Radioactive Isotopes In Clinical Medicine And Research (advances In Pharmacological Sciences)

With the present Badgastein Symposium "Radioactive Isotopes in Clinical Medicine and Research" we have now had 40 years of an uninterrupted series of Badgastein meetings on nuclear medicine, since the first one took place in January 1954. We believe that this anni­ versary is worth mentioning. The 21 st symposium proved again to offer a representative cross­ section through the current topics of scientific interest of nuclear medicine. The general theme of research in nuclear medicine has shifted from the spectacular new developments which were so often reported in the first symposia to a less spectacular, albeit equally important period, which may best be characterized by validation and standardization. While this may not be as exciting as we would like it to be, it is nevertheless vital for nuclear medicine to maintain and improve its standing amongst the other specialties of medicine which draw upon the services that nuclear medicine offers. Front Matter....Pages I-XVIII Front Matter....Pages 1-1 Nuclear Medicine — Tool or Specialty?....Pages 3-7 Front Matter....Pages 9-9 Ventilation Scintigraphy of the Tympanic Cavity by Xenon-133....Pages 11-16 Assessment of Lung Injury with 67 Gallium in Patients with Pulmonary Edema. A Preliminary Analysis....Pages 17-22 A Model for Administered 81 Kr m Activity and a Method for Measurement: Some Recommendations for Patient and Staff Dose Reduction....Pages 23-28 Dosimetry of Intralesional 131 I-Monoclonal Antibody (MAb) Therapy in Patients with Recurrent High Grade Gliomas....Pages 29-34 Improved Control of Malignant Gliomas by Means of Intralesional Radioimmunotherapy....Pages 35-41 Front Matter....Pages 43-43 Thrombocytopenia in HIV, Idiopathic Thrombocytopenic Purpura (ITP), Vasculitis and Toxic Bone Marrow Injury: An Etiologic Entity ? Results of a Comparative Study....Pages 45-50 67 Ga Scintigraphy, MRI and CT in the Follow-Up of Malignant Lymphoma Patients with Residual Mediastinal Mass....Pages 51-56 Tumor Imaging Using a Tc-99m Labelled Immunomodulatorresults of Clinical Studies in Various Kinds of Malignant Tumors....Pages 57-63 Investigation of Breast Cancer with 18 Fluordeoxyglucose Using Conventional Gamma Camera System and Spect-Technique....Pages 65-70 Comparison of 123 I-α-Methyltyrosine SPECT and 11 C-L-Methionine PET in Patients with Brain Tumors....Pages 71-75 Front Matter....Pages 77-77 PET Image Reconstruction for Pharmacokinetic Modeling of 5-[ 18 F]Fluorouracil in Liver Tumors....Pages 79-84 Effects of Distorted PET Projection Data on the Reconstructed Image Using Different Reconstruction Algorithms....Pages 85-90 Noninvasive Determination of the Arterial Input Function: General Description for an Artery Surrounded by Homogeneous Tissue....Pages 91-96 Multimodal Image Registration for Radioimmunotherapy. Surface Landmark and Frame Based Correlation in Patients Undergoing Intralesional 131 I-MAb Therapy for Recurrent High Grade Glioma....Pages 97-104 Automatic Scaling of Static ‘Analogue-Equivalent’ Images Obtained from Digital Gamma Camera Systems....Pages 105-108 A Method for Determination of Regional Myocardial Blood Flow (RMBF) Considering Regional Spillover....Pages 109-115 Improvement of HMPAO Brain SPECT Evaluation Using a Kalman Filtering Approach....Pages 117-121 Bayesian Identification of Compartment Structures in Dynamic Scintigraphic Data....Pages 123-128 Dosimetry in LDR- and HDR-Brachytherapy by SPECT Measurements of Scattered Compton Photons....Pages 129-134 Front Matter....Pages 135-135 Residual Thallium Activity in Persistent Defects after Tracer Reinjection at Rest: A Marker of Myocardial Viability....Pages 137-142 Quantitative Relation between Resting Thallium-201 SPECT and 18F-Fluorodeoxyglucose SPECT in Normals....Pages 143-148 Viability of the Revascularized Myocardium....Pages 149-154 Positron-Spet Imaging with Rubidium-81 for Detection of Coronary Artery Disease Using a Special Design of a 511-keV Collimator for the Standard Gamma Camera....Pages 155-160 Quantitative Lymphoscintigraphy for the Evaluation of Lymphaticovenous Anastomosis (LVA) in Treatment of Upper Limb Edema (ULE)....Pages 161-166 Front Matter....Pages 167-167 Radioimmunoscintigraphy of Ovarian Tumours with Tc-99m Labelled Monoclonal Antibody-170....Pages 169-177 Immunoscintigraphy of Colorectal Cancer with Tc-99m-Labeled F(ab′)2 Fragments of the Anti-CEA MoAb F023C5 First Clinical Results....Pages 179-185 Radioimmunoscintigraphy of Malignant Melanoma with 99m Tc-Labelled