Radiation Health Risk Sciences: Proceedings of the First International Symposium of the Nagasaki University Global COE Program ''Global Strategic Center for Radiation Health Risk Control''

Radiation safety and risk management, a critical issue in the nuclear age, is an ongoing concern in the field of radiation health risk sciences. It is the particular mission and task of the Nagasaki University Global COE program to explore human health risks from radiation on a global scale and to come up with measures for overcoming its negative legacies. Ionizing radiation is a well-documented human cancer risk factor, and long-term health consequences in individuals exposed at a young age to such events as the Hiroshima and Nagasaki atomic bombing are now being followed up. Unique and comprehensive, this book introduces updated radiation health-related issues, including the proper collection and analysis of biological samples, cancer research, psychological effects, fair disclosure, and the effects of low-dose exposure as they apply to future public health policy. Also addressed is the need for emergency radiation medicine in case of accidents. Contents......Page 19 Acknowledgments......Page 5 Organizing Committee......Page 6 Group photograph......Page 7 Preface......Page 8 Greetings......Page 10 Addresses......Page 12 Contributors......Page 24 Overview of the Global COE Program......Page 34 Global Strategic Center for Radiation Health Risk Control......Page 35 Overview of the Lectures......Page 43 Discussion on Points of Radiation Safety and the Scope of The University of Tokyo Global COE Program......Page 44 Network System for Radiation Emergency Medicine in Japan and the Role of Hiroshima University......Page 54 Non-DNA-Targeted Effects and Low-Dose Radiation Risk......Page 60 Update from the Chernobyl Tissue Bank: Effect of Latency on Different Types of Thyroid Cancer Post-Chernobyl......Page 65 Current Risk Estimate of Radiation-Related Cancer and Our Insight into the Future......Page 74 Atomic Bomb Disease Medicine......Page 80 Introduction of Atomic Bomb Disease Medical Research in Global COE Program......Page 81 The Offspring of Atomic Bomb Survivors: Cancer and Non-Cancer Mortality and Cancer Incidence......Page 87 Ischemic Heart Disease Among Atomic Bomb Survivors: Possible Mechanism(s) Linking Ischemic Heart Disease and Radiation Exposure......Page 93 Leukemia, Lymphoma, and Multiple Myeloma Incidence in the LSS Cohort: 1950–2001......Page 99 Follow-Up Study of 78 Healthy Exposed Atomic Bomb Survivors for 35 Years in Hiroshima, with Special Reference to Multiple Cancers......Page 104 International Radiation Health Sciences......Page 109 Research Activities and Projects Within a Framework of International Radiation Health Sciences Research......Page 110 Age and Prognosis: Do Adjuvant Therapies Influence the Real Prognosis?......Page 119 Mortality of the Chernobyl Emergency Workers: Analysis of Dose Response by Cohort Studies Covering Follow-Up Period of 1992–2006......Page 124 Twenty Years After Chernobyl: Implications for Radiation Health Risk Control......Page 132 Fallout Exposure of the Population and Thyroid Nodular Diseases......Page 142 Radiation Basic Life Sciences, Part 1......Page 149 Higher-Order Chromatin Structure and Nontargeted Effects......Page 150 p53 Dependency of Delayed and Untargeted Recombination in Mouse Embryos Fertilized by Irradiated Sperm......Page 154 The Yin and Yang of Low-Dose Radiobiology......Page 162 Induction and Persistence of Cytogenetic Damage in Mouse Splenocytes Following Whole-Body X-Irradiation Analysed by Fluorescence In Situ Hybridisation. V. Heterogeneity/Chromosome Specificity......Page 170 Cancer Research......Page 177 Molecular Understanding of RET/PTC-Mediated Thyroid Carcinogenesis......Page 178 Molecular Prediction of Therapeutic Response and Adverse Effect of Chemotherapy in Breast Cancer......Page 202 Multiple Roles of NBS1 for Genotoxic and Nongenotoxic Stresses......Page 208 Radiation Basic Life Sciences, Part 2......Page 215 The DNA Damage Response in Nontargeted Cells......Page 216 The Role of Telomere Dysfunction in Driving Genomic Instability......Page 222 Secretory Clusterin Is a Marker of Tumor Progression Regulated by IGF-1 and Wnt Signaling Pathways......Page 227 Target of Radiation Carcinogenesis Is Protein: Becoming Triploid Is Proximate Cause of Cell Transformation......Page 235 Adult Stem Cells, the Barker Hypothesis, Epigenetic Events, and Low-Level Radiation Effects......Page 239 Combined Effect of Ionizing Radiation and N-Ethyl-N-Nitrosourea on Mutation Induction and Lymphoma Development......Page 250 γ-Ray-Induced Mouse Thymic Lymphomas: Bcl11b Inactivation and Prelymphoma Cells......Page 255 Radiation Risk Management......Page 263 Framework of Radiation Safety Management in Japan: Laws, Administrative Agencies, and Supporting Associations......Page 264 Background Radiation Dose to the Population Around the Kudankulam Nuclear Power Plant......Page 269 International Cooperation in Radiation Emergency Medical Preparedness: Establishment of a Medical Network in Asia......Page 275 Disaster and Mental Health......Page 281 Long-Term Biopsychosocial Consequences of Disaster: Focus on Atomic Bomb Survivors......Page 282 Health Status of Children Exposed to the Chernobyl Accident In Utero: Observations in 1989–2003 and the Implications for Prioritizing Prophylactic Programs......Page 290 Psychological Consequences More Than Half a Century After the Nagasaki Atomic Bombing......Page 296 Radiation and Cancer......Page 302 Significance of Oncogene Amplifications in Breast Cancer in Atomic Bomb Survivors: Associations with Radiation Exposure and Histological Grade......Page 303 Paracrine Interactions Between Normal, but Not Cancer, Epithelial and Normal Mesenchymal Cells Attenuate Radiation-Induced DNA Damage......Page 312 Chernobyl and Semipalatinsk Nuclear Test Sites: Related Issues......Page 320 Thyroid Cancer in Ukraine After the Chernobyl Accident: Incidence, Pathology, Treatment, and Molecular Biology......Page 321 Current Trends in Incidence and Mortality from Thyroid Cancer in Belarus......Page 333 The Health Status of the Population in the Semey Region and Scientifically Proven Measures to Improve It......Page 338 Nuclear Explosions and Public Health Development......Page 344 C......Page 350 G......Page 351 M......Page 352 R......Page 353 T......Page 354 X......Page 355 Introduces radiation health-related issues, including the proper collection and analysis of biological samples, cancer research, psychological effects, fair disclosure, and the effects of low-dose exposure as they apply to future public health policy. This work also addresses the need for emergency radiation medicine in case of accidents