Radiotherapy for Non-Malignant Disorders - Contemporary Concepts and clinical Results (Medical Radiology Radiation Oncology)

This volume discusses the general background, radiobiology, radiophysics and clinical applications of radiation therapy in the treatment of non-malignant diseases. Within 39 chapters, it documents the rationale and indications for the use of state-of-the-art radiotherapy for various non-malignant disorders of the CNS, head and neck, eye, skin and soft tissues, bone and joints, and the vascular system. In so doing, it draws attention to and elucidates the scope for application of radiotherapy beyond the treatment of malignancies. Both the risks and the benefits of such treatment are fully considered, the former ranging from minor clinical problems to life-threatening diseases. With the assistance of many tables and colored figures, the extensive data from clinical studies are presented in a well-structured and informative way. Each chapter concludes with a list of key points, allowing the reader to quickly comprehend the main facts. Since this approach offers an interdisciplinary perspective, this book will be of interest not only to radiotherapists but also to many other practitioners and medical specialists, for example orthopedists, surgeons, and ophthalmologists. General Background -- 1. Radiobiological Principles / K.-r. Trott, F.-h. Kamprad And G. Hildebrandt -- 2. Side Effects And Long-term Risks From Radiotherapy Of Benign Diseases / K.-r. Trott And F.-h. Kamprad -- 3. Risk Assessment And Carcinogenesis Modelling / J. J. Broerse, J. T. M. Jansen And J. Zoetelief -- 4. Radiophysical Principles / U. Wolf And T. Wiezorek -- 5. Clinical Principles / M. H. Seegenschmiedt And U. Schafer -- 6. Irradiation Of Non-malignant Diseases: A Survey / J. W. H. Leer, P. Van Houtte And J. Davelaar -- 7. Patterns Of Care Study For Non-malignant Diseases In Germany / M. H. Seegenschmiedt And O. Micke / The German Cooperative Group On Benign Diseases (gcg-bd) -- Skin And Soft Tissue Disorders -- 8. Tumors, Hyperplasia, Dermatoses / R. G. Panizzon, R. O. Mirimanoff And M. H. Seegenschmiedt -- 9. Morbus Dupuytren / Morbus Ledderhose / M. H. Seegenschmiedt -- 10. Peyronie's Disease / L. Incrocci -- 11. Keloids And Hypertrophic Scars / B. Guix, A. Andres, P. Salort, J. I. Tello, I. Henriquez, J. A. Lejarcegui And M. H. Seegenschmiedt -- 12. Aggressive Fibromatosis/desmoid Tumors / O. Micke, H. T. Eich, F. Bruns, J. Heide, G. Gosheger And M. H. Seegenschmiedt -- Bone And Joint Disorders -- 13. Orthopaedic Examination, Tests And Clinical Scores / O. Micke And M. H. Seegenschmiedt -- 14. Rotator Cuff Syndrome (rcs) / B. Adamietz -- 15. Humeral Epicondylopathia (hep), Lateral And Medial Humeral Epicondylitis / M. H. Seegenschmiedt, Felicitas Guntrum And H. Krahl -- 16. Calcaneodynia: Plantar And Dorsal Heel Spur/heel Spur Syndrome / O. Micke, A. Ernst-stecken, R. Mucke And M. H. Seegenschmiedt -- 17. Degenerative Joint Disease/activated Osteoarthrosis Deformans: Hip/knee/shoulder/other Joints / G. Hildebrandt And F.-h. Kamprad -- 18. Heterotopic Ossifications; General Survey For All Sites / M. H. Seegenschmiedt, O. Micke And R. Heyd -- 19. Heterotopic Ossification Prophylaxis -- The Hip / O. Kolbl, W. E. Alberti And M. H. Seegenschmiedt -- 20. Heterotopic Ossifications After Head And Spinal Cord Injuries (hsci) / M.-l. Sautter-bihl, P. Lukas, E. Liebermeister, D. Maier And A. Nanassy -- 21. Pigmented Villonodular Synovitis (pvns) / R. Oppenkowski And M. H. Seegenschmiedt -- 22. Langerhans Cell Histiocytosis (lch) / T. Olschewski, O. Micke And M. H. Seegenschmiedt -- 23. Vertebral Hemangiomas (svh) / R. Heyd And M. H. Seegenschmiedt -- 24. Aneurysmal Bone Cyst (abc) / R. Heyd And M. H. Seegenschmiedt -- Vascular Disorders -- 25. Giant Hemangioma/kasabach-merritt Syndrome / P. Schueller, S. Hesselmann And O. Micke -- Eye Disorders -- 26. Graves' Orbitopathy / S. Staar, H. T. Eich And M. H. Seegenschmiedt -- 27. Pseudotumor Orbitae / M. Notter And K. M. Greven -- 28. Pterygium / R. H. Greiner, B. Pajic And J. Kutzner -- 29. Hemangiomas And Vascular Tumors Of The Eye / M. Murty, J. E. Freire, C. L. Shields, J. A. Shields, A. Mashayekhi And L. W. Brady -- Local And Systemic Inflammatory Disorders -- 30. Inflammatory Disorders: Furunculitis, Hidradenitis, Panaritium And Paronychia / D. Frohlich, D. Baaske And M. Glatzel -- 31. Lymphocutaneous Fistulas And Lymphoceles / B. Neu And W. Haase -- 32. Local Rheumatoid Arthritis And Radiation Synevectomy / G. M. Kacl And G. Stucki -- Head And Neck -- 33. Non-malignant Disorders Of The Head Region / R. Oppenkowski And M. H. Seegenschmiedt -- Cns And Brain -- 34. Arterio-venous Malformation / M. W. Gross And R. Engenhart-cabillic -- 35. Meningeoma / S. Milker-zabel And J. Debus -- 36. Vestibular Schwannoma (acoustic Neuroma) / A.