Rare Tumors In Children and Adolescents (Pediatric Oncology)

This is the first book to be devoted exclusively to rare tumors in children and adolescents, and its aim is to provide up-to-date information on their diagnosis and clinical management. The opening section addresses general issues including epidemiology, risk factors/etiology, biology and genetics, early detection, and screening. It also discusses solutions to assist in the management of rare tumors, such as international networking and internet platforms. In the second section, specific malignancies are described, with practical guidance on diagnostic workup, multimodal therapy, follow-up, and adverse effects. Discussion of differential diagnosis encompasses both frequent and rare tumor types, which should enable the clinician to take rare entities into account during the diagnostic assessment. Each chapter goes on to provide detailed therapeutic guidelines for specific rare tumors. The authors are a multidisciplinary group of specialists who have dedicated themselves to this group of tumors. Front Matter....Pages i-x Front Matter....Pages 1-1 Rare Tumors: A Different Perspective on Oncology....Pages 3-13 Showing Efficacy in Treating Rare Pediatric Tumors: Introduction to European Regulatory and Scientific Support Available to Investigators....Pages 15-31 Rare Tumors: Pathology and Biology Perspectives....Pages 33-40 Front Matter....Pages 41-41 Epidemiology....Pages 43-61 Biology and Etiology of Rare Pediatric Tumors....Pages 63-67 Genetic Predisposition and Genetic Susceptibility....Pages 69-94 Front Matter....Pages 95-95 France....Pages 97-98 Germany....Pages 99-101 Italy....Pages 103-106 Poland....Pages 107-108 The United Kingdom....Pages 109-112 The United States....Pages 113-115 The E X PeRT Initiative....Pages 117-118 Front Matter....Pages 119-119 Internet Resources....Pages 121-125 Front Matter....Pages 127-127 Differential Diagnosis of Head and Neck Tumors....Pages 129-132 Thyroid Carcinomas....Pages 133-144 Nasopharyngeal Carcinoma....Pages 145-159 Esthesioneuroblastoma....Pages 161-167 Germ Cell Tumors of the Head and Neck....Pages 169-173 Odontogenic Tumors....Pages 175-179 Front Matter....Pages 127-127 Salivary Gland Tumors....Pages 181-186 Laryngeal Tumors....Pages 187-192 Front Matter....Pages 193-193 Pathological Aspects of Mediastinal Tumors....Pages 195-203 Mediastinal Germ Cell Tumors....Pages 205-211 Pleuropulmonary Blastoma....Pages 213-221 Bronchial Carcinoids and Carcinomas....Pages 223-229 Pediatric Pleural Mesothelioma....Pages 231-237 Thymoma and Thymic Carcinoma....Pages 239-242 Front Matter....Pages 243-243 Pathology and Differential Diagnosis....Pages 245-254 Gastrointestinal Cancer Predisposition Syndromes....Pages 255-262 Tumors of the Esophagus and the Stomach....Pages 263-268 Intestinal Carcinomas....Pages 269-276 Neuroendocrine Tumors of the Appendix....Pages 277-278 Gastrointestinal Stromal Tumors....Pages 279-282 Pancreatic Tumors....Pages 283-301 Liver Tumors....Pages 303-312 Paediatric Peritoneal Mesothelioma....Pages 313-319 Retroperitoneal Tumors....Pages 321-323 Front Matter....Pages 325-325 Gonadal and Extragonadal Germ Cell Tumors, Sex Cord Stromal and Rare Gonadal Tumors....Pages 327-402 Rare Tumors of the Urinary Tract....Pages 403-419 Front Matter....Pages 325-325 Breast Cancer....Pages 421-427 Front Matter....Pages 429-429 Rare Tumors of the Peripheral Nervous System....Pages 431-452 Front Matter....Pages 453-453 Rare Tumors of the Skin and Subcutaneous Tissues....Pages 455-482 Front Matter....Pages 483-483 Rare Mesenchymal Tumors....Pages 485-517 Front Matter....Pages 519-519 Tumors of Unknown Primary....Pages 521-525 Front Matter....Pages 527-527 Rare Subsequent Primary Cancers in Pediatric Cancer Survivors....Pages 529-536 Back Matter....Pages 537-547 This is the first book to be devoted exclusively to rare tumors in children and adolescents, and its aim is to provide up-to-date information on their diagnosis and clinical management. The opening section of the book addresses general issues including epidemiology, risk factors/etiology, biology and genetics, prevention, early detection, and screening. It also discusses solutions to assist in the management of rare tumors, such as international networking and internet platforms, thus providing the reader with access to the developing clinical network for rare tumors in children. In the second section, specific malignancies are described, with practical guidance on diagnostic workup, multimodal therapy, survival outcome, follow-up, and adverse effects. These chapters are organized by site according to the clinician's approach to the patient. Each chapter includes an introduction to the differential diagnostic assessment of tumors at the site in question, encompassing both frequent and rare tumor types. This approach should enable the clinician to take rare entities into account during the diagnostic assessment, so that the initial diagnostic steps are performed optimally. Each chapter goes on to provide detailed therapeutic guidelines for specific rare tumors. The authors are a multidisciplinary group of specialists who have dedicated themselves to this group of tumors. This well-illustrated book will prove an invaluable source of information for all pediatricians and oncologists faced with the often difficult task of diagnosing and treating rare tumors in the pediatric age group