QSAR in Environmental Toxicology : Proceedings of the Workshop on Quantitative Structure-Activity Relationships (QSAR) in Environmental Toxicology Held at McMaster University, Hamilton, Ontario, Canada, August 16–18, 1983

Ever since Rachel Carson's Silent Spring, we have generally become aware of environmental contaminants and their effects on the ecosystem. The findin~ of PCB's in fish by Soren Jensen in Sweden, the recognition of mirex as contaminant in fish from Lake Ontario, and the discoveries of contaminant laden leachates from dumpsites such as the Love Canal have become milestones in the search for and charac­ terization of contaminants in our environment. At this time, the problem no longer is so much the identifi­ cation of contaminants and their sources. Rather, we are now faced with solving questions on the fates and effects of such compounds. This includes the search for mechanisms to deal effectively with the large number of chemicals already found in water, air and biota. One of such time and cost saving scientific avenues is the field of quantitative structure-activity correlations for the prediction of the environmental behavior and effects of compounds. Front Matter....Pages i-xiv Foreword....Pages 1-2 Structure-Activity Relationships for Toxicity of Hydrocarbons, Chlorinated Hydrocarbons and Oils to Daphnia Magna ....Pages 3-16 Comparative Toxicity and Metabolism of Tetrachlorobenzene Isomers....Pages 17-37 An Examination of the Role of Rotational Barriers in the Toxicology of Pcb’s....Pages 39-66 The use of Rapid Biochemical Indicators of Toxicant Stress to Generate Biological Data Bases for QSAR....Pages 67-73 The use of Simca Pattern Recognition in the Analysis of Complex Chromatographic Data....Pages 75-88 Structure—Activity Models of Biological Oxygen Demand....Pages 89-109 Environmental Hazard Profile — Test Results as Related to Structures and Translation into the Environment....Pages 111-136 Predicting the Environmental Fate of Toxic Contaminants in Large Lakes: Data Requirements for Mathematical Models....Pages 137-151 The Need and Requirements for Quantitative Structure—Activity Relations (Qsar) in the Great Lakes Water Quality Program....Pages 153-166 Assessment of Mutagenic Effects in Amphibian Embryos....Pages 167-177 Lethal Dose Versus Lethal Concentration as Indicator of Contaminant Toxicity to Fish....Pages 179-187 Qsar Studies On Chlorophenols, Chlorobenzenes and Para-Substituted Phenols....Pages 189-206 Quantitative Structure-Activity Relationships in Ecotoxicology: Possibilities and Limits....Pages 207-222 Toxicities of Selected Chloroanilines to Four Strains of Yeast....Pages 223-233 Comparative Structure—Toxicity Relationships between Acute and Chronic Effects to Aquatic Organisms....Pages 235-260 Relationships Between Physical-Chemical and Environmental Partitioning Coefficients....Pages 261-278 Validation of Fish Toxicity QSARs for Certain Non-Reactive Non-Electrolyte Organic Compounds....Pages 279-299 The Relationship Between Bioconcentration Factor in Rainbow Trout and Physical-Chemical Properties for Some Halogenated Compounds....Pages 301-317 Toxicities of Chloroanilines to Photobacterium Phosphoreum and their Correlations with Effects on Other Organisms and Structural Parameters....Pages 319-336 Structure—Activity Correlations of Selected Azaarenes, Aromatic Amines, and Nitroaromatics....Pages 337-357 Data Evaluation in the Development of QSAR....Pages 359-368 Back Matter....Pages 369-406 Proceedings of the Workshop on Quantitative Structure - Activity Relationships (QSAR) in Environmental Toxicology held at McMaster University, Hamilton, Ontario, Canada, August 16--18, 1983