Quality of life impairment in schizophrenia, mood, and anxiety disorders : new perspectives on research and treatment

Over the past few decades health-related quality of life (HRQL) has emerged as the new image of medicine viewed from a psychosocial perspective. The concept of Quality of Life has attracted a good deal of interest, not only from a clinical perspective but also from psychosocial, health economics as well as cultural aspects. More recently, the neurobiological brain substrates that modulate many aspects of subjective experiences, which is relevant to quality of life such as affect, mood, cognition, pleasure, reward responses as well as feeling of wellbeing and satisfaction has been explored and elucidated. Such increased interest in HRQL is highlighted by the large number of recent publications. Over the past 10 years at least 350 papers were published describing aspects of HRQL in the psychiatric and mental field. Among them 78% dealt with HRQL in schizophrenia and schizoaffective disorders, 21% with major depression, 14% with anxiety disorders and 4% with bipolar disorder. It is gratifying to witness the enhanced interest and popularity in HRQL research and publications, yet the field continues to suffer from conceptual inconsistencies as well as a good deal of methodological limitations. It is worrisome that we still do not have a clear understanding of the concept itself as applied to mental health and illness as well as the complex array of its determinants. Similarly there is a lag in the application of quality of life data in improving clinical practice. 978-1-4020-5779-3_BookFrontmatter_OnlinePDF.pdf 2 CONTENTS 5 CONTRIBUTORS 8 FOREWORD 12 978-1-4020-5779-3_1_Part_OnlinePDF.pdf 14 978-1-4020-5779-3_1_OnlinePDF.pdf 15 The Distress/Protection Vulnerability Model of Quality of Life Impairment Syndrome 15 978-1-4020-5779-3_2_OnlinePDF.pdf 32 Role of Dopamine in Pleasure, Reward and Subjective Responses to Drugs 32 978-1-4020-5779-3_3_OnlinePDF.pdf 43 Neuroendocrine functions, mood and quality of life 43 978-1-4020-5779-3_4_OnlinePDF.pdf 67 In the mind of the Beholder Neuronal mediators for the effect of emotional experience on quality of life 67 978-1-4020-5779-3_5_OnlinePDF.pdf 77 Cross-cultural Quality of Life Research in Mental Health 77 978-1-4020-5779-3_6_OnlinePDF.pdf 109 Measuring the value of health-related quality of life 109 978-1-4020-5779-3_7_OnlinePDF.pdf 143 Comparison of instruments for measuring the quality of life impairment syndrome in severe mental disorders 143 978-1-4020-5779-3_8_OnlinePDF.pdf 153 Integrative bottom-up approachto HRQOL measurement 153 978-1-4020-5779-3_2_Part_OnlinePDF.pdf 166 978-1-4020-5779-3_9_OnlinePDF.pdf 167 Health Related Quality of Life in Subjects at Risk for a First Episode Of Psychosis 167 978-1-4020-5779-3_10_OnlinePDF.pdf 180 Quality of life impairment syndrome in schizophrenia 180 978-1-4020-5779-3_11_OnlinePDF.pdf 234 Insight and quality of life in schizophrenia spectrum disorders 234 978-1-4020-5779-3_12_OnlinePDF.pdf 248 Quality of Life and Major Depression 248 978-1-4020-5779-3_13_OnlinePDF.pdf 260 Quality of life impairment in bipolar disorder 260 978-1-4020-5779-3_14_OnlinePDF.pdf 282 Quality of Life Impairment in Anxiety Disorders 282 978-1-4020-5779-3_15_OnlinePDF.pdf 299 Quality of Life in Obsessive-Compulsive Disorder 299 978-1-4020-5779-3_3_Part_OnlinePDF.pdf 310 978-1-4020-5779-3_16_OnlinePDF.pdf 311 Antipsychotic Medications, Schizophrenia and the Issue of Quality of Life 311 978-1-4020-5779-3_17_OnlinePDF.pdf 324 Quality of life outcomes of ECT 324 978-1-4020-5779-3_18_OnlinePDF.pdf 335 Quality of Life in Mental Health Services 335 978-1-4020-5779-3_19_OnlinePDF.pdf 356 Subjective quality of life in relation to psychiatric rehabilitation and daily life 356 978-1-4020-5779-3_20_OnlinePDF.pdf 374 Cost-utility analysis 374 978-1-4020-5779-3_BookBackmatter_OnlinePDF.pdf 386 INDEX 386 Front Matter....Pages I-XIV Front Matter....Pages 1-1 The Distress/Protection Vulnerability Model of Quality of Life Impairment Syndrome....Pages 3-19 Role of Dopamine in Pleasure, Reward and Subjective Responses to Drugs....Pages 21-31 Neuroendocrine functions, mood and quality of life....Pages 33-56 In the mind of the Beholder Neuronal mediators for the effect of emotional experience on~quality of life....Pages 57-66 Cross-cultural Quality of Life Research in Mental Health....Pages 67-98 Measuring the value of health-related quality of life....Pages 99-132 Comparison of instruments for measuring the quality of life impairment syndrome in severe mental disorders....Pages 133-142 Integrative bottom-up approach to HRQOL measurement....Pages 143-155 Front Matter....Pages 157-157 Health Related Quality of Life in Subjects at Risk for a First Episode Of Psychosis....Pages 159-171 Quality of life impairment syndrome in schizophrenia....Pages 173-226 Insight and quality of life in chizophrenia spectrum disorders....Pages 227-240 Quality of Life and Major Depression....Pages 241-252 Quality of life impairment in bipolar disorder....Pages 253-274 Quality of Life Impairment in Anxiety Disorders....Pages 275-291 Quality of Life in Obsessive-Compulsive Disorder....Pages 293-303 Front Matter....Pages 305-305 Antipsychotic Medications, Schizophrenia and the Issue of Quality of Life....Pages 307-319 Quality of life outcomes of ECT....Pages 321-331 Quality of Life in Mental Health Services....Pages 333-353 Subjective Quality of Life in Relation to Psychiatric Rehabilitation and Daily Life....Pages 355-372 Cost-Utility Analysis....Pages 373-384 Back Matter....Pages - 'This book presents new insights that health-related quality of life (HRQL) impairment is a core domain of prevalent mental disorders such as schizophrenia, schizoaffective, mood and anxiety disorders. The authors present a new conceptual framework for this field by explaining how HRQL impairment arises from interactions between various multidimensional factors. They suggest several ways in which further research could enhance our understanding of HRQL impairment, its biological basis, and its relevance to psychopathology. There is discussion of the current findings, issues and concerns regarding instruments for measuring HRQL, and quality of life impairment in specific mental disorders. Comparative data regarding HRQL deficit in these disorders and the clinical and psychosocial indicators of HRQL in each of the specific disorders are presented, and suggestions for future research are provided. This essay collection, written by leading researchers in this field presents a comprehensive framework for analyzing HRQL impairment in both theoretical and practical aspects.'--Back cover A fascinating and worthy text that presents new insights into a hugely important area of mental health. Health-related quality of life (HRQL) impairment is a core domain of prevalent mental disorders such as schizophrenia, schizoaffective, mood and anxiety disorders. The authors present a new conceptual framework for this field by explaining how HRQL impairment arises from interactions between various multidimensional factors. They suggest several ways in which further research could enhance our understanding of HRQL impairment, its biological basis, and its relevance to psychopathology.