Monoclonal Antibody BW 575....Pages 187-193 Estimation of Brain Perfusion by Evaluating the Angiographic Phase of Tc-99m-Hmpao-Studies....Pages 195-200 Acetazolamide Increases Cardiac Output....Pages 201-205 HMPAO-SPECT and FDG-PET in Huntington’s Disease: A Methodological Study Comparing the Performance of PET with That of a Three Headed SPECT Camera....Pages 207-210 Potential Usefulness of Stabilization Methods for 99m Tc-HMPAO in Cerebral Blood Flow Imaging....Pages 211-216 Pharmacokinetics and Biodistribution of [ 123 I]β-CIT in Humans....Pages 217-222 Front Matter....Pages 223-223 Scintigraphic Determination of the Functional Abnormality in Chronic Idiopathic Constipation....Pages 225-230 Is Kidney Allograft Perfusion Determined Essentially by Donor Characteristics? Results of a ‘Twin Study’.....Pages 231-236 TC/TL-3-D-Subtraction-SPECT of Parathyroid Glands (PTG) in Patients with Chronic Maintenance Hemodialysis and Secondary Hyperparathyroidism (SHPT)....Pages 237-240 Scatter Correction in Renal Clearance Studies with Radioiodine-Hippuran....Pages 241-245 Front Matter....Pages 247-247 The Tissue Characterisation of Malignancy with Radionuclide Studies....Pages 249-277 Front Matter....Pages 279-279 Optimized Preparation of the Dopaminergic Receptor Ligands 123 I-Epidepride and 123 I-CIT....Pages 281-286 Tc-99m Labelling and Biodistribution of Designed Molecules....Pages 287-292 Front Matter....Pages 279-279 Different Uptake of Iodo-Doxorubicin Labelled with I-123 in Tumour Cells of Gastric Carcinoma Being Sensitive and Resistant to Anthracyclines....Pages 293-296 The Reduction of the Liver Radioactivity after Application of Currently Used Tumour-Affine Radiopharmaceuticals....Pages 297-307 Deoxyglucose Uptake in Oestrogen-Ablated Rat Mammary Tumours....Pages 309-313 Interference of Patient Medication in the Radiolabelling of Blood Cells: In-Vitro and In-Vivo Effects....Pages 315-322 Front Matter....Pages 323-323 Volumetric Analysis of Antral Motor Activity....Pages 325-328 111 Indium Polyclonal Human Immunoglobulin G in Human and Experimental Atherosclerosis....Pages 329-334 SPECT-Quality-Control: Evaluating Center-of-Rotation Offset, Y-Shift and Detector Tilt by Means of a Single, Comprehensive Test....Pages 335-341 Front Matter....Pages 343-343 Acute Ethanol-Induced Changes in Cerebral Blood Flow....Pages 345-350 Experimental Studies of I-123-Labelled Iodo-Doxorubicin....Pages 351-355 Preparation and Quality Control of 153 Samarium-EDTMP for Radio-Therapy of Metastatic Bone Pain....Pages 357-360 Universally Valid Algorithms for GFR Determination Requiring a Single Plasma Sample....Pages 361-368 Scintigraphic Defaecography: Experience with 145 Patients....Pages 369-374 A PC LAN as a Flexible and Non-Expensive Implementation of a PACS....Pages 375-378 Scintigraphic Prediction of Residual Lung Function Following Lobectomy: The Use of Posterior Oblique Views....Pages 379-384 Front Matter....Pages 385-385 99 Tc m (V) DMSA and 111 In Pentetreotide in the Detection of Malignancies....Pages 387-391 Reliable Diagnosis of Pancreatic Adenocarcinoma with 18-F-2-FDG-Positron-Emission-Tomography (PET)....Pages 393-397 Recognition of Rhabdo- and Leiomyosarcomas by Means of in-111 Labeled Antimyosin-Antibody Fragments — An Improvement for the Oncologic Diagnostic....Pages 399-404 Uptake of 4-Iodo-Doxorubicin Labelled with I-123 and Tc-99m in Tumour Cells of Gastric Carcinoma and Suprarenal Gland Carcinoma....Pages 405-408 Platelet Uptake of 131 I — Metaiodobenzylguanidine — Mechanism, Extent and Clinical Relevance....Pages 409-413 Front Matter....Pages 415-415 Carotid Scintigraphy in Hypertensive Patients with Ultrasound Images of Intimal Thickening....Pages 417-422 Front Matter....Pages 415-415 Mean Transit Time of in-111-DTPA Through the CSF-Space for the Detection of Normal Pressure Hydrocephalus....Pages 423-428 Striatal Glucose Consumption in Various Choreatic Disorders....Pages 429-432 The Influence of Verapamil on Cardiac Uptake of I-123 Labelled Anthracyclines in Rabbits....Pages 433-438 Thyroglobulin and Its Meaning for the Forensic Medicine-Experiences in Studies Using an IRMA Test....Pages 439-444 Imaging of Parathyroid Adenomas Using Technetium-99m-Sestamibi in an Endemic Goiter Area....Pages 445-450 Back Matter....Pages 451-454 This volume reviews the latest developments in both clinical and basic nuclear medicine. It concentrates on the application of labelling or data analysis techniques to clinical problems and covers oncology, neurology, cardiology/angiology, instrumentation and image processing and other areas.