Radiotherapy of Intraocular and Orbital Tumors

Radiotherapy of Intraocular and Orbital Tumors presents a new approach to the role of radiation therapy in the management of ophthalmic cancer. The indications for ultrasonography, computed tomography, and magnetic resonance imaging studies are analyzed, and treatment techniques, together with their results, are described for each tumor. Particle beam and plaque irradiation are reviewed, and conservative and surgical management of radiation effects are detailed. In the past, most books on this subject included a chapter on radiotherapy but emphasized the dangers of radiation complications. However, great progress in understanding the effects of irradiation upon the tissues of the eye and orbit, new therapeutic equipment, and new imaging techniques (CT, MRI) allow for careful treatment planning. This book has taken the long overdue step of reconsidering the role of irradiation of the eye so that it may take its place as a respected, rather than feared, treatment in the combined modality approach so important today. Together with experts in relevant fields, the editors have produced a refreshingly clear and thoroughly referenced volume which will be a valuable asset to all ophthalmologists, radiation oncologists, pediatricians, endocrinologists, oncologists, and residents in training, as well as to students in these disciplines. Front Matter....Pages I-XX Front Matter....Pages 1-1 Diagnostic Approaches to Posterior Uveal Melanoma....Pages 3-8 Histopathology of Uveal Malignant Melanoma and Other Uveal Tumors....Pages 9-18 Controversies in the Management of Posterior Uveal Melanoma....Pages 19-21 Treatment of Choroidal Melanomas with 106 Ru/ 106 Rh Beta Ray Applications....Pages 23-30 Primary Malignant Melanoma of the Uvea: Radioactive Plaque Therapy and Other Treatment Modalities....Pages 31-44 Particle Treatment of the Eye....Pages 45-55 Proton Beam Irradiation of Choroidal Melanomas at the PSI: Technique and Results....Pages 57-72 Histopatholgy Studies in Choroidal Melanomas After Unsuccessful Brachytherapy with 106 Ru/ 106 Rh Plaques....Pages 73-77 Thermoradiotherapy for Malignant Choroidal Melanoma: The Development of a New Microwave Hyperthermia System....Pages 79-85 Clinical Features and Management of Choroidal Hemangiomas, Including Those Occurring in Association with Sturge-Weber Syndrome....Pages 87-92 Radiation Therapy of Choroidal Metastases....Pages 93-97 Front Matter....Pages 99-99 Diagnosis and Management of Retinoblastoma....Pages 101-122 Genetics of Retinoblastoma....Pages 123-130 Histopathology of Retinoblastoma....Pages 131-140 Coagulation Treatment and Surgery in Retinoblastoma....Pages 141-145 Plaque Brachytherapy in the Treatment of Retinoblastoma....Pages 147-151 Hyperthermia in the Treatment of Intraocular Tumors, in Particular Retinoblastoma....Pages 153-168 Front Matter....Pages 169-169 Orbital Rhabdomyosarcoma....Pages 171-178 Optic Pathway Glioma....Pages 179-185 Radiation Therapy for Orbital Metastases....Pages 187-189 Front Matter....Pages 169-169 Graves’ Disease....Pages 191-197 Management of Orbital Lymphoma....Pages 199-204 Lymphoid Tumors of the Orbit....Pages 205-216 Tumors of the Eyelids and Their Treatment by Radiotherapy....Pages 217-225 Conjunctival Tumors and Their Radiotherapy....Pages 227-237 Epithelial Tumors of the Lacrimal Gland and Lacrimal Sac....Pages 239-244 Front Matter....Pages 245-245 Neurologic Symptoms and Signs in Ocular and Orbital Tumors....Pages 247-252 Radiation-Related Orbital Injury: Clinical Manifestations and Considerations for Surgical Repair....Pages 253-260 Effects of Ionizing Radiation on the Conjunctiva, Cornea, and Lens....Pages 261-270 Front Matter....Pages 271-271 Imaging of Diseases of the Orbit....Pages 273-282 Ultrasonic Diagnosis in Ophthalmologic Oncology....Pages 283-293 Imaging Studies of Intraocular Tumors....Pages 295-309 Fluorescein Angiography of Ocular Tumors....Pages 311-327 Front Matter....Pages 329-329 Radiation Techniques for the Treatment of Retinoblastoma and Orbital Tumors....Pages 331-345 Physical Aspects of Eye Plaque Brachytherapy Using Photon Emitters....Pages 347-361 Dosimetry of Ru/Rh-106 Ophthalmic Applicators....Pages 363-368 Ocular Iodine Plaque Therapy: Dosimetry and Treatment Planning....Pages 369-373 Radiosensitivity of Ocular and Orbital Structures....Pages 375-385 Morphologic Changes After Iodine-125 Plaque Irradiation of Rabbit Eyes....Pages 387-398 Morphologic Changes After Fractionated External Beam Therapy of Minipig Eyes....Pages 399-414 Back Matter....Pages 415-424