-l. Grosu, E. Oestreicher, C. Fauser, C. Lumenta, W. J. Arnold And M. Molls -- 37. Pituitary Adenoma / D. Zierhut -- 38. Trigeminal Neuralgia / M. Attassi, M. H. Seegenschmiedt And M. Korner -- 39. Radiosurgical Treatment Options For Epileptic Disorders / H. G. Wieser -- 40. Where There Is No Evidence: Registry For Rare Benign Diseases / O. Micke, A. Koehler And M. H. Seegenschmiedt. M.h. Seegenschmiedt ... [et Al.] (eds.) ; With Contributions By B. Adamietz ... [et Al.] ; Foreword By L.w. Brady ... [et Al.]. Includes Bibliographical References And Index. cover......Page 1 front-matter......Page 2 Part I - General Background......Page 13 01 Radiobiological Principles.pdf......Page 14 02 Side Effects and Long-Term Risks from Radiotherapy of Non-malignant Diseases.pdf......Page 39 03 Risk Assessment and Carcinogenesis Modelling.pdf......Page 54 04 Radiophysical Principles.pdf......Page 68 05 Clinical Principles.pdf......Page 97 06 Irradiation of Non-malignant Diseases- An International Survey.pdf......Page 128 07 Patterns-of-Care Study for Non-malignant Diseases in Germany.pdf......Page 140 Part II - Skin and Soft Tissue Disorders......Page 151 08 Non-malignant Skin Disorders- Tumors, Hyperplasia, Dermatoses.pdf......Page 152 09 Morbus Dupuytren-Morbus Ledderhose.pdf......Page 165 10 Pronie’s Disease.pdf......Page 196 11 Keloids and Hypertrophie Scars.pdf......Page 211 12 Aggressive Fibromatosis-Desmoid Tumors.pdf......Page 227 Part III - Bone and Joint Disorders......Page 237 13 Orthopaedic Examination, Tests and Clinical Scores.pdf......Page 238 14 Rotator Cuff Syndrome (RCS).pdf......Page 261 15 Humeral Epicondylopathia (HEP), Lateral and Medial Humeral Epicondylitis.pdf......Page 280 16 Calcaneodynia- Plantar and Dorsal Heel Spur-Heel Spur Syndrome.pdf......Page 294 17 Degenerative Joint Disease Activated Osteoarthrosis Deformans- Hip, Knee, Shoulder and Other Joints.pdf......Page 315 18 Heterotopic Ossifications- General Survey for All Sites.pdf......Page 331 19 Heterotopic Ossification Prophylaxis - The Hip.pdf......Page 354 20 Heterotopic Ossifications after Head and Spinal Cord Injuries (HSCI).pdf......Page 369 21 Pigmented Villonodular Synovitis (PVNS).pdf......Page 378 22 Langerhans Cell Histiocytosis (LCH).pdf......Page 391 23 Vertebral Hemangioma (VH).pdf......Page 418 24 Aneurysmal Bone Cyst (ABC).pdf......Page 434 Part IV - Vascular Disorders......Page 449 25 Giant Hemangioma-Kasabach-Merritt Syndrome.pdf......Page 450 Part V - Eye Disorders......Page 458 26 Graves’ Orbitopathy.pdf......Page 459 27 Pseudotumor Orbitae.pdf......Page 477 28 Pterygium.pdf......Page 491 29 Hemangiomas and Vascular Tumors of the Eye.pdf......Page 503 Part VI - Local and Systemic Inflammatory Disorders......Page 511 30 Inflammatory Disorders- Furunculitis, Hidradenitis, Panaritium and Paronychia.pdf......Page 512 31 Lymphocutaneous Fistulas and Lymphoceles.pdf......Page 526 32 Local Rheumatoid Arthritis and Radiation Synovectomy.pdf......Page 536 Part VII - Head and Neck......Page 551 33 Non-Malignant Disorders of the Head Region.pdf......Page 552 Part VIII - CNS and Brain......Page 569 34 Arterio-Venous Malformations.pdf......Page 570 35 Meningioma.pdf......Page 595 36 Vestibular Schwannoma (Acoustic Neuroma).pdf......Page 615 37 Pituitary Adenoma.pdf......Page 639 38 Trigeminal Neuralgia.pdf......Page 650 39 Radiosurgical Treatment Options for Epileptic Disorders.pdf......Page 663 40 Where There is No Evidence- Registry for Rare Benign Diseases.pdf......Page 685 back-matter......Page 708 Non-malignant, or'benign', diseases can be successfully treated using ionizing rad- tion technologies. It was first proposed in 1898 by Sokoloff, who reported the analgesic effects of radiotherapy for painful rheumatoid arthritis. Since then, the use of these techniques for painful muscle-skeletal diseases has gained acceptance particularly in Europe but is still carried out actively in the United States. Non-malignant diseases that are amenable to radiotherapy can be classified as inflammatory, degenerative, hype- roliferative, functional, or other disorders. However, the topographic and morphologic considerations are more relevant. Even though radiation therapy for'benign'diseases has not been pursued actively since the 1950s, more recent interest has dictated that it can be a very effective treatment modality. The use of radiotherapy can be justified for invasive and aggressive growth such as that seen with desmoids, for cosmetic d- figurations and functional loss as seen with keloids or endocrine orbitopathy, or for life-threatening complications such as hepatic hemangiomas or juvenile angiofibromas that occur in children or adolescents. Many of the non-malignant diseases can have a major and lasting effect on quality of life by causing pain or other serious symptoms, particularly when other methods of treatment are unavailable, have failed, or may induce more side effects. It is not generally the first choice of therapy in these non-malignant diseases, but it is acceptable as defined. The book edited by Seegenschmiedt et al.