Radiotherapy, Surgery, and Immunotherapy (Cancer, a compresensive treatise, 6)

The history of the development of cancer therapy has been marked by a recurring pattern, one of initially exciting and encouraging results as new methods were introduced, followed by dismaying failures. The extremity of the disease and its high mortality have dictated that each means of damaging tumor cells would be rapidly explored and exploited as a mode of therapy, long before the correspond­ ing theory and technique were completely understood and perfected. Thus radiation was used as an antitumor agent almost immediately following recogni­ tion of its cytodestructive capability. Equally constant, following the rapid utilization of new therapeutic methods, has been a period of significant technical improvements. This second aspect of the pattern is also illustrated by the field of radiotherapy. New radiation sources, new methods of dosimetry, use of high-energy radiation, and other new techniques allowed the therapist to better focus upon the tumor and to improve the geometry of exposure. Thus, with each technical advance, the "reach" of radiotherapy was increased and damage to normal tissues was decreased. Inevitably, however, a limit was reached, a point at which clinicians and researchers realized they could go no further without returning to a more fundamental search, one based on the biology of the tumor cell itself. Front Matter....Pages i-xv Front Matter....Pages 1-1 Present Status of Radiation Therapy of Cancer: An Overview....Pages 3-38 Physics of Radiation Therapy....Pages 39-50 Molecular and Cellular Biology of Radiation Lethality....Pages 51-99 Cell Proliferation Kinetics and Radiation Therapy....Pages 101-137 Radiation Effects on Normal Tissues....Pages 139-180 Hypoxic Cell Sensitizers for Radiotherapy....Pages 181-223 Effects of Radiation on Animal Tumor Models....Pages 225-279 High-LET Radiations....Pages 281-315 Stem Cells, Nonproliferating Cells, and Their Kinetics in Normal and Neoplastic Tissues....Pages 317-398 Front Matter....Pages 399-399 The Changing Role of Surgery in the Treatment of Cancer....Pages 401-421 Front Matter....Pages 423-423 Immunotherapy of Human Cancer....Pages 425-532 Back Matter....Pages 533-544