 Graft-versus-Host Disease and Graft-versus-Leukemia in Experimental Systems....Pages 3-11 Syngeneic Graft-versus-Host Disease: Failure of Self: Non-Self Discrimination....Pages 12-17 Transfusion-Induced Allosensitization in Marrow Transplant Recipients: Mechanisms and Preventive Measures....Pages 18-23 Utilization of Monoclonal Antibodies for Autologous Bone Marrow Transplantation....Pages 24-30 Characterization of Malignant Lymphoma in Dogs and Use as a Model for the Development of Treatment Strategies....Pages 31-35 Hematopoietic Cell Transplantation in Murine Globoid Cell Leukodystrophy (The Twitcher Mouse)—A Model of a Human Sphingolipidosis (Krabbe Disease)....Pages 36-44 Experimental Basis of Bone Marrow Purging with Chemical and Photodynamic Agents....Pages 45-48 Oncogenes in Acute Myelogenous Leukemia....Pages 49-52 Optimal Timing of Marrow Transplantation for Patients with Acute Nonlymphoblastic and Acute Lymphoblastic Leukemia....Pages 53-57 Perspectives in Treatment of Adult Leukemia with High Dose Cytoreductive Therapy and Autologous Bone Marrow Treated Ex Vivo....Pages 58-73 Allogeneic and Autologous Marrow Transplants in Acute Nonlymphoblastic Leukemia (ANLL)....Pages 74-81 Allogeneic Transplantation for Acute Lymphoblastic Leukemia....Pages 82-88 Autologous Bone Marrow Transplantation in Acute Lymphoblastic Leukemia—Mafosfamide Italian Study Group....Pages 89-93 Allogeneic Bone Marrow Transplantation for Chronic Myeloid Leukemia....Pages 94-98 Autologous Marrow Transplantation for Hodgkin’s and Non-Hodgkin’s Lymphoma: Preliminary Results Using New Conditioning Regimens....Pages 99-105 Long-Term Bone Marrow Culture in Autologous Transplantation: An In Vitro Biological System for Purging Leukemic Cells....Pages 106-113 Allogeneic Bone Marrow Transplantation for Leukemia—Japanese Experience....Pages 114-118 Allogeneic and Syngeneic Marrow Transplantation for Aplastic Anemia: Overview of Seattle....Pages 119-124 Recent Advances and Future Trends in Bone Marrow Transplantation for Severe Aplastic Anemia....Pages 125-129 Allogeneic Bone Marow Transplantation in Leukemia....Pages 130-133 Bone Marrow Transplantation: The Difficulties Ahead....Pages 134-140 Predictive Models of Graft versus Host Disease....Pages 141-144 Prevention of Severe GVHD Employing Cyclosporine in HLA-Matched Marrow Transplant for Leukemia....Pages 145-149 Chronic Graft-versus-Host Disease: Pathogenesis, Diagnosis, Treatment, and Prognostic Factors....Pages 150-157 The Role of Autoreactive T Lymphocytes in Graft-versus-Host Disease (GVHD)....Pages 158-160 Predictive Factors for Chronic Graft-versus-Host Disease and Leukemic Relapse After Allogeneic Bone Marrow Transplantation....Pages 161-164 Viral Infection Following Bone Marrow Transplantation....Pages 165-170 Bacterial, Fungal, and Protozoan Infection After Marrow Transplantation....Pages 171-176 Prevention and Treatment of Infections After Bone Marrow Transplantation....Pages 177-186 Bone Marrow Transplantation for Thalassemia: 156 Cases Transplanted in Pesaro....Pages 187-188 Improvement of Clinical Expression of Central Nervous System Manifestation in Lysosomal Storage Diseases Treated by Bone Marrow Transplantation....Pages 189-194 Bone Marrow Transplantation Following Nuclear Accidents....Pages 195-199 Conclusions....Pages 200-200 This volume demonstrates the great progress made since the first successful allogeneic marrow transplants were performed in man over twenty years ago and also confronts today's unresolved significant problems. These include acute and chronic graft-versus-host disease, infection after bone marrow transplantation, and leukemic relapses. Discussion of experimental bone marrow transplantation focuses on such topics as the following: failure of self/nonself discrimination, prevention of transfusion-induced sensitization in marrow transplant recipients, bone marrow purging with chemical and photodynamic agents, autologous and allogeneic marrow transplants in leukemia and lymphoma, allogeneic and syngeneic marrow transplantation for aplastic anemia, marrow transplantation in patients with thalassemia and lysosomal storage diseases, and medical management of Chernobyl-type nuclear accidents