Ras superfamily small G proteins : biology and mechanisms. Volume 2, Transport

This second of two volumes discusses subfamily proteins which function in molecular and vesicular transport mechanisms inside the cell. In this volume the focus lies on the Rab, Ran and Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 this book provides an comprehensive state-of-the-art work on small G-proteins (GTPases). It is written for Graduates and Professors in Biochemistry and Cell Biology interested in the mechanism and function of small G-proteins but are extremely valuable for those who want to move into the field. Front Matter....Pages i-vi Front Matter....Pages 1-1 Prenylation of RabGTPases, Their Delivery to Membranes, and Rab Recycling....Pages 3-16 Rab Proteins and the Organization of Organelle Membrane Domains....Pages 17-38 Effectors of Rab GTPases: Rab Binding Specificity and Their Role in Coordination of Rab Function and Localization....Pages 39-66 A Rab Effector Called the Exocyst and Related Vesicle Tether Complexes....Pages 67-79 Rab GEFs and GAPs: The Enigma Variations....Pages 81-106 Front Matter....Pages 107-107 Ran in Nucleocytoplasmic Transport....Pages 109-124 Ran in Mitosis....Pages 125-148 Front Matter....Pages 149-149 Arf Proteins and Their Regulators: At the Interface Between Membrane Lipids and the Protein Trafficking Machinery....Pages 151-180 Small G Proteins: Arf Family GTPases in Vesicular Transport....Pages 181-214 ARF-Like (ARL) Proteins....Pages 215-251 ArfGAPs: Not Only for the Termination....Pages 253-274 Front Matter....Pages 275-275 Rag GTPases....Pages 277-292 Back Matter....Pages 293-298 This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field This second of two volumes discusses subfamily proteins involved in nucleo-cytoplasmic and vesicular transport mechanisms inside the cell. In this volume, the focus lies on the Rab, Ran and Arf subfamily members. Like Volume 1, the book was written by internationally renowned scientists in the field of small G-proteins. The biochemistry, structure, function and G-protein/effector interactions are described in detailed reviews. Together with Volume 1, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It was written for graduates and professors in biochemistry and cell biology interested in the mechanism and function of small G-proteins, but also offers an extremely valuable resource for those readers who are new to the field